公开(公告)号：US08209025B1

公开(公告)日：2012-06-26

申请号：US13217697

申请日：2011-08-25

申请人： Aniket Saoji ,  Leonid M. Litvak

发明人： Aniket Saoji ,  Leonid M. Litvak

IPC分类号： A61N1/06

CPC分类号： A61N1/36036

摘要： Methods of optimizing stimulation current applied to a cochlear implant patient include determining a plurality of narrowband spectral modulation detection thresholds for the patient and adjusting a stimulation current applied to the patient in accordance with the narrowband spectral modulation detection thresholds. Systems for optimizing stimulation current applied to a cochlear implant patient include an electrode array having a plurality of electrodes disposed thereon, an implantable cochlear stimulator coupled to the electrode array and configured to apply a stimulation current to one or more locations along a cochlea of a patient via one or more of the electrodes, and a fitting station communicatively coupled to the implantable cochlear stimulator. The fitting station is configured determine a plurality of narrowband spectral modulation detection thresholds and adjust the stimulation current in accordance with the narrowband spectral modulation detection thresholds.

公开(公告)号：US08170679B2

公开(公告)日：2012-05-01

申请号：US12765649

申请日：2010-04-22

申请人： Aniket Saoji ,  Leonid M. Litvak ,  Gene Y. Fridman

发明人： Aniket Saoji ,  Leonid M. Litvak ,  Gene Y. Fridman

IPC分类号： A61N1/00

CPC分类号： H04R25/70 ,  A61N1/36036

摘要： Psychophysical tests are administered to cochlear implant (CI) users to determine a spectral modulation transfer function (SMTF), smallest detectable spectral contrast as a function of spectral modulation frequency, for each individual CI user. The determined SMTF for individual CI user is compared against a SMTF of a normal hearing person to determine the specific enhancements needed. A profile of spectral enhancement achievable with variation of filter parameters, sigma and maximum that best fits the needed enhancements for the individual CI user is selected. Based on the corresponding sigma and maximum selected, a sound processing strategy is adjusted to provide customized spectral contrast enhancement for the individual CI user. The sound processing strategy implemented includes an outer hair cell model.

摘要翻译： 对于每个个体CI用户，对耳蜗植入（CI）用户施加心理物理测试以确定频谱调制传递函数（SMTF），作为频谱调制频率的函数的最小可检测频谱对比度。 将针对个人CI用户的确定的SMTF与正常听力者的SMTF进行比较，以确定所需的特定增强。 选择可以通过滤波器参数，西格玛和最大值的变化实现的最佳匹配单个CI用户所需增强的频谱增强曲线。 基于相应的西格玛和最大选择，调整声音处理策略，为个人CI用户提供定制的光谱对比度增强。 实施的声音处理策略包括外毛细胞模型。

公开(公告)号：US08121698B2

公开(公告)日：2012-02-21

申请号：US12728722

申请日：2010-03-22

申请人： Gene Y. Fridman ,  Leonid M. Litvak

发明人： Gene Y. Fridman ,  Leonid M. Litvak

IPC分类号： A61N1/08

CPC分类号： H04S3/002 ,  A61N1/36036 ,  G10L21/02 ,  G10L2021/065

摘要： Contrast between various frequency components of sound is enhanced through a lateral suppression strategy to provide increased speech perception in the electrically stimulated cochlea. A received audio signal is divided into a plurality of input signals, wherein each input signal is associated with a frequency band. A plurality of envelope signals are generated by determining the envelope of each of a plurality of the input signals. At least one of the envelope signals is scaled in accordance with a scaling factor to generate at least one scaled envelope signal. An output signal is generated by combining at least one envelope signal with at least one scaled envelope signal, and the cochlea is stimulated based on the generated output signal. The lateral suppression strategy can be applied to one or more frequency bands using scaled amplitude signals associated with one or more neighboring frequency bands.

摘要翻译： 通过横向抑制策略来增强声音的各种频率分量之间的对比，以在电刺激的耳蜗中提供增加的语音感知。 接收到的音频信号被分成多个输入信号，其中每个输入信号与频带相关联。 通过确定多个输入信号中的每一个的包络来生成多个包络信号。 根据缩放因子来缩放包络信号中的至少一个，以产生至少一个缩放的包络信号。 通过将至少一个包络信号与至少一个缩放的包络信号组合来产生输出信号，并且基于所生成的输出信号来刺激耳蜗。 横向抑制策略可以使用与一个或多个相邻频带相关联的缩放振幅信号应用于一个或多个频带。

公开(公告)号：US20110319965A1

公开(公告)日：2011-12-29

申请号：US13225981

申请日：2011-09-06

申请人： Gene Y. Fridman ,  Leonid M. Litvak

发明人： Gene Y. Fridman ,  Leonid M. Litvak

IPC分类号： A61F11/04

CPC分类号： A61N1/36036

摘要： Optimizing pitch allocation in a cochlear stimulation system may include implanting an electrode array having a plurality of electrodes into the cochlea of a patient, where the electrode array has an associated implant fitting characteristic that defines a relationship between the implanted electrode array and audio frequencies, presenting sounds through the electrode array to the patient, receiving from the patient a selection of one of the sounds that most closely conforms to a single note, and determining a slope of the implant fitting characteristic of the electrode array based on the sound selected by the patient. Each sound may include a fundamental frequency and one or more harmonics. The optimization may also include changing a center frequency of a band pass filter associated with each electrode based on the determined slope.

