公开(公告)号：US09968931B2

公开(公告)日：2018-05-15

申请号：US12288159

申请日：2008-10-15

申请人： Nan Zhang ,  Zhiliang Wan

发明人： Nan Zhang ,  Zhiliang Wan

IPC分类号： B01D33/00 ,  B01D35/00 ,  B01L3/00

CPC分类号： B01L3/502753 ,  B01L2300/0681 ,  B01L2400/0406

摘要： This invention provides lateral flow filters with pore size gradients and with features to prevent peripheral flows around the filter. The filters can be laminated composites of two or more planar filter layers. Cartridges employing the filters can include a filtration chamber configured to retain the lateral flow filters including a port for sample application and a capillary channel for filtrate egress. The fluid egress port can be positioned to receive filtrate from one filter layer but not another.

公开(公告)号：US09121893B2

公开(公告)日：2015-09-01

申请号：US11532665

申请日：2006-09-18

申请人： Matthias J. Schmand ,  Ron Grazioso ,  Ronald Nutt ,  Robert E. Nutt ,  Nan Zhang ,  James Luke Corbeil ,  Ralf Ladebeck ,  Markus Vester ,  Günter Schnur ,  Wolfgang Renz ,  Hubertus Fischer ,  Bernd J. Pichler

发明人： Matthias J. Schmand ,  Ron Grazioso ,  Ronald Nutt ,  Robert E. Nutt ,  Nan Zhang ,  James Luke Corbeil ,  Ralf Ladebeck ,  Markus Vester ,  Günter Schnur ,  Wolfgang Renz ,  Hubertus Fischer ,  Bernd J. Pichler

IPC分类号： G01T1/164 ,  G01T1/166 ,  G01R33/28 ,  G01R33/26 ,  G01R33/381 ,  G01R33/48 ,  G01T1/16 ,  G01T1/29 ,  A61B6/03 ,  A61B8/08

CPC分类号： G01R33/481 ,  A61B6/037 ,  A61B8/5261 ,  G01R33/26 ,  G01R33/28 ,  G01R33/307 ,  G01R33/381 ,  G01T1/1603 ,  G01T1/2018 ,  G01T1/2985

摘要： APD-based PET modules are provided for use in combined PET/MR imaging. Each module includes a number of independent, optically isolated detectors. Each detector includes an array of scintillator (e.g. LSO) crystals read out by an array of APDs. The modules are positioned in the tunnel of a MR scanner. Simultaneous, artifact-free images can be acquired with the APD-based PET and MR system resulting in a high-resolution and cost-effective integrated PET/MR system.

摘要翻译： 提供基于APD的PET模块，用于组合PET / MR成像。 每个模块包括多个独立的光隔离探测器。 每个检测器包括由APD阵列读出的闪烁体阵列（例如LSO）晶体。 模块位于MR扫描仪的通道中。 基于APD的PET和MR系统可以获得同时，无伪影的图像，从而产生高分辨率和成本效益的集成PET / MR系统。

公开(公告)号：US08791514B2

公开(公告)日：2014-07-29

申请号：US13540079

申请日：2012-07-02

申请人： Debora Henseler ,  Ronald Grazioso ,  Nan Zhang

发明人： Debora Henseler ,  Ronald Grazioso ,  Nan Zhang

IPC分类号： H01L27/146 ,  G01T1/24

CPC分类号： G01T1/248 ,  H01L27/14658

摘要： An apparatus and method to decrease light saturation in a photosensor array and increase detection efficiency uses a light distribution profile from a scintillator-photodetector geometry to configure the photosensor array to have a non-uniform sensor cell pattern, with varying cell density and/or varying cell size and shape. A solid-state photosensor such as a SiPM sensor having such a non-uniform cell structure realizes improved energy resolution, higher efficiency and increased signal linearity. In addition the non-uniform sensor cell array can have improved timing resolution due to improvements in statistical fluctuations. A particular embodiment for such photosensors is in PET medical imaging.

摘要翻译： 降低光传感器阵列中的光饱和度并提高检测效率的装置和方法使用来自闪烁体 - 光电检测器几何形状的光分布分布来配置光传感器阵列具有不均匀的传感器单元图案，具有变化的单元密度和/或变化 细胞大小和形状。 诸如具有这种非均匀单元结构的SiPM传感器的固态光电传感器实现了改进的能量分辨率，更高的效率和更高的信号线性度。 此外，由于统计波动的改善，非均匀传感器单元阵列可以改善时序分辨率。 这种感光器的特定实施例是在PET医学成像中。

