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    Heteroaromatic Phenylimidazole derivatives as PDE10A enzyme inhibitors
    37.
    发明申请
    Heteroaromatic Phenylimidazole derivatives as PDE10A enzyme inhibitors 有权
    杂芳基苯基咪唑衍生物作为PDE10A酶抑制剂

    公开(公告)号：US20150290191A1

    公开(公告)日：2015-10-15

    申请号：US14749754

    申请日：2015-06-25

    Applicant: H. Lundbeck A/S

    Inventor： Ask Püschl ,  Jacob Nielsen ,  Jan Kehler ,  John Paul Kilburn ,  Mauro Marigo ,  Morten Langgård

    IPC: A61K31/4985 ,  A61K45/06

    CPC classification number: A61K31/4985 ,  A61K45/06 ,  C07D471/04 ,  C07D487/04

    Abstract: This invention is directed to compounds, which are PDE10A enzyme inhibitors. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. The present invention also provides processes for the preparation of the compounds of formula I. The present invention further provides a method of treating a subject suffering from a neurodegenerative disorder comprising administering to the subject a therapeutically effective amount of a compound of formula 1. The present invention also provides a method of treating a subject suffering from a drug addiction comprising administering to the subject a therapeutically effective amount of a compound of formula I. The present invention further provides a method of treating a subject suffering from a psychiatric disorder comprising administering to the subject a therapeutically effective amount of a compound of formula 1.

    Abstract translation: 本发明涉及PDE10A酶抑制剂的化合物。 本发明提供了包含治疗有效量的本发明化合物和药学上可接受的载体的药物组合物。 本发明还提供了制备式I化合物的方法。本发明还提供了治疗患有神经退行性疾病的受试者的方法，包括向受试者施用治疗有效量的式1的化合物。本发明 本发明还提供了治疗患有药物成瘾症的受试者的方法，其包括向受试者施用治疗有效量的式I化合物。本发明还提供了治疗患有精神病障碍患者的方法，包括给予 服用治疗有效量的式1化合物。

    Quinazolin-THF-amines as PDE1 inhibitors
    38.
    发明申请
    Quinazolin-THF-amines as PDE1 inhibitors 审中-公开
    喹唑啉-THF-胺作为PDE1抑制剂

    公开(公告)号：US20150175584A1

    公开(公告)日：2015-06-25

    申请号：US14574425

    申请日：2014-12-18

    Applicant: H. LUNDBECK A/S

    Inventor： Jan Kehler ,  Lars Kyhn Rasmussen ,  Morten Langgard

    IPC: C07D405/12

    CPC classification number: C07D405/12

    Abstract: The present invention provides Quinazolin-THF-amines as PDE1 inhibitors and their use as a medicament, in particular for the treatment of neurodegenerative disorders and psychiatric disorders.

    Abstract translation: 本发明提供Quinazolin-THF-胺作为PDE1抑制剂及其作为药物的用途，特别是用于治疗神经变性疾病和精神障碍。

    (3-aryl-1H-1,2,4-triazol-5-yl)-linked heterocycle derivatives
    39.
    发明授权
    (3-aryl-1H-1,2,4-triazol-5-yl)-linked heterocycle derivatives 有权
    （3-芳基-1H-1,2,4-三唑-5-基） - 连接的杂环衍生物

    公开(公告)号：US08785653B2

    公开(公告)日：2014-07-22

    申请号：US13922371

    申请日：2013-06-20

    Applicant: H. Lundbeck A/S

    Inventor： Ask Puschl ,  Jacob Nielsen ,  Jan Kehler ,  John Paul Kilburn ,  Mauro Marigo ,  Morton Langgard

    IPC: C07D249/08 ,  C07D487/04 ,  C07D471/04

    CPC classification number: C07D487/04 ,  C07D471/04

    Abstract: This invention is directed to compounds of formula I having the structure which are PDE10A enzyme inhibitors. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. The present invention also provides processes for the preparation of the compounds of formula I. The present invention further provides a method of treating a subject suffering from a neurodegenerative disorder comprising administering to the subject a therapeutically effective amount of a compound of formula I. The present invention also provides a method of treating a subject suffering from a drug addiction comprising administering to the subject a therapeutically effective amount of a compound of formula I. The present invention further provides a method of treating a subject suffering from a psychiatric disorder comprising administering to the subject a therapeutically effective amount of a compound of formula I.

    Abstract translation: 本发明涉及具有PDE10A酶抑制剂结构的式Ⅰ化合物。 本发明提供了包含治疗有效量的本发明化合物和药学上可接受的载体的药物组合物。 本发明还提供了制备式I化合物的方法。本发明还提供了治疗患有神经变性疾病的受试者的方法，其包括向受试者施用治疗有效量的式I化合物。本发明 本发明还提供了治疗患有药物成瘾症的受试者的方法，其包括向受试者施用治疗有效量的式I化合物。本发明还提供了治疗患有精神病障碍患者的方法，包括给予 治疗有效量的式I化合物。

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