摘要翻译： 在耳蜗刺激系统中优化音调分配可以包括将具有多个电极的电极阵列植入到患者的耳蜗中，其中电极阵列具有限定植入的电极阵列和音频之间的关系的相关联的植入拟合特征，呈现 通过电极阵列向患者发出声音，从患者接收最接近于单个音符的声音之一的选择，以及基于由患者选择的声音来确定电极阵列的植入物拟合特征的斜率 。 每个声音可以包括基频和一个或多个谐波。 优化还可以包括基于确定的斜率改变与每个电极相关联的带通滤波器的中心频率。

公开(公告)号：US08027734B1

公开(公告)日：2011-09-27

申请号：US12059358

申请日：2008-03-31

申请人： Aniket Saoji ,  Leonid M. Litvak

发明人： Aniket Saoji ,  Leonid M. Litvak

IPC分类号： A61N1/08

CPC分类号： A61N1/36036

摘要： Methods of optimizing stimulation current applied to a cochlear implant patient include determining a plurality of narrowband spectral modulation detection thresholds for the patient and adjusting a stimulation current applied to the patient in accordance with the narrowband spectral modulation detection thresholds. Systems for optimizing stimulation current applied to a cochlear implant patient include an electrode array having a plurality of electrodes disposed thereon, an implantable cochlear stimulator coupled to the electrode array and configured to apply a stimulation current to one or more locations along a cochlea of a patient via one or more of the electrodes, and a fitting station communicatively coupled to the implantable cochlear stimulator. The fitting station is configured determine a plurality of narrowband spectral modulation detection thresholds and adjust the stimulation current in accordance with the narrowband spectral modulation detection thresholds.

摘要翻译： 优化施加到耳蜗植入患者的刺激电流的方法包括确定患者的多个窄带频谱调制检测阈值，并根据窄带频谱调制检测阈值调整施加到患者的刺激电流。 用于优化施加到耳蜗植入物患者的刺激电流的系统包括具有布置在其上的多个电极的电极阵列，耦合到电极阵列并被配置为将刺激电流施加到沿着患者的耳蜗的一个或多个位置的可植入耳蜗刺激器 通过一个或多个电极，以及通信地耦合到可植入耳蜗刺激器的装配台。 配置站配置确定多个窄带频谱调制检测阈值，并根据窄带频谱调制检测阈值调整刺激电流。

公开(公告)号：US07729775B1

公开(公告)日：2010-06-01

申请号：US11386198

申请日：2006-03-21

申请人： Aniket Saoji ,  Leonid M. Litvak ,  Gene Y. Fridman

发明人： Aniket Saoji ,  Leonid M. Litvak ,  Gene Y. Fridman

IPC分类号： A61N1/00

CPC分类号： H04R25/70 ,  A61N1/36036

摘要： Psychophysical tests are administered to cochlear implant (CI) users to determine a spectral modulation transfer function (SMTF), the smallest detectable spectral contrast as a function of spectral modulation frequency, for each individual CI user. The determined SMTF for individual CI user is compared against a SMTF of a normal hearing person to determine the specific enhancements needed. A spectral contrast enhancement that best fits the needed enhancements for the individual CI user is selected, and a sound processing strategy is adjusted to provide customized spectral contrast enhancement for the individual CI user. The sound processing strategy implemented includes an outer hair cell model.

摘要翻译： 对于耳蜗植入物（CI）用户进行心理物理测试，以确定每个CI用户的频谱调制传递函数（SMTF），其作为频谱调制频率的函数的最小可检测频谱对比度。 将针对个人CI用户的确定的SMTF与正常听力者的SMTF进行比较，以确定所需的特定增强。 选择最适合个人CI用户所需增强的光谱对比度增强，并且调整声音处理策略以为个体CI用户提供定制的光谱对比度增强。 实施的声音处理策略包括外毛细胞模型。

