公开(公告)号：US5139248A

公开(公告)日：1992-08-18

申请号：US651569

申请日：1991-02-06

申请人： Toshiaki Kishine ,  Mikio Yoshikawa ,  Hidetoshi Ito ,  Hiroyuki Takano ,  Masatoshi Yasuda

发明人： Toshiaki Kishine ,  Mikio Yoshikawa ,  Hidetoshi Ito ,  Hiroyuki Takano ,  Masatoshi Yasuda

IPC分类号： B65H45/109 ,  B65H45/20

CPC分类号： B65H45/109 ,  B65H45/20

摘要： The present invention relates to a printed paper folding apparatus comprising: conveyor means provided from the upstream side of a folded paper conveying path located below a folder unit to a folded paper cutting position on the downstream side thereof so as to convey a sheet of printed paper which is folded and discharged by the folder unit in a zigzag fashion; a folded paper separating position indicating device provided along the paper conveying path so as to indicate separating positions at intervals of a predetermined number of folds of the printed paper which is folded and discharged by the folder unit; a folder paper cutting device provided by the cutting position so as to automatically cut the paper, which is continuously conveyed by the conveyor means along the conveying path, into an upstream portion and a downstream portion relative to the conveying path; and a paper sorting device provided near the cutting position so as to automatically sort the upstream portion of the paper from the downstream portion thereof.

公开(公告)号：US4987129A

公开(公告)日：1991-01-22

申请号：US222404

申请日：1988-07-21

申请人： Shigeo Shimizu ,  Hiroyuki Takano

发明人： Shigeo Shimizu ,  Hiroyuki Takano

IPC分类号： A63B69/02 ,  A61K31/545 ,  C07D487/04 ,  C07D519/00

CPC分类号： C07D519/00 ,  Y02P20/55

摘要： There are disclosed a .beta.-lactam compound represented by the formula (I): ##STR1## wherein R.sub.1 represents an acyl group; M represents a hydrogen atom, a protective group or an eliminatable group which is easily hydrolyzable in a human body; B represents a group represented by the formula (b): ##STR2## where at least one of R.sub.2, R.sub.3 and R.sub.9 represent a group represented by the formula: --A--OR.sub.4 where R.sub.4 represents a hydrogen or a lower alkyl group; and A represents a straight or branched alkylene group having 1 to 6 carbon atoms; and a remaining group or groups are each independently a hydrogen atom; a cyano group; a lower alkyl group which may be substituted by a halogen atom; a carbamoyl group which may be substituted by a lower alkyl group; a cycloalkyl group; or a carboxyl group which may be substituted by a protective group or an eliminatable group which is easily hydrolyzable in a human body, and also when R.sub.9 is --A--OR.sub.4, and R.sub.3 may be combined with each other to form an alkylene group having 3 to 4 carbon atoms; and Z represents a nitrogen atom or a group represented by the formula: C--R.sub.10 where R.sub.10 represents a hydrogen atom, a carboxyl group or a lower alkyl group which may be substituted by a hydroxy group or a lower alkoxy group,or its pharmaceutically acceptable salt, and a process for preparing the same, an intermediate for synthesis of the same and a medicinal composition for bacterially infectious disease therapy containing the same.

摘要翻译： 公开了由式（I）表示的β-内酰胺化合物：其中R 1表示酰基; M表示氢原子，可在人体中容易水解的保护基或可消除基团; B表示由式（b）表示的基团：其中R 2，R 3和R 9中的至少一个表示由下式表示的基团：-A-OR 4，其中R 4表示氢或低级烷基; A表示碳原子数1〜6的直链或支链亚烷基。 剩余的基团各自独立地为氢原子; 氰基; 可被卤素原子取代的低级烷基; 可被低级烷基取代的氨基甲酰基; 环烷基; 或可以被保护基团取代的羧基或可在人体中容易水解的可消除基团，当R 9为-A-OR 4时，R 2和R 3可以相互结合形成亚烷基， 3至4个碳原子; Z表示氮原子或由式C-R 10表示的基团，其中R 10表示氢原子，可以被羟基或低级烷氧基取代的羧基或低级烷基，或其药学上可接受的 盐及其制备方法，其合成中间体和含有该盐的细菌感染性疾病治疗用药物组合物。

公开(公告)号：US4958019A

公开(公告)日：1990-09-18

申请号：US357172

申请日：1989-05-26

申请人： Shigeo Shimizu ,  Hiroyuki Takano

发明人： Shigeo Shimizu ,  Hiroyuki Takano

IPC分类号： A63B69/02 ,  A61K31/545 ,  C07D487/04 ,  C07D519/00

CPC分类号： C07D519/00 ,  Y02P20/55

摘要： There are disclosed a .beta.-lactam compound represented by the formula (I): ##STR1## wherein R.sub.1 represents an acyl group; M represents a hydrogen atom, a protective group or an eliminatable group which is easily hydrolyzable in a human body; B represents a group represented by the formula (b): ##STR2## where at least one of R.sub.2, R.sub.3 and R.sub.9 represent a group represented by the formula: --A--OR.sub.4 where R.sub.4 represents a hydrogen or a lower alkyl group; and A represents a straight or branced alkylene group having 1 to 6 carbon atoms; and a remaining group or groups are each independently a hydrogen atom; a cyano group; a lower alkyl group which may be substituted by a halogen atom; a carbamoyl group which may be substituted by a lower alkyl group; a cycloalkyl group; or a carboxyl group which may be substituted by a protective group or an eliminatable group which is easily hydrolyzable in a human body, and also when R.sub.9 is --A--OR.sub.4, R.sub.2 and R.sub.3 may be combined with each other to form an alkylene group having 3 to 4 carbon atoms; and Z represents a nitrogen atom or a group represented by the formula: C--R.sub.10 where R.sub.10 represents a hydrogen atom, a carboxyl group or a lower alkyl group which may be substituted by a hydroxy group or a lower alkoxy group,or its pharmaceutically acceptable salt, and a process for preparing the same, an intermediate for synthesis of the same and a medicinal composition for bacterially infectious disease therapy containing the same.

摘要翻译： 公开了由式（I）表示的β-内酰胺化合物：其中R 1表示酰基; M表示氢原子，可在人体中容易水解的保护基或可消除基团; B表示由式（b）表示的基团：其中R 2，R 3和R 9中的至少一个表示由下式表示的基团：-A-OR 4，其中R 4表示氢或低级烷基; A表示碳原子数1〜6的直链或支链亚烷基。 剩余的基团各自独立地为氢原子; 氰基; 可被卤素原子取代的低级烷基; 可被低级烷基取代的氨基甲酰基; 环烷基; 或可以被保护基团取代的羧基或可在人体中容易水解的可消除基团，当R 9为-A-OR 4时，R 2和R 3可以相互结合形成亚烷基， 3至4个碳原子; Z表示氮原子或由式C-R 10表示的基团，其中R 10表示氢原子，可以被羟基或低级烷氧基取代的羧基或低级烷基，或其药学上可接受的 盐及其制备方法，其合成中间体和含有该盐的细菌感染性疾病治疗用药物组合物。