公开(公告)号：US20180318229A1

公开(公告)日：2018-11-08

申请号：US15995889

申请日：2018-06-01

Applicant: ModernaTX, Inc.

Inventor： Joshua FREDERICK ,  Ailin BAI ,  Vladimir PRESNYAK ,  Stephen HOGE ,  Kerry BENENATO ,  Iain MCFADYEN ,  Ellalahewage Sathyajith KUMARASINGHE ,  Susannah HEWITT

IPC: A61K9/51 ,  A61P35/00 ,  A61K38/20 ,  A61K38/17 ,  C07K14/54 ,  C07K14/705 ,  A61K39/395 ,  A61K9/00

CPC classification number: A61K9/5123 ,  A61K9/00 ,  A61K9/0019 ,  A61K9/1272 ,  A61K9/5146 ,  A61K38/177 ,  A61K38/1774 ,  A61K38/20 ,  A61K38/2006 ,  A61K38/208 ,  A61K38/2086 ,  A61K39/39 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  A61K2039/51 ,  A61K2039/53 ,  A61K2039/54 ,  A61K2039/545 ,  A61K2039/585 ,  A61P35/00 ,  B82Y5/00 ,  C07K14/54 ,  C07K14/5434 ,  C07K14/5443 ,  C07K14/5446 ,  C07K14/545 ,  C07K14/70575 ,  C07K2319/00 ,  C12N15/88 ,  A61K2300/00

Abstract: The disclosure relates to compositions and methods for the preparation, manufacture and therapeutic use of combinations of immunomodulatory polynucleotides (e.g., mRNAs) encoding an immune response primer polypeptide (e.g., an interleukin 23 (IL-23) polypeptide or an interleukin 36γ (IL-36-gamma) polypeptide), and an immune response co-stimulatory signal polypeptide (e.g., an OX40L polypeptide).