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公开(公告)号：US20090076276A1
公开(公告)日：2009-03-19
申请号：US12263963
申请日：2008-11-03
IPC分类号： C07D403/02 , C07D311/02
CPC分类号： C07D401/04 , A61K31/4725 , C07D207/12 , C07D401/06 , C07D405/06
摘要： The present invention relates to an isoquinoline compound represented by the following formula (I), an optically active form thereof, a pharmaceutically acceptable salt thereof, a water adduct thereof, a hydrate thereof and a solvate thereof, as well as an agent for the prophylaxis and/or treatment of a disease caused by hyperreactivity of poly(ADP-ribose)polymerase, containing the compound, and a poly(ADP-ribose)polymerase inhibitor containing the compound. In addition, this compound is useful as an agent for the prophylaxis and/or treatment of cerebral infarction, particularly as an agent for the prophylaxis and/or treatment of acute cerebral infarction. Furthermore, this compound is useful as a prophylactic and/or therapeutic agent that improves neurological symptoms associated with cerebral infarction, particularly acute cerebral infarction. wherein the symbols are the same as defined in the description.
摘要翻译： 本发明涉及由下式（I）表示的异喹啉化合物，其光学活性形式，其药学上可接受的盐，其水加合物，其水合物和溶剂化物，以及预防药物 和/或治疗由含有该化合物的聚（ADP-核糖）聚合酶和含该化合物的聚（ADP-核糖）聚合酶抑制剂）的高反应性引起的疾病。 此外，该化合物可用作预防和/或治疗脑梗塞的药剂，特别是作为预防和/或治疗急性脑梗死的药物。 此外，该化合物可用作改善与脑梗死特别是急性脑梗死相关的神经症状的预防和/或治疗剂。 其中符号与描述中定义的相同。
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公开(公告)号：US20070161620A1
公开(公告)日：2007-07-12
申请号：US11688103
申请日：2007-03-19
IPC分类号： A61K31/55 , A61K31/496 , A61K31/4709 , C07D401/02 , C07D403/02
CPC分类号： C07D401/04 , A61K31/4725 , C07D207/12 , C07D401/06 , C07D405/06
摘要： The present invention relates to an isoquinoline compound represented by the following formula (I), an optically active form thereof, a pharmaceutically acceptable salt thereof, a water adduct thereof, a hydrate thereof and a solvate thereof, as well as an agent for the prophylaxis and/or treatment of a disease caused by hyperreactivity of poly(ADP-ribose)polymerase, containing the compound, and a poly(ADP-ribose)polymerase inhibitor containing the compound. In addition, this compound is useful as an agent for the prophylaxis and/or treatment of cerebral infarction, particularly as an agent for the prophylaxis and/or treatment of acute cerebral infarction. Furthermore, this compound is useful as a prophylactic and/or therapeutic agent that improves neurological symptoms associated with cerebral infarction, particularly acute cerebral infarction. wherein the symbols are the same as defined in the description.
摘要翻译： 本发明涉及由下式（I）表示的异喹啉化合物，其光学活性形式，其药学上可接受的盐，其水加合物，其水合物和溶剂化物，以及预防药物 和/或治疗由含有该化合物的聚（ADP-核糖）聚合酶和含该化合物的聚（ADP-核糖）聚合酶抑制剂）的高反应性引起的疾病。 此外，该化合物可用作预防和/或治疗脑梗塞的药剂，特别是作为预防和/或治疗急性脑梗死的药物。 此外，该化合物可用作改善与脑梗死特别是急性脑梗死相关的神经症状的预防和/或治疗剂。 其中符号与描述中定义的相同。
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公开(公告)号：US07220759B2
公开(公告)日：2007-05-22
申请号：US10836377
申请日：2004-04-30
IPC分类号： C07D217/22 , A61K31/47
CPC分类号： C07D401/04 , A61K31/4725 , C07D207/12 , C07D401/06 , C07D405/06
摘要： The present invention relates to an isoquinoline compound represented by the following formula (I), an optically active form thereof, a pharmaceutically acceptable salt thereof, a water adduct thereof, a hydrate thereof and a solvate thereof, as well as an agent for the prophylaxis and/or treatment of a disease caused by hyperreactivity of poly(ADP-ribose)polymerase, containing the compound, and a poly(ADP-ribose)polymerase inhibitor containing the compound. In addition, this compound is useful as an agent for the prophylaxis and/or treatment of cerebral infarction, particularly as an agent for the prophylaxis and/or treatment of acute cerebral infarction. Furthermore, this compound is useful as a prophylactic and/or therapeutic agent that improves neurological symptoms associated with cerebral infarction, particularly acute cerebral infarction. wherein the symbols are the same as defined in the description.