公开(公告)号：US20130116265A1

公开(公告)日：2013-05-09

申请号：US13512524

申请日：2010-07-30

申请人： Nan Zhang ,  Rong Zhong

发明人： Nan Zhang ,  Rong Zhong

IPC分类号： C07D487/04

CPC分类号： C07D487/04 ,  A61K31/519 ,  C07C59/265

摘要： The present invention discloses a compound of formula (I) and citrate thereof as type 5 phosphodiesterase inhibitor, a preparation method thereof, and a pharmaceutical composition including the compound of formula (I) and citrate thereof. The experimental results of the present invention prove that the compound of formula (I) and citrate thereof can inhibit activity of type 5 phosphodiesterase, and can be used for treating erectile dysfunction, inhibiting platelet aggregation and treating thrombosis, decreasing pulmonary hypertension and treating cardiovascular diseases, treating asthma and treating diabetes gastroparesis.

摘要翻译： 本发明公开了式（I）化合物及其柠檬酸盐作为5型磷酸二酯酶抑制剂及其制备方法，以及含有式（I）化合物及其柠檬酸盐的药物组合物。 本发明的实验结果证明，式（I）化合物及其柠檬酸盐可抑制5型磷酸二酯酶的活性，可用于治疗勃起功能障碍，抑制血小板聚集和治疗血栓形成，降低肺动脉高压和治疗心血管疾病 治疗哮喘和治疗糖尿病胃轻瘫。

公开(公告)号：US20130009063A1

公开(公告)日：2013-01-10

申请号：US13539915

申请日：2012-07-02

申请人： Debora Henseler ,  Ronald Grazioso ,  Nan Zhang ,  Matthias J. Schmand ,  Sanghee Cho

发明人： Debora Henseler ,  Ronald Grazioso ,  Nan Zhang ,  Matthias J. Schmand ,  Sanghee Cho

IPC分类号： G01T1/164

CPC分类号： G01T1/2985 ,  A61B6/00 ,  A61B6/037 ,  G01T1/00

摘要： A system and method are provided for determining the onset of gamma interactions for positron emission tomography (PET) imaging more accurately than with existing techniques. The timing of a sequence of primary trigger events is obtained and used to determine a weighted combination, which mixes the timing information from the various primary trigger events to compute an overall event trigger timing with improved time resolution. Numerical simulations demonstrate that the invention improves time resolution by approximately 10% over state-of-the-art methods. This improved time resolution directly benefits the imaging performance of the PET scanner, especially in time-of-flight (TOF) mode, where a high time resolution directly translates to a reduction in image noise at the same dose—or, alternatively, a reduction of dose to the patient or scan time for the same image quality.

摘要翻译： 提供了一种系统和方法，用于比现有技术更准确地确定正电子发射断层摄影（PET）成像的γ相互作用的发生。 获得主要触发事件序列的定时并用于确定加权组合，其混合来自各种主要触发事件的定时信息以通过改进的时间分辨率计算总体事件触发时序。 数值模拟表明，本发明使用最先进的方法将时间分辨率提高约10％。 这种改进的时间分辨率直接有利于PET扫描仪的成像性能，特别是在飞行时间（TOF）模式下，其中高时间分辨率直接转换为以相同剂量降低图像噪声，或者替代地，减少 给予患者剂量或扫描时间相同的图像质量。

公开(公告)号：US20120294904A1

公开(公告)日：2012-11-22

申请号：US13474749

申请日：2012-05-18

申请人： Rebecca A. Bader ,  Nan Zhang

发明人： Rebecca A. Bader ,  Nan Zhang

IPC分类号： A61K31/726 ,  A61K9/00 ,  B82Y15/00

CPC分类号： A61K9/5161 ,  A61K31/519 ,  B82Y30/00

摘要： Gel nanoparticles for encapsulating and delivering a pharmaceutical compound to a patient. The nanoparticles are formed from N-trimethyl chitosan and polysialic acid, preferably in the presence of sodium tripolyphosphate. A ratio of polysialic acid to N-trimethyl chitosan of about 0.5 to 1 produces nanoparticles having diameter of about 100 nm (plus or minus 25 nm) and a zero potential above 30 milivolts that can stability contain a pharmaceutical compound, such as methotrexate, for delivery to a patient.

