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公开(公告)号：US07910608B2
公开(公告)日：2011-03-22
申请号：US11879835
申请日：2007-07-19
申请人： Mathai Mammen , Yu-Hua Ji , YongQi Mu , Craig Husfeld , Li Li
发明人： Mathai Mammen , Yu-Hua Ji , YongQi Mu , Craig Husfeld , Li Li
IPC分类号： A61K31/445 , C07D221/08
CPC分类号： C07D211/62 , A61K9/124 , A61K9/1623 , A61K9/1652 , A61K31/4545 , A61K45/06 , C07D401/12
摘要： This invention provides compounds of formula I: wherein a, b, c, d, m, n, p, s, t, W, Ar1, R1, R2, R3, R4, R6, R7, and R8 are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.
摘要翻译： 本发明提供式I化合物：其中a，b，c，d，m，n，p，s，t，W，Ar1，R1，R2，R3，R4，R6，R7和R8如 规范。 式I化合物是毒蕈碱受体拮抗剂。 本发明还提供含有这些化合物的药物组合物，用于制备这些化合物的方法和中间体以及使用这些化合物治疗肺部疾病的方法。
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公开(公告)号：US07683173B2
公开(公告)日：2010-03-23
申请号：US12265091
申请日：2008-11-05
申请人： Yu-Hua Ji , Craig Husfeld , Mathai Mammen , YongQi Mu , Eric L. Stangeland
发明人： Yu-Hua Ji , Craig Husfeld , Mathai Mammen , YongQi Mu , Eric L. Stangeland
IPC分类号： C07D211/02 , C07D409/00 , C07D405/00
CPC分类号： C07D211/58 , C07D211/46 , C07D211/62 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D487/08 , C07D487/10
摘要： The invention provides compounds of formula I: wherein a, b, c, d, f, W, Q, Y, R1, R2, and R3 are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.
摘要翻译： 本发明提供式I化合物：其中a，b，c，d，f，W，Q，Y，R 1，R 2和R 3如说明书中所定义。 式I化合物是毒蕈碱受体拮抗剂。 本发明还提供含有这些化合物的药物组合物，用于制备这些化合物的方法和中间体以及使用这些化合物治疗肺部疾病的方法。
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公开(公告)号：US20100041701A1
公开(公告)日：2010-02-18
申请号：US12582865
申请日：2009-10-21
申请人： Yu-Hua Ji , Craig Husfeld , Li Li , Mathai Mammen , YongQi Mu , Eric L. Stangeland
发明人： Yu-Hua Ji , Craig Husfeld , Li Li , Mathai Mammen , YongQi Mu , Eric L. Stangeland
IPC分类号： A61K31/4545 , C07D211/94 , C07D401/14 , A61K31/454 , A61P9/10
CPC分类号： C07D405/14 , C07D211/62 , C07D401/12 , C07D409/14
摘要： The invention provides compounds of formula I: wherein a, b, c, d, n, R1, R2, R3, R6, R7, W, and A are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.
摘要翻译： 本发明提供式I化合物：其中a，b，c，d，n，R 1，R 2，R 3，R 6，R 7，W和A如说明书中所定义。 式I化合物是毒蕈碱受体拮抗剂。 本发明还提供含有这些化合物的药物组合物，用于制备这些化合物的方法和中间体以及使用这些化合物治疗肺部疾病的方法。
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公开(公告)号：US07629336B2
公开(公告)日：2009-12-08
申请号：US11371512
申请日：2006-03-09
申请人： Yu-Hua Ji , Craig Husfeld , Li Li , Mathai Mammen , YongQi Mu , Eric L. Stangeland
发明人： Yu-Hua Ji , Craig Husfeld , Li Li , Mathai Mammen , YongQi Mu , Eric L. Stangeland
IPC分类号： C07D211/44 , C07D401/10 , C07D401/12 , A61K31/435
CPC分类号： C07D405/14 , C07D211/62 , C07D401/12 , C07D409/14
摘要： The invention provides compounds of formula I: wherein a, b, c, d, n, R1, R2, R3, R6, R7, W, and A are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.
摘要翻译： 本发明提供式I化合物：其中a，b，c，d，n，R 1，R 2，R 3，R 6，R 7，W和A如说明书中所定义。 式I化合物是毒蕈碱受体拮抗剂。 本发明还提供含有这些化合物的药物组合物，用于制备这些化合物的方法和中间体以及使用这些化合物治疗肺部疾病的方法。
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公开(公告)号：US20090226379A1
公开(公告)日：2009-09-10
申请号：US12437766
申请日：2009-05-08
申请人： Mathai Mammen , Yu-Hua Ji , YongQi Mu , Craig Husfeld , Li Li
发明人： Mathai Mammen , Yu-Hua Ji , YongQi Mu , Craig Husfeld , Li Li
IPC分类号： A61K31/4545 , A61K31/573 , A61K31/58
CPC分类号： C07D211/62 , A61K9/124 , A61K9/1623 , A61K9/1652 , A61K31/4545 , A61K45/06 , C07D401/12
摘要： This invention provides compounds of formula I: wherein a, b, c, d, m, n, p, s, t, W, Ar1, R1, R2, R3, R4, R6, R7, and R8 are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.