摘要翻译： 本发明涉及由下式（I）表示的异喹啉化合物，其光学活性形式，其药学上可接受的盐，其水加合物，其水合物和溶剂化物，以及预防药物 和/或治疗由含有该化合物的聚（ADP-核糖）聚合酶和含该化合物的聚（ADP-核糖）聚合酶抑制剂）的高反应性引起的疾病。 此外，该化合物可用作预防和/或治疗脑梗塞的药剂，特别是作为预防和/或治疗急性脑梗死的药物。 此外，该化合物可用作改善与脑梗死特别是急性脑梗死相关的神经症状的预防和/或治疗剂。 其中符号与描述中定义的相同。
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公开(公告)号：US06288113B1
公开(公告)日：2001-09-11
申请号：US09486312
申请日：2000-06-21
申请人： Yasuhiro Egi , Yoshiji Kubo , Satoru Inoue , Hideaki Kido , Masakuni Nishikawa , Kazutaka Hayashi
发明人： Yasuhiro Egi , Yoshiji Kubo , Satoru Inoue , Hideaki Kido , Masakuni Nishikawa , Kazutaka Hayashi
IPC分类号： A61K31215
CPC分类号： A61K31/727 , A61K31/557 , A61K31/5575 , A61K31/70 , A61K31/715 , A61K38/1825 , A61K45/06 , A61K31/505 , A61K2300/00
摘要： An angiogenesis promoter containing a compound of the following formula (I) wherein R1 is acyl, R2 is alkyl, R3 and R4 are the same or different and each is hydrogen atom or hydroxy protecting group and R5 is alkyl, as an active ingredient. This compound itself not only has an angiogenesis promoting effect but also potentiates the angiogenic effect by a drug (e.g., b-FGF) having such effect. Therefore, it can express the angiogenesis promoting effect more effectively in the ischemic tissues and the site under different disease state, where b-FGF has locally increased.
摘要翻译： 含有下式（I）的化合物的血管生成促进剂作为活性成分，其中R 1为酰基，R 2为烷基，R 3和R 4相同或不同，各自为氢原子或羟基保护基，R 5为烷基。 该化合物本身不仅具有血管生成促进作用，而且还通过具有这种作用的药物（例如b-FGF）增强血管生成作用。 因此，可以在不同疾病状态的缺血组织和部位更有效地表达血管生成促进作用，其中b-FGF局部增加。
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公开(公告)号：US07501412B2
公开(公告)日：2009-03-10
申请号：US10536173
申请日：2003-11-21
申请人： Masakazu Fujio , Hiroyuki Satoh , Shinya Inoue , Toshifumi Matsumoto , Yasuhiro Egi , Taichi Takahashi
发明人： Masakazu Fujio , Hiroyuki Satoh , Shinya Inoue , Toshifumi Matsumoto , Yasuhiro Egi , Taichi Takahashi
IPC分类号： C07D403/02 , A61K31/47
CPC分类号： C07D471/04 , A61K31/472 , A61K31/4725 , A61K31/4745 , A61K31/496 , A61K31/5377 , C07D217/24 , C07D401/04 , C07D401/06 , C07D513/04
摘要： The present invention relates to an isoquinoline compound represented by the following formula (I) or (II), an optically active form thereof, a pharmaceutically acceptable salt thereof, a water adduct thereof, a hydrate thereof and a solvate thereof, as well as an agent for the prophylaxis and/or treatment of a disease caused by hyperreactivity of poly(ADP-ribose)polymerase, containing the compound, and a poly(ADP-ribose)polymerase inhibitor containing the compound. In addition, this compound is useful as an agent for the prophylaxis and/or treatment of cerebral infarction, particularly as an agent for the prophylaxis and/or treatment of acute cerebral infarction.
摘要翻译： 本发明涉及由下式（I）或（II）表示的异喹啉化合物，其光学活性形式，其药学上可接受的盐，其水加合物，其水合物及其溶剂合物，以及 用于预防和/或治疗由含有该化合物的聚（ADP-核糖）聚合酶的高反应性引起的疾病和含该化合物的聚（ADP-核糖）聚合酶抑制剂。 此外，该化合物可用作预防和/或治疗脑梗塞的药剂，特别是作为预防和/或治疗急性脑梗死的药物。
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公开(公告)号：US20060094743A1
公开(公告)日：2006-05-04
申请号：US10536173
申请日：2003-11-21
申请人： Masakazu Fujio , Hiroyuki Satoh , Shinya Inoue , Toshifumi Matsumoto , Yasuhiro Egi , Taichi Takahashi
发明人： Masakazu Fujio , Hiroyuki Satoh , Shinya Inoue , Toshifumi Matsumoto , Yasuhiro Egi , Taichi Takahashi
IPC分类号： A61K31/4745 , A61K31/4709 , C07D471/02 , C07D403/02
CPC分类号： C07D471/04 , A61K31/472 , A61K31/4725 , A61K31/4745 , A61K31/496 , A61K31/5377 , C07D217/24 , C07D401/04 , C07D401/06 , C07D513/04
摘要： The present invention relates to an isoquinoline compound represented by the following formula (I) or (II), an optically active form thereof, a pharmaceutically acceptable salt thereof, a water adduct thereof, a hydrate thereof and a solvate thereof, as well as an agent for the prophylaxis and/or treatment of a disease caused by hyperreactivity of poly(ADP-ribose)polymerase, containing the compound, and a poly(ADP-ribose)polymerase inhibitor containing the compound. In addition, this compound is useful as an agent for the prophylaxis and/or treatment of cerebral infarction, particularly as an agent for the prophylaxis and/or treatment of acute cerebral infarction.
