公开(公告)号：US20160199435A1

公开(公告)日：2016-07-14

申请号：US14832403

申请日：2015-08-21

申请人： Hazel H. Szeto

发明人： Hazel H. Szeto

IPC分类号： A61K38/07

CPC分类号： A61K38/07 ,  A61K38/06

摘要： The invention provides methods of preventing or treating metabolic syndrome in a mammalian subject. The methods comprise administering to the subject an effective amount of an aromatic-cationic peptide to subjects in need thereof.

摘要翻译： 本发明提供了预防或治疗哺乳动物受试者中代谢综合征的方法。 所述方法包括向有需要的受试者施用有效量的芳族阳离子肽。

公开(公告)号：US08592373B2

公开(公告)日：2013-11-26

申请号：US13402620

申请日：2012-02-22

申请人： Hazel H. Szeto ,  Diane Felsen

发明人： Hazel H. Szeto ,  Diane Felsen

IPC分类号： A61K38/00 ,  A61K38/06 ,  A61K38/07 ,  A61P13/12

CPC分类号： A61K38/07 ,  A61K38/00 ,  A61K38/06 ,  C07K5/1016 ,  C07K5/1019

摘要： The disclosure relates to a method for protecting a kidney from renal injury. For example, acute renal injury may be associated with decreased or blocked blood flow in the subject's kidney or exposure to a nephrotoxic agent, such as a radiocontrast dye. The methods include administering to the subject an effective amount of an aromatic-cationic peptide to a subject in need thereof.

公开(公告)号：US20120149638A1

公开(公告)日：2012-06-14

申请号：US13310269

申请日：2011-12-02

申请人： P. Darrell Neufer ,  Ethan J. Anderson ,  Hazel H. Szeto

发明人： P. Darrell Neufer ,  Ethan J. Anderson ,  Hazel H. Szeto

IPC分类号： A61K38/17 ,  A61P5/50

CPC分类号： A61K38/07 ,  A61K38/06 ,  C07K5/1019

摘要： The invention provides methods of preventing or treating insulin resistance in a mammalian subject. The methods comprise administering to the subject an effective amount of an aromatic-cationic peptide having at least one net positive charge; a minimum of four amino acids; a maximum of about twenty amino acids; a relationship between the minimum number of net positive charges (pm) and the total number of amino acid residues (r) wherein 3pm is the largest number that is less than or equal to r+1; and a relationship between the minimum number of aromatic groups (a) and the total number of net positive charges (pt) wherein 2a is the largest number that is less than or equal to pt+1, except that when a is 1, pt may also be 1.

摘要翻译： 本发明提供在哺乳动物受试者中预防或治疗胰岛素抵抗的方法。 所述方法包括向受试者施用有效量的具有至少一个净正电荷的芳族 - 阳离子肽; 至少四个氨基酸; 最多约20个氨基酸; 净正电荷（pm）的最小数量与氨基酸残基总数（r）之间的关系，其中3pm是小于或等于r + 1的最大数; 以及芳族基团（a）的最小数目和净正电荷总数（pt）之间的关系，其中2a是小于或等于pt + 1的最大数目，除了当a为1时，pt可以 也是1。

公开(公告)号：US08143219B2

公开(公告)日：2012-03-27

申请号：US12392565

申请日：2009-02-25

申请人： Hazel H. Szeto ,  Diane Felsen

发明人： Hazel H. Szeto ,  Diane Felsen

IPC分类号： A61K38/00 ,  A61K38/07 ,  A61P13/12

CPC分类号： A61K38/07 ,  A61K38/00 ,  A61K38/06 ,  C07K5/1016 ,  C07K5/1019

摘要： The disclosure relates to a method for protecting a kidney from renal injury. For example, acute renal injury may be associated with decreased or blocked blood flow in the subject's kidney or exposure to a nephrotoxic agent, such as a radiocontrast dye. The methods include administering to the subject an effective amount of an aromatic-cationic peptide to a subject in need thereof.

摘要翻译： 本公开涉及一种保护肾脏免受肾损伤的方法。 例如，急性肾损伤可能与受试者的肾脏中的血液流动减少或阻塞相关，或者与肾毒性试剂例如放射性对比染料相接触。 所述方法包括向受试者施用有效量的芳族阳离子肽至有需要的受试者。

公开(公告)号：US20110039766A1

公开(公告)日：2011-02-17

申请号：US12854551

申请日：2010-08-11

申请人： Hazel H. Szeto

发明人： Hazel H. Szeto

IPC分类号： A61K38/07 ,  A61P3/10 ,  A61P3/04 ,  A61P3/06 ,  A61P9/12 ,  A61P3/00

CPC分类号： A61K38/07 ,  A61K38/06

摘要： The invention provides methods of preventing or treating metabolic syndrome in a mammalian subject. The methods comprise administering to the subject an effective amount of an aromatic-cationic peptide to subjects in need thereof.

