公开(公告)号：US06689599B1

公开(公告)日：2004-02-10

申请号：US09981953

申请日：2001-10-18

申请人： Lisa A. Racie ,  Natalie C. Twine ,  Michael J. Agostino ,  Neil Wolfman ,  Elisabeth A. Morris

发明人： Lisa A. Racie ,  Natalie C. Twine ,  Michael J. Agostino ,  Neil Wolfman ,  Elisabeth A. Morris

IPC分类号： C12N964

CPC分类号： C12N9/6421

摘要： Aggrecanase proteins and the nucleotides sequences encoding them as well as processes for producing them are disclosed. Methods for developing inhibitors of the aggrecanase enzymes and antibodies to the enzymes for treatment of conditions characterized by the degradation of aggrecan are also disclosed.

摘要翻译： 公开了聚集蛋白聚糖蛋白和编码它们的核苷酸序列以及其生产方法。 还公开了开发聚蛋白聚糖酶的抑制剂的方法和用于治疗以聚集蛋白聚糖降解为特征的病症的酶的抗体的方法。