公开(公告)号：US20160326085A1

公开(公告)日：2016-11-10

申请号：US15106194

申请日：2013-12-18

Applicant: FUDAN UNIVERSITY

Inventor： Fener CHEN ,  Qiuqin HE ,  Fangjun XIONG ,  Wenxue CHEN

IPC: C07C57/30 ,  B01J37/04 ,  C07C57/40 ,  C07C57/58 ,  C07C59/64 ,  C07C59/86 ,  C07C59/68 ,  B01J31/04 ,  C07C51/41

CPC classification number: C07C57/30 ,  B01J31/04 ,  B01J31/2239 ,  B01J37/04 ,  B01J2231/40 ,  B01J2531/004 ,  B01J2531/26 ,  C07C51/00 ,  C07C51/41 ,  C07C51/412 ,  C07C51/418 ,  C07C57/40 ,  C07C57/58 ,  C07C59/64 ,  C07C59/68 ,  C07C59/86 ,  C07C2601/08

Abstract: The present invention belongs to the technical field of chemical catalysts, and particularly relates to a zinc 2-arylpropionate catalyst, a preparation method therefor and use thereof The structural formula of the zinc 2-arylpropionate catalyst of the present invention is one of the following structures. The catalyst can be used for homogeneous catalysis of a 1,2-aryl rearrangement reaction of α-haloarylketal, and especially for synthesis of high yield and environmentally friendly 2-arylpropanonic acid non-steroidal anti-inflammatory analgesic drugs, such as, ibuprofen, ketoprofen, loxoprofen, flurbiprofen, fenoprofen, or naproxen and the like.