公开(公告)号：US20080025989A1

公开(公告)日：2008-01-31

申请号：US11735376

申请日：2007-04-13

申请人： Che-Leung Law ,  Julie McEarchern ,  Jonathan Drachman

发明人： Che-Leung Law ,  Julie McEarchern ,  Jonathan Drachman

IPC分类号： A61K39/395

CPC分类号： C07K16/2875 ,  A61K47/65 ,  A61K47/6803 ,  A61K47/6849 ,  A61K49/0008 ,  A61K49/0041 ,  A61K49/0058 ,  A61K2039/505 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/73

摘要： Disclosed are anti-CD70 antibodies and derivatives thereof conjugated to cytotoxic, immunosuppressive, or other therapeutic agents, as well as pharmaceutical compositions and kits comprising the antibody- and antibody derivative-drug conjugates. Also disclosed are methods, for the treatment of CD70-expressing cancers and immunological disorders, comprising administering to a subject the disclosed pharmaceutical compositions.

摘要翻译： 公开了与细胞毒性，免疫抑制或其它治疗剂缀合的抗CD70抗体及其衍生物，以及包含抗体 - 和抗体衍生物 - 药物共轭物的药物组合物和试剂盒。 还公开了用于治疗表达CD70的癌症和免疫学疾病的方法，包括向受试者施用所公开的药物组合物。

公开(公告)号：US20060083736A1

公开(公告)日：2006-04-20

申请号：US11251173

申请日：2005-10-14

申请人： Che-Leung Law ,  Julie McEarchern ,  Alan Wahl

发明人： Che-Leung Law ,  Julie McEarchern ,  Alan Wahl

IPC分类号： A61K39/395

CPC分类号： C07K16/2875 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/732 ,  C07K2317/734

摘要： Disclosed are CD70 binding agents, such as anti-CD70 antibodies and derivatives, that induce a cytotoxic, cytostatic or immunosuppressive without conjugation to a therapeutic agents, as well as pharmaceutical compositions and kits comprising the antibody or derivative. Also disclosed are methods for the treatment and prevention of CD70-expressing cancers and immunological disorders comprising administering to a subject the CD70-binding agent.