公开(公告)号：US11026923B2

公开(公告)日：2021-06-08

申请号：US17060742

申请日：2020-10-01

Applicant: H. Lundbeck A/S

Inventor： Jan Kehler ,  Karsten Juhl ,  Mauro Marigo ,  Paulo Jorge Vieira Vital ,  Mikkel Jessing ,  Morten Langgård ,  Lars Kyhn Rasmussen ,  Carl Martin Sebastian Clementson

IPC: C07D401/14 ,  C07D471/04 ,  C07D519/00 ,  A61K31/26 ,  A61K31/11 ,  A61K31/522 ,  A61K31/235 ,  A61K31/4162 ,  A61K31/4745 ,  C07D413/04 ,  C07D305/06 ,  C07D401/04

Abstract: The present invention provides 1H-pyrazolo[4,3-b]pyridin-7-amines of formula (I) as PDE1 inhibitors and their use as a medicament, in particular for the treatment of neurodegenerative disorders and psychiatric disorders.

公开(公告)号：US10912773B2

公开(公告)日：2021-02-09

申请号：US16345157

申请日：2017-10-26

Applicant: H. Lundbeck A/S

Inventor： Jan Kehler ,  Lars Kyhn Rasmussen ,  Morten Langgård ,  Mikkel Jessing ,  Paulo Jorge Vieira Vital ,  Karsten Juhl

IPC: A61K31/4985 ,  C07D487/04 ,  A61P25/28 ,  A61P25/16 ,  A61K31/5377 ,  A61K31/553 ,  A61K45/06 ,  A61K31/55

Abstract: The present invention provides combination treatments comprising compounds of Formula (I): that are PDE1 enzyme inhibitors, and other compounds useful in the treatment of neurodegenerative disorders such as for example Alzheimer's Disease, Parkinson's Disease or Huntington's Disease. Separate aspects of the invention are directed to the combined use of said compounds for the treatment of neurodegenerative and/or cognitive disorders. The present invention also provides pharmaceutical compositions comprising said PDE1 enzyme inhibitors together with other compounds useful in the treatment of neurodegenerative disorders.

公开(公告)号：US10858362B2

公开(公告)日：2020-12-08

申请号：US16002116

申请日：2018-06-07

Applicant: H. Lundbeck A/S

Inventor： Jan Kehler ,  Lars Kyhn Rasmussen ,  Morten Langgård ,  Mikkel Jessing ,  Karsten Juhl ,  Paulo Jorge Vieira Vital

IPC: C07D487/04 ,  C07D519/00

Abstract: The present invention provides imidazopyrazinones as PDE1 inhibitors and their use as a medicament, in particular for the treatment of neurodegenerative disorders and psychiatric disorders.

公开(公告)号：US10766893B2

公开(公告)日：2020-09-08

申请号：US16218019

申请日：2018-12-12

Applicant: H. Lundbeck A/S

Inventor： Karsten Juhl ,  Mikkel Jessing ,  Morten Langgård ,  Paulo Jorge Vieira Vital ,  Jan Kehler ,  Lars Kyhn Rasmussen ,  Carl Martin Sebastian Clementson ,  Mauro Marigo

IPC: C07D471/04 ,  A61P25/28 ,  A61P25/18 ,  A61P25/24 ,  A61P25/22 ,  C07D519/00

Abstract: The present invention provides 1H-pyrazolo[4,3-b]pyridines of formula (I) as PDE1 inhibitors and their use as a medicament, in particular for the treatment of neurodegenerative disorders and psychiatric disorders.

公开(公告)号：US10689379B2

公开(公告)日：2020-06-23

申请号：US16424585

申请日：2019-05-29

Applicant: H. Lundbeck A/S

Inventor： Jan Kehler ,  Lars Kyhn Rasmussen ,  Morten Langgård ,  Mikkel Jessing ,  Paulo Jorge Vieira Vital ,  Karsten Juhl ,  Mauro Marigo

IPC: A61K31/4162 ,  A61K31/4188 ,  A61K31/437 ,  A61K31/5025 ,  C07D471/04 ,  C07D487/04 ,  C07D519/00 ,  A61K31/4745 ,  A61K31/502 ,  A61K31/506 ,  A61P25/28 ,  A61P25/18 ,  A61P25/00 ,  A61P25/16

Abstract: The present invention provides compounds of formula (I) that are PDE1 enzyme inhibitors and their use as a medicament, in particular for the treatment of neurodegenerative disorders and psychiatric disorders. The present invention also provides pharmaceutical compositions comprising compounds of the invention and methods of treating disorders using the compounds of the invention.

