公开(公告)号：US08000438B2

公开(公告)日：2011-08-16

申请号：US11906169

申请日：2007-09-28

申请人： Edward S. Boyden ,  Roderick A. Hyde ,  Muriel Y. Ishikawa ,  Edward K. Y. Jung ,  Eric C. Leuthardt ,  Robert W. Lord ,  Nathan P. Myhrvold ,  Dennis J. Rivet ,  Michael A. Smith ,  Clarence T. Tegreene ,  Thomas A. Weaver ,  Charles Whitmer ,  Lowell L. Wood, Jr. ,  Victoria Y. H. Wood

发明人： Edward S. Boyden ,  Roderick A. Hyde ,  Muriel Y. Ishikawa ,  Edward K. Y. Jung ,  Eric C. Leuthardt ,  Robert W. Lord ,  Nathan P. Myhrvold ,  Dennis J. Rivet ,  Michael A. Smith ,  Clarence T. Tegreene ,  Thomas A. Weaver ,  Charles Whitmer ,  Lowell L. Wood, Jr. ,  Victoria Y. H. Wood

IPC分类号： G01N23/223

CPC分类号： G01N23/223 ,  G01N2223/076

摘要： Certain embodiments of one aspect relates to inducing at least one induced X-ray fluorescing photon within an at least some matter of an at least a portion of an at least one individual responsive to an at least some input energy being applied to the at least some matter of the least the portion of the at least one individual. The aspect can include X-ray fluorescence visualizing, imaging, or information providing within the at least some matter of the least the portion of the at least one individual at least partially in response to the inducing at least one induced X-ray fluorescing photon within the at least some matter of the least the portion of the at least one individual. Certain embodiments of the aspect can include providing a substantial real time tool-based operation to the at least some matter of the least the portion of the at least one individual at least partially relying on the X-ray fluorescence visualizing, imaging, or information providing within the at least some matter of the least the portion of the at least one individual.

摘要翻译： 一个方面的某些实施方案涉及在至少一些输入能量的至少一些输入能量的至少一个的至少一部分内的至少一些物质内诱导至少一个诱导的X射线荧光光子，所述至少一些输入能量被施加到所述至少一些 至少一个人的至少一部分的事物。 所述方面可以包括至少部分响应于诱导至少一个诱导的X射线荧光光子的至少一个个体的至少一部分内的至少一些物质内的X射线荧光可视化，成像或信息提供 所述至少一个个体的至少一部分的至少一部分。 该方面的某些实施例可以包括至少部分地依赖于X射线荧光可视化，成像或提供信息的至少一个个体的至少一部分的至少一些物质提供基本实时的基于工具的操作 在至少一个个体的至少一部分内的至少一些事物内。

公开(公告)号：US07742567B2

公开(公告)日：2010-06-22

申请号：US11786759

申请日：2007-04-11

申请人： Edward S. Boyden ,  Roderick A. Hyde ,  Muriel Y. Ishikawa ,  Edward K. Y. Jung ,  Eric C. Leuthardt ,  Robert W. Lord ,  Nathan P. Myhrvold ,  Dennis J. Rivet ,  Michael A. Smith ,  Clarence T. Tegreene ,  Thomas A. Weaver ,  Charles Whitmer ,  Lowell L. Wood, Jr. ,  Victoria Y. H. Wood

发明人： Edward S. Boyden ,  Roderick A. Hyde ,  Muriel Y. Ishikawa ,  Edward K. Y. Jung ,  Eric C. Leuthardt ,  Robert W. Lord ,  Nathan P. Myhrvold ,  Dennis J. Rivet ,  Michael A. Smith ,  Clarence T. Tegreene ,  Thomas A. Weaver ,  Charles Whitmer ,  Lowell L. Wood, Jr. ,  Victoria Y. H. Wood

IPC分类号： G01N23/201

CPC分类号： A61B6/483 ,  A61B6/12 ,  A61B6/145 ,  A61B6/482 ,  A61B6/505 ,  A61B6/506 ,  A61B6/507 ,  A61B6/508 ,  A61B6/548 ,  A61B18/12 ,  A61B18/20 ,  A61N7/02