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公开(公告)号：US07812178B2
公开(公告)日：2010-10-12
申请号：US12263963
申请日：2008-11-03
IPC分类号： C07D405/00 , C07D207/00 , C07D207/40
CPC分类号： C07D401/04 , A61K31/4725 , C07D207/12 , C07D401/06 , C07D405/06
摘要： The present invention relates to an isoquinoline compound represented by the following formula (I), an optically active form thereof, a pharmaceutically acceptable salt thereof, a water adduct thereof, a hydrate thereof and a solvate thereof, as well as an agent for the prophylaxis and/or treatment of a disease caused by hyperreactivity of poly(ADP-ribose)polymerase, containing the compound, and a poly(ADP-ribose)polymerase inhibitor containing the compound. In addition, this compound is useful as an agent for the prophylaxis and/or treatment of cerebral infarction, particularly as an agent for the prophylaxis and/or treatment of acute cerebral infarction. Furthermore, this compound is useful as a prophylactic and/or therapeutic agent that improves neurological symptoms associated with cerebral infarction, particularly acute cerebral infarction. wherein the symbols are the same as defined in the description.
摘要翻译： 本发明涉及由下式（I）表示的异喹啉化合物，其光学活性形式，其药学上可接受的盐，其水加合物，其水合物和溶剂化物，以及预防药物 和/或治疗由含有该化合物的聚（ADP-核糖）聚合酶和含该化合物的聚（ADP-核糖）聚合酶抑制剂）的高反应性引起的疾病。 此外，该化合物可用作预防和/或治疗脑梗塞的药剂，特别是作为预防和/或治疗急性脑梗死的药物。 此外，该化合物可用作改善与脑梗死特别是急性脑梗死相关的神经症状的预防和/或治疗剂。 其中符号与描述中定义的相同。
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公开(公告)号：US07459465B2
公开(公告)日：2008-12-02
申请号：US11688103
申请日：2007-03-19
IPC分类号： C07D403/02 , A61K31/47
CPC分类号： C07D401/04 , A61K31/4725 , C07D207/12 , C07D401/06 , C07D405/06
摘要： The present invention relates to an isoquinoline compound represented by the following formula (I), an optically active form thereof, a pharmaceutically acceptable salt thereof, a water adduct thereof, a hydrate thereof and a solvate thereof, as well as an agent for the prophylaxis and/or treatment of a disease caused by hyperreactivity of poly(ADP-ribose)polymerase, containing the compound, and a poly(ADP-ribose)polymerase inhibitor containing the compound. In addition, this compound is useful as an agent for the prophylaxis and/or treatment of cerebral infarction, particularly as an agent for the prophylaxis and/or treatment of acute cerebral infarction. Furthermore, this compound is useful as a prophylactic and/or therapeutic agent that improves neurological symptoms associated with cerebral infarction, particularly acute cerebral infarction. wherein the symbols are the same as defined in the description.
摘要翻译： 本发明涉及由下式（I）表示的异喹啉化合物，其光学活性形式，其药学上可接受的盐，其水加合物，其水合物和溶剂化物，以及预防药物 和/或治疗由含有该化合物的聚（ADP-核糖）聚合酶和含该化合物的聚（ADP-核糖）聚合酶抑制剂）的高反应性引起的疾病。 此外，该化合物可用作预防和/或治疗脑梗塞的药剂，特别是作为预防和/或治疗急性脑梗死的药物。 此外，该化合物可用作改善与脑梗死特别是急性脑梗死相关的神经症状的预防和/或治疗剂。 其中符号与描述中定义的相同。
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公开(公告)号：US06284758B1
公开(公告)日：2001-09-04
申请号：US09486327
申请日：2000-02-25
IPC分类号： A61K3150
CPC分类号： C07D401/12
摘要： An angiogenesis promoter and angiogenesis potentiator containing a pyridazinone compound of the formula (I) wherein each symbol is as defined in the specification, or a pharmacologically acceptable salt thereof, as an active ingredient. The pyridazinone compound (I) and a pharmacologically acceptable salt thereof in the present invention promote angiogenesis and potentiate the angiogenic effect of a drug having such effect, and are useful as an angiogenesis promoter and angiogenesis potentiator.
摘要翻译： 含有式（I）的哒嗪酮化合物的血管生成促进剂和血管生成增强剂，其中每个符号如说明书中所定义，或其药理学上可接受的盐作为活性成分。 本发明中的哒嗪酮化合物（I）及其药理学上可接受的盐促进血管生成并且增强具有这种作用的药物的血管生成作用，并且可用作血管生成促进剂和血管生成增强剂。
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