公开(公告)号：US10351561B2

公开(公告)日：2019-07-16

申请号：US15849798

申请日：2017-12-21

Applicant: H. Lundbeck A/S

Inventor： Jan Kehler ,  Lars Kyhn Rasmussen ,  Morten Langgard ,  Mikkel Jessing ,  Paulo Jorge Vieira Vital ,  Karsten Juhl ,  Mauro Marigo

IPC: A61K31/4162 ,  A61K31/4188 ,  A61K31/437 ,  A61K31/5025 ,  C07D471/04 ,  C07D487/04 ,  A61P25/28 ,  A61P25/18 ,  A61P25/00 ,  A61P25/16 ,  C07D519/00

Abstract: The present invention provides compounds of formula (I) that are PDE1 enzyme inhibitors and their use as a medicament, in particular for the treatment of neurodegenerative disorders and psychiatric disorders. The present invention also provides pharmaceutical compositions comprising compounds of the invention and methods of treating disorders using the compounds of the invention.

公开(公告)号：US10150771B2

公开(公告)日：2018-12-11

申请号：US15517348

申请日：2015-10-09

Applicant: H. Lundbeck A/S

Inventor： Jan Kehler ,  Lars Kyhn Rasmussen ,  Mikkel Jessing

IPC: C07D487/04

Abstract: The present invention provides triazolopyrazinones as PDE1 inhibitors and their use as a medicament, in particular for the treatment of neurodegenerative disorders and psychiatric disorders.

公开(公告)号：US20170298072A1

公开(公告)日：2017-10-19

申请号：US15517348

申请日：2015-10-09

Applicant: H. Lundbeck A/S

Inventor： Jan Kehler ,  Lars Kyhn Rasmussen ,  Mikkel Jessing

IPC: C07D487/04

CPC classification number: C07D487/04

Abstract: The present invention provides triazolopyrazinones as PDE1 inhibitors and their use as a medicament, in particular for the treatment of neurodegenerative disorders and psychiatric disorders.

公开(公告)号：US20170291903A1

公开(公告)日：2017-10-12

申请号：US15615380

申请日：2017-06-06

Applicant: H. Lundbeck A/S

Inventor： Jan Kehler ,  Lars Kyhn Rasmussen ,  Morten Langgård ,  Mikkel Jessing ,  Paulo Jorge Vieira Vital ,  Karsten Juhl

IPC: C07D487/04 ,  C07D519/00

CPC classification number: C07D487/04 ,  C07D519/00

Abstract: The present invention provides imidazopyrazinones as PDE1 inhibitors and their use as a medicament, in particular for the treatment of neurodegenerative disorders and psychiatric disorders.

公开(公告)号：US09593105B2

公开(公告)日：2017-03-14

申请号：US15205850

申请日：2016-07-08

Applicant: H. Lundbeck A/S

Inventor： John Paul Kilburn ,  Lars Kyhn Rasmussen ,  Mikkel Jessing ,  Eman Mohamed Eldemenky ,  Bin Chen ,  Yu Jiang

IPC: C07D413/06 ,  C07D403/06 ,  C07D401/06 ,  C07D295/13 ,  C07D267/10 ,  C07D213/40 ,  C07D211/38 ,  C07D209/52

CPC classification number: A61K31/553 ,  A61K31/40 ,  A61K31/445 ,  A61K31/4453 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/506 ,  A61K31/5375 ,  A61K31/5377 ,  A61K31/625 ,  C07D209/52 ,  C07D211/38 ,  C07D213/40 ,  C07D239/26 ,  C07D267/10 ,  C07D295/13 ,  C07D401/06 ,  C07D403/06 ,  C07D413/06

Abstract: The present invention is directed to novel cyclic amines which inhibit the P2X7 receptor.

Abstract translation: 本发明涉及抑制P2X7受体的新型环胺。