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公开(公告)号：US5965397A
公开(公告)日：1999-10-12
申请号：US14969
申请日：1998-01-28
申请人： Kenneth Jacobs , John M. McCoy , Edward R. LaVallie , Lisa A. Racie , David Merberg , Maurice Treacy , Vikki Spaulding , Michael J. Agostino
发明人： Kenneth Jacobs , John M. McCoy , Edward R. LaVallie , Lisa A. Racie , David Merberg , Maurice Treacy , Vikki Spaulding , Michael J. Agostino
IPC分类号： C12N15/09 , A61K38/00 , A61K48/00 , A61P3/04 , A61P7/00 , A61P7/02 , A61P15/08 , A61P17/02 , A61P19/08 , A61P25/16 , A61P25/24 , A61P25/28 , A61P29/00 , A61P35/00 , A61P37/02 , C07K14/47 , C12N5/10 , C12N15/12 , C12N15/00
CPC分类号： C07K14/47
摘要： Novel polynucleotides and the proteins encoded thereby are disclosed.
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公开(公告)号：US06706869B1
公开(公告)日：2004-03-16
申请号：US09311021
申请日：1999-05-13
IPC分类号： C07H2104
摘要： Novel polynucleotides and the proteins encoded thereby are disclosed.
摘要翻译： 公开了新的多核苷酸和由此编码的蛋白质。
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公开(公告)号：US06451318B1
公开(公告)日：2002-09-17
申请号：US09625918
申请日：2000-07-26
申请人： Kenneth Jacobs , John M. McCoy , Lisa A. Racie , Edward R. La Vallie , David Merberg , Maurice Treacy , Vikki Spaulding , Michael J. Agostino
发明人： Kenneth Jacobs , John M. McCoy , Lisa A. Racie , Edward R. La Vallie , David Merberg , Maurice Treacy , Vikki Spaulding , Michael J. Agostino
IPC分类号： A61K3900
摘要： Novel proteins are disclosed.
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公开(公告)号：US07125701B2
公开(公告)日：2006-10-24
申请号：US10205368
申请日：2002-07-26
申请人： Michael J. Agostino , Lisa A. Racie
发明人： Michael J. Agostino , Lisa A. Racie
CPC分类号： C12N9/6421
摘要： Novel aggrecanase proteins and the nucleotide sequences encoding them as well as processes for producing them are disclosed. Methods for developing inhibitors of the aggrecanase enzymes and antibodies to the enzymes for treatment of conditions characterized by the degradation of aggrecan are also disclosed.
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公开(公告)号：US06689599B1
公开(公告)日：2004-02-10
申请号：US09981953
申请日：2001-10-18
IPC分类号： C12N964
CPC分类号： C12N9/6421
摘要： Aggrecanase proteins and the nucleotides sequences encoding them as well as processes for producing them are disclosed. Methods for developing inhibitors of the aggrecanase enzymes and antibodies to the enzymes for treatment of conditions characterized by the degradation of aggrecan are also disclosed.
摘要翻译： 公开了聚集蛋白聚糖蛋白和编码它们的核苷酸序列以及其生产方法。 还公开了开发聚蛋白聚糖酶的抑制剂的方法和用于治疗以聚集蛋白聚糖降解为特征的病症的酶的抗体的方法。
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公开(公告)号：US5976838A
公开(公告)日：1999-11-02
申请号：US993228
申请日：1997-12-18
申请人： Kenneth Jacobs , John M. McCoy , Edward R. LaVallie , Lisa A. Racie , David Merberg , Maurice Treacy , Vikki Spaulding , Michael J. Agostino
发明人： Kenneth Jacobs , John M. McCoy , Edward R. LaVallie , Lisa A. Racie , David Merberg , Maurice Treacy , Vikki Spaulding , Michael J. Agostino
IPC分类号： C12N15/09 , A61K38/00 , A61K48/00 , A61P7/00 , A61P19/08 , A61P35/00 , A61P37/00 , A61P43/00 , C07K14/47 , C12N5/10 , C12P21/02 , C12N15/00
CPC分类号： C07K14/47
摘要： Novel polynucleotides and the proteins encoded thereby are disclosed.