摘要： One aspect relates to locating an at least one scattering event at least partially within an at least some matter of an at least a portion of an individual at least partially by directing an at least one pulse-type applied X-ray at the at least some matter of the at least the portion of the individual to create an at least one corresponding pulse-type Compton scattered X-ray, wherein the locating the at least one scattering event is based at least in part on an at least one time of flight computation derived at least in part from a combination of an at least one applied duration and an at least one scattered duration, wherein the at least one applied duration corresponds to a time for the at least one pulse-type applied X-ray to reach the at least one scattering event within the at least some matter of the at least the portion of the individual, and further wherein the at least one scattered duration corresponds to a time for the at least one corresponding pulse-type Compton scattered X-ray to thereupon travel from the at least one scattering event within the at least some matter of the at least the portion of the individual to be detected.

摘要翻译： 一个方面涉及至少部分地至少部分地至少部分地位于个体的至少一部分内的至少一个散射事件，至少部分地通过将至少一个脉冲型施加的X射线引导到至少一些 该个体的至少一部分的物质以产生至少一个对应的脉冲型康普顿散射X射线，其中定位该至少一个散射事件至少部分地基于至少一次飞行时间计算 至少部分地来自至少一个施加持续时间和至少一个散射持续时间的组合，其中所述至少一个施加的持续时间对应于所述至少一个脉冲型施加的X射线到达所述时间的时间 在所述个体的至少一部分的至少一些物质内的至少一个散射事件，并且其中所述至少一个散射持续时间对应于所述至少一个对应的脉冲型康普顿散射的时间 X射线随后从至少一个待检测个体的该部分的至少一些物质内的至少一个散射事件行进。

公开(公告)号：US07738627B2

公开(公告)日：2010-06-15

申请号：US11906156

申请日：2007-09-28

申请人： Edward S. Boyden ,  Roderick A. Hyde ,  Muriel Y. Ishikawa ,  Edward K. Y. Jung ,  Eric C. Leuthardt ,  Robert W. Lord ,  Nathan P. Myhrvold ,  Dennis J. Rivet ,  Michael A. Smith ,  Clarence T. Tegreene ,  Thomas A. Weaver ,  Charles Whitmer ,  Lowell L. Wood, Jr. ,  Victoria Y. H. Wood

发明人： Edward S. Boyden ,  Roderick A. Hyde ,  Muriel Y. Ishikawa ,  Edward K. Y. Jung ,  Eric C. Leuthardt ,  Robert W. Lord ,  Nathan P. Myhrvold ,  Dennis J. Rivet ,  Michael A. Smith ,  Clarence T. Tegreene ,  Thomas A. Weaver ,  Charles Whitmer ,  Lowell L. Wood, Jr. ,  Victoria Y. H. Wood

IPC分类号： G01N23/223

CPC分类号： G01N23/223 ,  G01N2223/076

摘要： One aspect relates to determining a location of an at least one X-ray fluorescing event occurring within an at least some matter of at least a portion of an individual, wherein the determining the location of the at least one X-ray fluorescing event is based at least in part on determining a relative angle at which an at least one applied high energy photon and/or particle is being applied to the at least some matter of the at least the portion of the individual, a relative position from which an at least one applied high energy photon and/or particle is being applied to the at least some matter of the at least the portion of the individual, a detected location of an at least one induced fluorescing X-ray photon fluoresced during the at least one X-ray fluorescing event, and a received angle at which the at least one induced fluorescing X-ray photon is received.

摘要翻译： 一个方面涉及确定发生在个体至少一部分的至少一部分内的至少一个X射线荧光事件的位置，其中确定至少一个X射线发荧光事件的位置是基于 至少部分地基于确定至少一个所施加的高能量光子和/或颗粒被施加到所述至少所述个体的所述部分中的所述至少一些物质的相对角度，相对位置至少一个 一个应用的高能量光子和/或粒子被施加到个体的至少一部分的至少一些物质，在至少一个X射线照射期间发现荧光的至少一个感应的荧光X射线光子的检测位置， 射线荧光事件和接收至少一个感应的荧光X射线光子的接收角度。