公开(公告)号：US20180304069A1

公开(公告)日：2018-10-25

申请号：US15768492

申请日：2015-11-03

申请人： Kanthaiah KOKA ,  Leonid M. LITVAK ,  ADVANCED BIONICS AG

发明人： Kanthaiah Koka ,  Leonid M. Litvak

IPC分类号： A61N1/05 ,  A61N1/36

CPC分类号： A61N1/0541 ,  A61B5/04845 ,  A61N1/36036

摘要： An exemplary monitoring system 1) receives a user input command to begin monitoring evoked responses that occur in response to acoustic stimulation during an insertion procedure in which a lead that is communicatively coupled to a cochlear implant is inserted into a cochlea of a patient, the lead having an array of intracochlear electrodes and an extracochlear electrode, the extracochlear electrode physically and communicatively coupled to a probe that is also communicatively coupled to the monitoring system, 2) directs, in response to the user input command, the cochlear implant to short an intracochlear electrode with the extracochlear electrode, 3) presents the acoustic stimulation to the patient, and 4) records the evoked responses that occur in response to the acoustic stimulation by using the intracochlear electrode to detect signals representative of the evoked responses and receiving the detected signals by way of the extracochlear electrode and the probe.

公开(公告)号：US08509907B2

公开(公告)日：2013-08-13

申请号：US13425770

申请日：2012-03-21

申请人： Leonid M. Litvak ,  Aniket Saoji

发明人： Leonid M. Litvak ,  Aniket Saoji

IPC分类号： A61N1/00

CPC分类号： A61N1/36032 ,  A61N1/0541 ,  A61N1/36036

摘要： An exemplary method includes 1) applying a main current to a first electrode disposed within a patient and associated with a first pitch, 2) concurrently applying a compensation current to a second electrode disposed within the patient and associated with a second pitch during the application of the main current, the compensation current being out-of-phase with the main current, and 3) optimizing an amount of the compensation current to result in a target pitch being presented to the patient that is distanced from the first pitch in a pitch direction opposite a pitch direction of the second pitch in relation to the first pitch. Corresponding methods and systems are also disclosed.

摘要翻译： 一种示例性方法包括：1）将主电流施加到设置在患者体内并与第一间距相关联的第一电极; 2）在应用期间同时向布置在患者体内的第二电极施加补偿电流，并与第二电极相关联 主电流，补偿电流与主电流异相，以及3）优化补偿电流的量以导致目标音调被呈现给在间距方向上与第一音调间隔的患者 相对于第一间距与第二间距的俯仰方向相反。 还公开了相应的方法和系统。

公开(公告)号：US08321026B2

公开(公告)日：2012-11-27

申请号：US12556972

申请日：2009-09-10

申请人： Aniket Saoji ,  Leonid M. Litvak

发明人： Aniket Saoji ,  Leonid M. Litvak

IPC分类号： A61N1/05

CPC分类号： A61N1/36036 ,  A61B5/121 ,  A61N1/37247

摘要： Methods and systems of spectral tilt optimization for a cochlear implant patient include applying electrical stimulation representative of an audio signal to a patient in accordance with a spectral tilt value and optimizing the spectral tilt value in response to a measured ability of the patient to recognize at least one attribute of the audio signal.

摘要翻译： 用于耳蜗植入患者的频谱倾斜优化的方法和系统包括根据频谱倾斜值将表示音频信号的电刺激应用于患者，并响应于患者的测量能力至少识别至少 音频信号的一个属性。

公开(公告)号：US20120197346A1

公开(公告)日：2012-08-02

申请号：US13444655

申请日：2012-04-11

申请人： Leonid M. Litvak ,  Lakshmi N. Mishra

发明人： Leonid M. Litvak ,  Lakshmi N. Mishra

IPC分类号： A61F11/04 ,  A61N1/36

CPC分类号： A61N1/37247 ,  A61N1/36036 ,  H04R2225/67

摘要： Errors in pitch allocation within a cochlear implant are corrected in order to provide a significant and profound improvement in the quality of sound perceived by the cochlear implant user. The disclosure provides a tool for determining the implant fitting curve for cochlear implant system to correct pitch warping. The method presents familiar musical tunes to determine the implant fitting slope (relative alignment). In addition, in one embodiment, speech sounds may be used to determine the offset of the fitting line (absolute alignment). The use of music and speech to determine the implant fitting curve (line) and the slope is facilitated by using techniques to implement virtual electrodes to more precisely direct stimuli to the location or “place” on the cochlea.

摘要翻译： 修正耳蜗植入物内音调分配的错误，以便对耳蜗植入物使用者感知到的声音质量进行显着和深刻的改进。 本公开提供了一种用于确定用于人工耳蜗植入系统的植入物拟合曲线以校正间距翘曲的工具。 该方法呈现熟悉的音乐曲调以确定植入物拟合斜率（相对对准）。 此外，在一个实施例中，可以使用语音来确定拟合线的偏移（绝对对准）。 通过使用技术来实现虚拟电极以更精确地将刺激直接引导到耳蜗上的位置或“位置”来促进使用音乐和言语来确定植入物拟合曲线（线）和斜率。