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公开(公告)号：US5976837A
公开(公告)日：1999-11-02
申请号：US960022
申请日：1997-10-29
申请人： Kenneth Jacobs , John M. McCoy , Edward R. LaVallie , Lisa A. Racie , David Merberg , Maurice Treacy , Vikki Spaulding , Michael J. Agostino
发明人： Kenneth Jacobs , John M. McCoy , Edward R. LaVallie , Lisa A. Racie , David Merberg , Maurice Treacy , Vikki Spaulding , Michael J. Agostino
IPC分类号： C12N15/09 , A61K38/00 , A61K48/00 , A61P1/02 , A61P7/02 , A61P7/04 , A61P17/02 , A61P19/02 , A61P19/08 , A61P21/00 , C07K14/47 , C12N5/10 , C12N15/12 , C12P21/02 , C12N15/00
CPC分类号： C07K14/47
摘要： Novel polynucleotides and the proteins encoded thereby are disclosed.
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公开(公告)号：US20080139452A1
公开(公告)日：2008-06-12
申请号：US12000468
申请日：2007-12-13
申请人： Kenneth Jacobs , John M. McCoy , Edward R. LaVallie , Lisa A. Collins-Racie , David Merberg , Michael J. Agostino , Robert Steininger , Vikki Spaulding , Gordon G. Wong , Hilary F. Clark , Kim Fechtel , Cheryl Evans , Maurice Treacy
发明人： Kenneth Jacobs , John M. McCoy , Edward R. LaVallie , Lisa A. Collins-Racie , David Merberg , Michael J. Agostino , Robert Steininger , Vikki Spaulding , Gordon G. Wong , Hilary F. Clark , Kim Fechtel , Cheryl Evans , Maurice Treacy
CPC分类号： C07K16/18 , A61K38/00 , C07K14/435 , C07K14/47
摘要： Novel polynucleotides and the proteins encoded thereby are disclosed.
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公开(公告)号：US07344861B2
公开(公告)日：2008-03-18
申请号：US11395249
申请日：2006-04-03
申请人： Kenneth Jacobs , John M. McCoy , Edward R. LaVallie , Lisa A. Collins-Racie , David Merberg , Michael J. Agostino , Robert J. Steininger, II , Vikki Spaulding , Gordon G. Wong , Hilary F. Clark , Kim Fechtel , Cheryl Evans , Maurice Treacy
发明人： Kenneth Jacobs , John M. McCoy , Edward R. LaVallie , Lisa A. Collins-Racie , David Merberg , Michael J. Agostino , Robert J. Steininger, II , Vikki Spaulding , Gordon G. Wong , Hilary F. Clark , Kim Fechtel , Cheryl Evans , Maurice Treacy
CPC分类号： C07K16/18 , A61K38/00 , C07K14/435 , C07K14/47
摘要： Novel polynucleotides and the proteins encoded thereby are disclosed.
摘要翻译： 公开了新的多核苷酸和由此编码的蛋白质。
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公开(公告)号：US07078217B2
公开(公告)日：2006-07-18
申请号：US10354983
申请日：2003-01-31
申请人： Christopher J. Corcoran , Michael J. Agostino , Edward R. LaVallie , Carl R. Flannery , Lisa A. Collins-Racie
发明人： Christopher J. Corcoran , Michael J. Agostino , Edward R. LaVallie , Carl R. Flannery , Lisa A. Collins-Racie
CPC分类号： C12N9/6421 , A61K2039/505
摘要： Novel aggrecanase proteins and the nucleotide sequences encoding them as well as processes for producing them are disclosed. Methods of identifying and developing inhibitors of the aggrecanase enzymes and antibodies to the enzymes for treatment of conditions characterized by the degradation of aggrecan are also disclosed.
摘要翻译： 公开了新型聚蛋白聚糖蛋白聚糖蛋白和编码它们的核苷酸序列以及其制备方法。 还公开了鉴定和发展聚蛋白聚糖蛋白酶的抑制剂和用于治疗由聚集蛋白聚糖蛋白降解特征的病症的酶的抗体的方法。
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