公开(公告)号：US07734012B2

公开(公告)日：2010-06-08

申请号：US11786758

申请日：2007-04-11

申请人： Edward S. Boyden ,  Roderick A. Hyde ,  Muriel Y. Ishikawa ,  Edward K. Y. Jung ,  Eric C. Leuthardt ,  Robert W. Lord ,  Nathan P. Myhrvold ,  Dennis J. Rivet ,  Michael A. Smith ,  Clarence T. Tegreene ,  Thomas A. Weaver ,  Charles Whitmer ,  Lowell L. Wood, Jr. ,  Victoria Y. H. Wood

发明人： Edward S. Boyden ,  Roderick A. Hyde ,  Muriel Y. Ishikawa ,  Edward K. Y. Jung ,  Eric C. Leuthardt ,  Robert W. Lord ,  Nathan P. Myhrvold ,  Dennis J. Rivet ,  Michael A. Smith ,  Clarence T. Tegreene ,  Thomas A. Weaver ,  Charles Whitmer ,  Lowell L. Wood, Jr. ,  Victoria Y. H. Wood

IPC分类号： G01N23/201

CPC分类号： A61B6/483 ,  A61B6/12 ,  A61B6/145 ,  A61B6/482 ,  A61B6/505 ,  A61B6/506 ,  A61B6/507 ,  A61B6/508 ,  A61B6/548 ,  A61B18/12 ,  A61B18/20 ,  A61N7/02

摘要： One aspect relates to capturing one or more tomographic-type Compton scattering based visualizations, images, or provided information of an at least some matter of at least a portion of an individual based at least partially on Compton scattering of an at least one X-ray being applied to the at least some matter of the at least the portion of the individual. Another aspect relates to deriving an at least one material characteristic distribution function that substantially fits at least some data obtained at least partially by scattering of an at least one applied X-ray within at least some matter of at least a portion of an individual to form at least one Compton scattered X-ray.

摘要翻译： 一个方面涉及至少部分地至少部分地基于至少一个X射线的康普顿散射捕获一个或多个层析摄影类型的基于康普顿散射的可视化，图像或至少部分个体的提供的信息 被应用于个人的至少一部分的至少一些事物。 另一方面涉及导出至少一种材料特征分布函数，其基本上适合于至少部分地通过在个体的至少一部分的至少一部分内的至少一部分内散射至少一个施加的X射线而获得的至少一些数据，以形成 至少有一个康普顿分散的X光片。

公开(公告)号：US08227204B2

公开(公告)日：2012-07-24

申请号：US12012209

申请日：2008-01-30

申请人： Edward S. Boyden ,  Roderick A. Hyde ,  Muriel Y. Ishikawa ,  Edward K. Y. Jung ,  Nathan P. Myhrvold ,  Clarence T. Tegreene ,  Thomas A. Weaver ,  Charles Whitmer ,  Lowell L. Wood, Jr. ,  Victoria Y. H. Wood

发明人： Edward S. Boyden ,  Roderick A. Hyde ,  Muriel Y. Ishikawa ,  Edward K. Y. Jung ,  Nathan P. Myhrvold ,  Clarence T. Tegreene ,  Thomas A. Weaver ,  Charles Whitmer ,  Lowell L. Wood, Jr. ,  Victoria Y. H. Wood

IPC分类号： C12Q1/00

CPC分类号： A61K41/0042 ,  Y10S435/968

摘要： A method, composition and system respond to ionizing radiation to adjust biological activity. In some approaches the ionizing radiation is X-ray or extreme ultraviolet radiation that produces luminescent responses that induce biologically active responses.

