公开(公告)号：US20090076276A1

公开(公告)日：2009-03-19

申请号：US12263963

申请日：2008-11-03

申请人： Masakazu FUJIO ,  Hiroyuki SATOH ,  Shinya INOUE ,  Toshifumi MATSUMOTO ,  Yasuhiro EGI

发明人： Masakazu FUJIO ,  Hiroyuki SATOH ,  Shinya INOUE ,  Toshifumi MATSUMOTO ,  Yasuhiro EGI

IPC分类号： C07D403/02 ,  C07D311/02

CPC分类号： C07D401/04 ,  A61K31/4725 ,  C07D207/12 ,  C07D401/06 ,  C07D405/06

摘要： The present invention relates to an isoquinoline compound represented by the following formula (I), an optically active form thereof, a pharmaceutically acceptable salt thereof, a water adduct thereof, a hydrate thereof and a solvate thereof, as well as an agent for the prophylaxis and/or treatment of a disease caused by hyperreactivity of poly(ADP-ribose)polymerase, containing the compound, and a poly(ADP-ribose)polymerase inhibitor containing the compound. In addition, this compound is useful as an agent for the prophylaxis and/or treatment of cerebral infarction, particularly as an agent for the prophylaxis and/or treatment of acute cerebral infarction. Furthermore, this compound is useful as a prophylactic and/or therapeutic agent that improves neurological symptoms associated with cerebral infarction, particularly acute cerebral infarction. wherein the symbols are the same as defined in the description.

摘要翻译： 本发明涉及由下式（I）表示的异喹啉化合物，其光学活性形式，其药学上可接受的盐，其水加合物，其水合物和溶剂化物，以及预防药物 和/或治疗由含有该化合物的聚（ADP-核糖）聚合酶和含该化合物的聚（ADP-核糖）聚合酶抑制剂）的高反应性引起的疾病。 此外，该化合物可用作预防和/或治疗脑梗塞的药剂，特别是作为预防和/或治疗急性脑梗死的药物。 此外，该化合物可用作改善与脑梗死特别是急性脑梗死相关的神经症状的预防和/或治疗剂。 其中符号与描述中定义的相同。