摘要翻译： 用于将药物化合物包封并递送至患者的凝胶纳米颗粒。 纳米颗粒由N-三甲基壳聚糖和聚唾液酸形成，优选在三聚磷酸钠存在下形成。 聚唾液酸与N-三甲基壳聚糖的比例为约0.5:1，产生直径约100nm（正或负25nm）和零电位高于30毫升的纳米颗粒，其稳定性含有药物化合物，例如甲氨蝶呤，用于 送到病人身上

公开(公告)号：USRE42376E1

公开(公告)日：2011-05-17

申请号：US12785269

申请日：2010-05-21

申请人： Allan Wissner ,  Hwei-Ru Tsou ,  Dan M. Berger ,  Middleton B. Floyd, Jr. ,  Philip R. Hamann ,  Nan Zhang ,  Philip Frost

发明人： Allan Wissner ,  Hwei-Ru Tsou ,  Dan M. Berger ,  Middleton B. Floyd, Jr. ,  Philip R. Hamann ,  Nan Zhang ,  Philip Frost

IPC分类号： A61K31/47 ,  C07D215/44

CPC分类号： C07D215/54 ,  C07D215/44 ,  C07D215/56

摘要： This invention provides compounds of formula I having the structure wherein G1, G2, R1, R4, Z, n, and X are defined in the specification or a pharmaceutically acceptable salt thereof which are useful as antineoplastic agents and in the treatment of polycystic kidney disease.

摘要翻译： 本发明提供具有以下结构的式I化合物：其中G1，G2，R1，R4，Z，n和X在本说明书中定义，或其药学上可接受的盐，其可用作抗肿瘤剂和治疗多囊肾病 。

公开(公告)号：US07924079B2

公开(公告)日：2011-04-12

申请号：US12558007

申请日：2009-09-11

申请人： Matthias J. Schmand ,  Nan Zhang

发明人： Matthias J. Schmand ,  Nan Zhang

IPC分类号： H03L5/00

CPC分类号： G01T1/248

摘要： A simple, low cost circuit with only passive components, and thus low power consumption, is provided for baseline restoration of an AC coupled signal. The circuit includes a passive network of diodes arranged in a star configuration and an RF-transformer. A differential signal strategy may be employed by including a differential amplifier at the input and output of the passive network.

摘要翻译： 提供了一种简单的低成本电路，仅具有无源组件，因此具有低功耗，用于AC耦合信号的基线恢复。 该电路包括以星形结构布置的二极管的无源网络和RF变压器。 可以通过在无源网络的输入和输出处包括差分放大器来采用差分信号策略。

公开(公告)号：US20100074396A1

公开(公告)日：2010-03-25

申请号：US12498101

申请日：2009-07-06

申请人： Matthias J. Schmand ,  Debora Henseler ,  Ronald Grazioso ,  Nan Zhang ,  Mark S. Andreaco

发明人： Matthias J. Schmand ,  Debora Henseler ,  Ronald Grazioso ,  Nan Zhang ,  Mark S. Andreaco

IPC分类号： A61B6/03 ,  G01T1/24 ,  G01T1/20

CPC分类号： G01T1/1644 ,  A61B6/032 ,  A61B6/037

摘要： Medical imaging may be accomplished with a high photoconductive gain at a relatively low operating voltage by employing a black silicon photodetector and integrating CMOS components with elements of the photodetector.

摘要翻译： 通过采用黑硅光电检测器并将CMOS部件与光电检测器的元件集成，可以在相对低的工作电压下以高的光电导增益实现医学成像。

公开(公告)号：US20090108206A1

公开(公告)日：2009-04-30

申请号：US12260966

申请日：2008-10-29

申请人： Johannes Breuer ,  Ronald Grazioso ,  James Corbeil ,  Nan Zhang ,  Matthias J. Schmand

发明人： Johannes Breuer ,  Ronald Grazioso ,  James Corbeil ,  Nan Zhang ,  Matthias J. Schmand

IPC分类号： G01T1/164 ,  G01V3/00

CPC分类号： G01R33/28 ,  A61B5/150992 ,  G01R33/481 ,  G01T1/1603

摘要： An automated blood sampling system for PET imaging applications that can be operated in or very near to the field of view (FOV) of an MR scanner, such as in a combined MR/PET imaging system. A radiation detector uses APDs (avalanche photo-diodes) to collect scintillation light from crystals in which the positron-electron annihilation photons are absorbed. The necessary gamma shielding is made from a suitable shielding material, preferably tungsten polymer composite. Because the APDs are quite small and are magnetically insensitive, they can be operated in the strong magnetic field of an MR apparatus without disturbance.

摘要翻译： 用于PET成像应用的自动采血系统，其可以在MR扫描器的视野（FOV）中或非常接近的范围内操作，例如在组合的MR / PET成像系统中。 辐射检测器使用APD（雪崩光电二极管）从正电子 - 电子湮灭光子被吸收的晶体中收集闪烁光。 必要的伽马屏蔽由合适的屏蔽材料制成，优选钨聚合物复合材料。 由于APD相当小并且磁性不敏感，所以它们可以在无扰动的MR设备的强磁场中操作。