公开(公告)号：US07873234B2

公开(公告)日：2011-01-18

申请号：US11598214

申请日：2006-11-09

申请人： Edward S. Boyden ,  Roderick A. Hyde ,  Muriel Y. Ishikawa ,  Edward K. Y. Jung ,  Eric C. Leuthardt ,  Nathan P. Myhrvold ,  Dennis J. Rivet ,  Michael A. Smith ,  Clarence T. Tegreene ,  Thomas A. Weaver ,  Charles Whitmer ,  Lowell L. Wood, Jr. ,  Victoria Y. H. Wood

发明人： Edward S. Boyden ,  Roderick A. Hyde ,  Muriel Y. Ishikawa ,  Edward K. Y. Jung ,  Eric C. Leuthardt ,  Nathan P. Myhrvold ,  Dennis J. Rivet ,  Michael A. Smith ,  Clarence T. Tegreene ,  Thomas A. Weaver ,  Charles Whitmer ,  Lowell L. Wood, Jr. ,  Victoria Y. H. Wood

IPC分类号： G06K9/40 ,  G06K9/00

CPC分类号： G01R33/565

摘要： Certain aspects can relate to obtaining at least some input compensating information at least partially based on the distortion characterizing imaging information that when applied to an imaging modality used to obtain the at least one image information can limit distortions to the at least the portion of the at least one image information resulting from at least a portion of at least one distorting feature, wherein the at least some input compensating information is characterized based at least in part on the at least one relative orientation of the at least the portion of the at least one distorting feature relative to the at least one image information.

摘要翻译： 至少部分地基于失真表征成像信息来获得至少一些输入补偿信息的某些方面可以涉及当应用于用于获得所述至少一个图像信息的成像模态时可以限制到at的至少一部分的失真 至少一个图像信息由至少一个失真特征的至少一部分产生，其中所述至少一些输入补偿信息至少部分地基于至少一个至少一个失真特征的至少一个部分的至少一个相对取向来表征 相对于至少一个图像信息的扭曲特征。

公开(公告)号：US07773722B2

公开(公告)日：2010-08-10

申请号：US11906155

申请日：2007-09-28

申请人： Edward S. Boyden ,  Glenn B. Foster ,  Roderick A. Hyde ,  Muriel Y. Ishikawa ,  Edward K. Y. Jung ,  Eric C. Leuthardt ,  Robert W. Lord ,  Nathan P. Myhrvold ,  Dennis J. Rivet ,  Michael A. Smith ,  Clarence T. Tegreene ,  Thomas A. Weaver ,  Charles Whitmer ,  Lowell L. Wood, Jr. ,  Victoria Y. H. Wood

发明人： Edward S. Boyden ,  Glenn B. Foster ,  Roderick A. Hyde ,  Muriel Y. Ishikawa ,  Edward K. Y. Jung ,  Eric C. Leuthardt ,  Robert W. Lord ,  Nathan P. Myhrvold ,  Dennis J. Rivet ,  Michael A. Smith ,  Clarence T. Tegreene ,  Thomas A. Weaver ,  Charles Whitmer ,  Lowell L. Wood, Jr. ,  Victoria Y. H. Wood

IPC分类号： G01N23/223

CPC分类号： G01N23/223 ,  A61B5/415 ,  A61B5/418 ,  A61B5/489 ,  A61B6/12 ,  A61B6/14 ,  A61B6/4021 ,  A61B6/4291 ,  A61B6/482 ,  A61B6/485 ,  A61B6/50 ,  A61B6/501 ,  A61B6/502 ,  A61B6/503 ,  A61B6/504 ,  A61B6/505 ,  A61B6/506 ,  A61B6/507 ,  A61B6/508 ,  A61B2503/40 ,  G01N2223/076

摘要： One aspect relates to inducing at least one induced X-ray fluorescing photon at a X-ray fluorescence event within an at least some matter of an at least a portion of an at least one individual responsive to an at least some input energy being applied to the at least some matter of the at least the portion of the at least one individual. The aspect can relate to detecting the at least one induced X-ray fluorescing photon, wherein the inducing at least one induced X-ray fluorescing photon and the detecting the at least one induced X-ray fluorescing photon is configured to be performed at least partially with at least one device which is configured to be transported portably by a person.