摘要翻译： 本发明提供式I化合物：其中a，b，c，d，m，n，p，s，t，W，Ar1，R1，R2，R3，R4，R6，R7和R8如 规范。 式I化合物是毒蕈碱受体拮抗剂。 本发明还提供含有这些化合物的药物组合物，用于制备这些化合物的方法和中间体以及使用这些化合物治疗肺部疾病的方法。
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公开(公告)号：US07585879B2
公开(公告)日：2009-09-08
申请号：US11879996
申请日：2007-07-19
申请人： Mathai Mammen , Yu-Hua Ji , YongQi Mu , Craig Husfeld , Li Li
发明人： Mathai Mammen , Yu-Hua Ji , YongQi Mu , Craig Husfeld , Li Li
IPC分类号： A61K31/445 , C07D401/00
CPC分类号： C07D211/62 , A61K9/124 , A61K9/1623 , A61K9/1652 , A61K31/4545 , A61K45/06 , C07D401/12
摘要： This invention provides compounds of formula I: wherein a, b, c, d, m, n, p, s, t, W, Ar1, R1, R2, R3, R4, R6, R7, and R8 are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.
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公开(公告)号：US07491736B2
公开(公告)日：2009-02-17
申请号：US11880007
申请日：2007-07-19
申请人： Mathai Mammen , Yu-Hua Ji , YongQi Mu , Craig Husfeld , Li Li
发明人： Mathai Mammen , Yu-Hua Ji , YongQi Mu , Craig Husfeld , Li Li
IPC分类号： A61K31/445 , C07D421/00
CPC分类号： C07D211/62 , A61K9/124 , A61K9/1623 , A61K9/1652 , A61K31/4545 , A61K45/06 , C07D401/12
摘要： This invention provides compounds of formula I: wherein a, b, c, d, m, n, p, s, t, W, Ar1, R1, R2, R3, R4, R6, R7, and R8 are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.
摘要翻译： 本发明提供式I化合物：其中a，b，c，d，m，n，p，s，t，W，Ar1，R1，R2，R3，R4，R6，R7和R8如 规范。 式I化合物是毒蕈碱受体拮抗剂。 本发明还提供含有这些化合物的药物组合物，用于制备这些化合物的方法和中间体以及使用这些化合物治疗肺部疾病的方法。
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公开(公告)号：US20090018165A1
公开(公告)日：2009-01-15
申请号：US11879835
申请日：2007-07-19
申请人： Mathai Mammen , Yu-Hua Ji , YongQi Mu , Craig Husfeld , Li Li
发明人： Mathai Mammen , Yu-Hua Ji , YongQi Mu , Craig Husfeld , Li Li
IPC分类号： A61K31/4545 , C07D211/06 , A61P11/00 , A61P11/08
CPC分类号： C07D211/62 , A61K9/124 , A61K9/1623 , A61K9/1652 , A61K31/4545 , A61K45/06 , C07D401/12
摘要： This invention provides compounds of formula I: wherein a, b, c, d, m, n, p, s, t, W, Ar1, R1, R2, R3, R4, R6, R7, and R8 are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.
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公开(公告)号：US20080095708A1
公开(公告)日：2008-04-24
申请号：US11974318
申请日：2007-10-12
申请人： Mathai Mammen , Yu-Hua Ji , YongQi Mu , Craig Husfeld , Li Li
发明人： Mathai Mammen , Yu-Hua Ji , YongQi Mu , Craig Husfeld , Li Li
IPC分类号： A61K49/00 , A61K31/454 , G01N33/53 , A61K31/4545
CPC分类号： C07D211/62 , A61K9/124 , A61K9/1623 , A61K9/1652 , A61K31/4545 , A61K45/06 , C07D401/12
摘要： This invention provides compounds of formula I: wherein a, b, c, d, m, n, p, s, t, W, Ar1, R1, R2, R3, R4, R6, R7, and R8 are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.
摘要翻译： 本发明提供式I化合物：其中a，b，c，d，m，n，p，s，t，W，Ar 1，R 1，R R 2，R 3，R 4，R 6，R 7和/或R 4， R 8如本说明书中所定义。 式I化合物是毒蕈碱受体拮抗剂。 本发明还提供含有这些化合物的药物组合物，用于制备这些化合物的方法和中间体以及使用这些化合物治疗肺部疾病的方法。
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公开(公告)号：US20070293461A1
公开(公告)日：2007-12-20
申请号：US11879829
申请日：2007-07-19
申请人： Mathai Mammen , Yu-Hua Ji , Yong-Qi Mu , Eric Stangeland , Aaron Kushner , Craig Husfeld
发明人： Mathai Mammen , Yu-Hua Ji , Yong-Qi Mu , Eric Stangeland , Aaron Kushner , Craig Husfeld
IPC分类号： A61K31/56 , A61K31/45 , A61P11/08 , A61P9/00 , C07D211/06
CPC分类号： C07D211/62 , C07D211/60
摘要： This invention provides compounds of formula I: wherein a, b, c, d, m, n, p, r, R1, R2, R3, R4, R5, R6, R7, and W are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.
摘要翻译： 本发明提供式I化合物：其中a，b，c，d，m，n，p，r，R 1，R 2，R 3 R 4，R 5，R 5，R 6，R 7和W定义如上所述。 在规范中。 式I化合物是毒蕈碱受体拮抗剂。 本发明还提供含有这些化合物的药物组合物，用于制备这些化合物的方法和中间体以及使用这些化合物治疗肺部疾病的方法。
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