摘要翻译： 本发明提供了预防或治疗哺乳动物受试者中代谢综合征的方法。 所述方法包括向有需要的受试者施用有效量的芳族阳离子肽。

公开(公告)号：US20100311664A1

公开(公告)日：2010-12-09

申请号：US12843333

申请日：2010-07-26

申请人： Hazel H. Szeto

发明人： Hazel H. Szeto

IPC分类号： A61K38/08 ,  A61P25/16

CPC分类号： A61K38/07 ,  A61K38/08 ,  A61K38/10 ,  C07K5/1019

摘要： The invention provides a method for reducing oxidative damage in a mammal, a removed organ, or a cell in need thereof. The method comprises administering an effective amount of an aromatic cationic peptide. The aromatic cationic peptide has (a) at least one net positive charge; (b) a minimum of three amino acids; (c) a maximum of about twenty amino acids, (d) a relationship between the minimum number of net positive charges (pm) and the total number of amino acid residues (r) wherein 3 pm is the largest number that is less than or equal to r+1; (e) a relationship between the minimum number of aromatic groups (a) and the total number of net positive charges (pt) wherein 3a or 2a is the largest number that is less than or equal to pt+1, except that when a is 1, pt may also be 1; and (f) at least one tyrosine or tryptophan amino acid.

摘要翻译： 本发明提供了一种减少哺乳动物，被去除的器官或有需要的细胞的氧化损伤的方法。 该方法包括施用有效量的芳族阳离子肽。 芳族阳离子肽具有（a）至少一个净正电荷; （b）至少三个氨基酸; （c）最多约20个氨基酸，（d）最小净正电荷数（pm）与氨基酸残基总数（r）之间的关系，其中3pm是最小数目小于或等于 等于r + 1; （e）芳族基团（a）的最小数目和净正电荷总数（pt）之间的关系，其中3a或2a是小于或等于pt + 1的最大数，除了当a为 1，pt也可以为1; 和（f）至少一种酪氨酸或色氨酸氨基酸。

公开(公告)号：US20090221514A1

公开(公告)日：2009-09-03

申请号：US12392565

申请日：2009-02-25

申请人： Hazel H. Szeto ,  Diane Felsen

发明人： Hazel H. Szeto ,  Diane Felsen

IPC分类号： A61K38/07 ,  A61K38/06

CPC分类号： A61K38/07 ,  A61K38/00 ,  A61K38/06 ,  C07K5/1016 ,  C07K5/1019

摘要： The disclosure relates to a method for protecting a kidney from renal injury. For example, acute renal injury may be associated with decreased or blocked blood flow in the subject's kidney or exposure to a nephrotoxic agent, such as a radiocontrast dye. The methods include administering to the subject an effective amount of an aromatic-cationic peptide to a subject in need thereof.

摘要翻译： 本公开涉及一种保护肾脏免受肾损伤的方法。 例如，急性肾损伤可能与受试者的肾脏中的血液流动减少或阻塞相关，或者与肾毒性试剂例如放射性对比染料相接触。 所述方法包括向受试者施用有效量的芳族阳离子肽至有需要的受试者。

公开(公告)号：US20170143784A1

公开(公告)日：2017-05-25

申请号：US15196864

申请日：2016-06-29

申请人： Hazel H. Szeto ,  Scott Kline Powers

发明人： Hazel H. Szeto ,  Scott Kline Powers

IPC分类号： A61K38/06

CPC分类号： A61K38/06 ,  A61P21/00 ,  A61P39/06

摘要： The present disclosure provides methods and compositions for preventing or treating MV-induced or disuse-induced skeletal muscle infirmities in a mammalian subject. The methods further include administering to the subject an effective amount of an aromatic-cationic peptide.

公开(公告)号：US20150359839A1

公开(公告)日：2015-12-17

申请号：US14598095

申请日：2015-01-15

申请人： P. Darrell Neufer ,  Ethan J. Anderson ,  Hazel H. Szeto

发明人： P. Darrell Neufer ,  Ethan J. Anderson ,  Hazel H. Szeto

IPC分类号： A61K38/07

CPC分类号： A61K38/07 ,  A61K38/06 ,  C07K5/1019

摘要： The invention provides methods of preventing or treating insulin resistance in a mammalian subject. The methods comprise administering to the subject an effective amount of an aromatic-cationic peptide having at least one net positive charge; a minimum of four amino acids; a maximum of about twenty amino acids; a relationship between the minimum number of net positive charges (pm) and the total number of amino acid residues (r) wherein 3pm is the largest number that is less than or equal to r+1; and a relationship between the minimum number of aromatic groups (a) and the total number of net positive charges (pt) wherein 2a is the largest number that is less than or equal to pt+1, except that when a is 1, pt may also be 1.

公开(公告)号：US20130017150A1

公开(公告)日：2013-01-17

申请号：US13402620

申请日：2012-02-22

申请人： Hazel H. Szeto ,  Diane Felsen

发明人： Hazel H. Szeto ,  Diane Felsen

IPC分类号： A61K38/07 ,  A61P13/12 ,  A61K51/04

CPC分类号： A61K38/07 ,  A61K38/00 ,  A61K38/06 ,  C07K5/1016 ,  C07K5/1019

摘要： The disclosure relates to a method for protecting a kidney from renal injury. For example, acute renal injury may be associated with decreased or blocked blood flow in the subject's kidney or exposure to a nephrotoxic agent, such as a radiocontrast dye. The methods include administering to the subject an effective amount of an aromatic-cationic peptide to a subject in need thereof.