摘要翻译： 一个方面涉及在至少一个个体的至少一部分的至少一部分内的X射线荧光事件处诱导至少一个诱导的X射线荧光光子，所述至少一个个体响应至少一些输入能量被施加到 所述至少一个个体的至少一部分的至少一些物质。 该方面可以涉及检测至少一个诱导的X射线荧光光子，其中诱导至少一个诱导的X射线荧光光子和检测至少一个诱导的X射线荧光光子被配置为至少部分地进行 其中至少一个设备被配置为可由个人便携式地传送。

公开(公告)号：US07660385B2

公开(公告)日：2010-02-09

申请号：US11906150

申请日：2007-09-28

申请人： Edward S. Boyden ,  Roderick A. Hyde ,  Muriel Y. Ishikawa ,  Edward K. Y. Jung ,  Eric C. Leuthardt ,  Robert W. Lord ,  Nathan P. Myhrvold ,  Dennis J. Rivet ,  Michael A. Smith ,  Clarence T. Tegreene ,  Thomas A. Weaver ,  Charles Whitmer ,  Lowell L. Wood, Jr. ,  Victoria Y. H. Wood

发明人： Edward S. Boyden ,  Roderick A. Hyde ,  Muriel Y. Ishikawa ,  Edward K. Y. Jung ,  Eric C. Leuthardt ,  Robert W. Lord ,  Nathan P. Myhrvold ,  Dennis J. Rivet ,  Michael A. Smith ,  Clarence T. Tegreene ,  Thomas A. Weaver ,  Charles Whitmer ,  Lowell L. Wood, Jr. ,  Victoria Y. H. Wood

IPC分类号： G01N23/223

CPC分类号： G01N23/223 ,  A61B6/00 ,  A61B6/4021 ,  A61B6/4291 ,  A61B6/485 ,  G01N2223/076 ,  G01N2223/506

摘要： One aspect can relate to determining a total time of flight that indicates an at least one applied duration and an at least one induced duration, wherein the at least one applied duration describes the time for an at least some pulse-type input energy to be applied from a transmission location to an at least one X-ray fluorescing event in the at least some matter of the at least the portion of the at least one individual, and wherein the at least one induced duration describes the time for an at least one induced X-ray fluorescing photon, to travel from the at least one X-ray fluorescing event in the at least some matter of the at least the portion of the at least one individual to a location where the at least one induced X-ray fluorescing photon is received at least partially by a detecting the at least one induced X-ray fluorescing photon. The aspect can relate to determining a location information of the at least one X-ray fluorescing event in the at least some matter of the at least the portion of the at least one individual based at least partially on the total time of flight.

摘要翻译： 一个方面可以涉及确定指示至少一个施加持续时间和至少一个诱导持续时间的总飞行时间，其中所述至少一个施加的持续时间描述了应用至少一些脉冲型输入能量的时间 在所述至少一个个体的至少一部分的至少一些物质中从透射位置到至少一个X射线荧光事件，并且其中所述至少一个诱导持续时间描述了至少一个诱导的时间 X射线荧光光子从所述至少一个个体的至少一部分中的至少一些物质中的至少一个X射线荧光事件行进到至少一个诱导的X射线荧光光子的位置 至少部分地通过检测至少一个诱导的X射线荧光光子被接收。 该方面可以涉及至少部分地基于总飞行时间来确定至少一个个体的至少一部分的至少一些事件中的至少一个X射线荧光事件的位置信息。

公开(公告)号：US07627085B2

公开(公告)日：2009-12-01

申请号：US11786744

申请日：2007-04-11

申请人： Edward S. Boyden ,  Roderick A. Hyde ,  Muriel Y. Ishikawa ,  Edward K. Y. Jung ,  Eric C. Leuthardt ,  Robert W. Lord ,  Nathan P. Myhrvold ,  Dennis J. Rivet ,  Michael A. Smith ,  Clarence T. Tegreene ,  Thomas A. Weaver ,  Charles Whitmer ,  Lowell L. Wood, Jr. ,  Victoria Y. H. Wood

发明人： Edward S. Boyden ,  Roderick A. Hyde ,  Muriel Y. Ishikawa ,  Edward K. Y. Jung ,  Eric C. Leuthardt ,  Robert W. Lord ,  Nathan P. Myhrvold ,  Dennis J. Rivet ,  Michael A. Smith ,  Clarence T. Tegreene ,  Thomas A. Weaver ,  Charles Whitmer ,  Lowell L. Wood, Jr. ,  Victoria Y. H. Wood

IPC分类号： G01N23/201

CPC分类号： A61B6/483 ,  A61B6/12 ,  A61B6/145 ,  A61B6/482 ,  A61B6/505 ,  A61B6/506 ,  A61B6/507 ,  A61B6/508 ,  A61B6/548 ,  A61B18/12 ,  A61B18/20 ,  A61N7/02

摘要： One aspect relates to at least a portion of at least one Compton scattered X-ray visualizer, imager, or information provider configured to receive an at least one Compton scattered X-ray that has scattered through a substantial scattering depth range to one or more substantial prescribed scattering depths within an at least one matter of an at least a portion of an individual based at least in part on a set of scattering characteristics, the set of scattering characteristics at least partially corresponding to the at least one matter of the least the portion of the individual; the at least the portion of the at least one Compton scattered X-ray visualizer, imager, or information provider being configured for providing an at least one Compton scattered X-ray visualization, imaging, or information providing through one or more visualization, imaging, or information providing depth ranges to one or more visualization, imaging, or information providing prescribed depths into the at least one matter of the least the portion of the individual.

摘要翻译： 一个方面涉及至少一个康普顿散射X射线可视化器，成像器或信息提供器的至少一部分，其被配置为接收已散射到大体上散射深度范围的至少一个康普顿散射X射线， 至少部分地基于一组散射特性，在至少一部分个体的至少一个物质内的规定的散射深度，所述散射特性集合至少部分地对应于至少部分的至少一个部分 的个人; 所述至少一个康普顿散射X射线可视化器，成像器或信息提供器的至少一部分被配置为提供至少一个康普顿散射X射线可视化，成像或通过一个或多个可视化成像提供的信息， 或将信息提供深度范围提供给一个或多个可视化，成像或向所述个体的至少一部分提供规定深度的信息提供给至少一个该至少一个部分。

公开(公告)号：US07724871B2

公开(公告)日：2010-05-25

申请号：US11786775

申请日：2007-04-11

申请人： Edward S. Boyden ,  Roderick A. Hyde ,  Muriel Y. Ishikawa ,  Edward K. Y. Jung ,  Eric C. Leuthardt ,  Robert W. Lord ,  Nathan P. Myhrvold ,  Dennis J. Rivet ,  Michael A. Smith ,  Clarence T. Tegreene ,  Thomas A. Weaver ,  Charles Whitmer ,  Lowell L. Wood, Jr. ,  Victoria Y. H. Wood

发明人： Edward S. Boyden ,  Roderick A. Hyde ,  Muriel Y. Ishikawa ,  Edward K. Y. Jung ,  Eric C. Leuthardt ,  Robert W. Lord ,  Nathan P. Myhrvold ,  Dennis J. Rivet ,  Michael A. Smith ,  Clarence T. Tegreene ,  Thomas A. Weaver ,  Charles Whitmer ,  Lowell L. Wood, Jr. ,  Victoria Y. H. Wood

IPC分类号： G01N23/201

CPC分类号： A61B6/483 ,  A61B6/12 ,  A61B6/145 ,  A61B6/482 ,  A61B6/505 ,  A61B6/506 ,  A61B6/507 ,  A61B6/508 ,  A61B6/548 ,  A61B18/12 ,  A61B18/20 ,  A61N7/02

摘要： A system, method, or apparatus provides information relating to at least some tissue-based matter or bone-based matter of an individual responsive to an X-ray applied to the at least some tissue-based matter or bone-based matter. In one approach, the system, method or apparatus determines information at least in part from Compton scattering principles. In one approach, the information can correspond to a range of depths or can indicate depth of features or scattering events. In one approach, the information is responsive to a determined change in direction and/or energy state of photons undergoing Compton scattering.

摘要翻译： 系统，方法或装置提供与至少一些基于组织的物质或基于骨的物质有关的信息，所述物质对应用于至少一些基于组织的物质或基于骨的物质的X射线是有反应的。 在一种方法中，系统，方法或装置至少部分地根据康普顿散射原理确定信息。 在一种方法中，信息可以对应于深度范围，或者可以指示特征或散射事件的深度。 在一种方法中，信息响应于经历康普顿散射的光子的方向和/或能量状态的确定变化。