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40 条记录 (耗时 0.04 秒)

    N,N-dimethyldiatrizoic acid and its conjugates as hepatobiliary agents for X-ray CT imaging
    32.
    发明授权
    N,N-dimethyldiatrizoic acid and its conjugates as hepatobiliary agents for X-ray CT imaging 有权
    N，N-二甲基二异辛酸及其共轭物作为X线CT成像的肝胆药

    公开(公告)号：US6051210A

    公开(公告)日：2000-04-18

    申请号：US273522

    申请日：1999-03-22

    申请人： Rama S. Ranganathan ,  Thangavel Arunachalam ,  Michael F. Tweedle

    发明人： Rama S. Ranganathan ,  Thangavel Arunachalam ,  Michael F. Tweedle

    IPC分类号： A61K49/04 ,  A61B8/13

    CPC分类号： A61K49/0447 ,  A61K49/0438

    摘要： Compounds having formulae I, II or III, or pharmaceutically acceptable salts thereof, ##STR1## wherein ##STR2## R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7 and R.sub.8 are the same or different and are hydrogen, alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aralkyl, substituted or unsubstituted aryl, haloalkyl, hydroxyalkyl, alkoxyalkyl, carboxyalkyl or carboxamido alkyl with the proviso that in formula I R.sub.2 and R.sub.3 cannot be methyl; andm, n and p are the same or different and are 0-24 with the proviso that m+n.ltoreq.24, are useful as contrast agents in x-ray imaging compositions and methods.

    摘要翻译： 具有式I，II或III的化合物或其药学上可接受的盐，其中R1，R2，R3，R4，R5，R6，R7和R8相同或不同，为氢，烷基，取代或未取代的环烷基，取代或未取代的 芳烷基，取代或未取代的芳基，卤代烷基，羟基烷基，烷氧基烷基，羧基烷基或甲酰氨基烷基，条件是式I中R 2和R 3不能为甲基; 并且m，n和p相同或不同，并且0-24，条件是m + n = 24，可用作x射线成像组合物和方法中的造影剂。

    Dual functioning excipient for metal chelate contrast agents
    36.
    发明授权
    Dual functioning excipient for metal chelate contrast agents 失效
    金属螯合造影剂双功能赋形剂

    公开(公告)号：US07385041B2

    公开(公告)日：2008-06-10

    申请号：US10787526

    申请日：2004-02-26

    申请人： C. Allen Chang ,  Krishan Kumar ,  Michael F. Tweedle

    发明人： C. Allen Chang ,  Krishan Kumar ,  Michael F. Tweedle

    IPC分类号： C07F13/00

    CPC分类号： A61K49/06 ,  A61K49/0002 ,  A61K49/04 ,  A61K51/0482 ,  A61K2123/00

    摘要： A novel dual functioning excipient for metal chelate contrast agents is disclosed. The present excipient, Xm[X′(L′)]n, which is the calcium or zinc salt of the calcium or zinc complex of an organic ligand, enhances safety in that it is able to scavenge both free metal ions and free organic ligand.

    摘要翻译： 公开了一种用于金属螯合造影剂的新型双功能赋形剂。 本发明的赋形剂<？in-line-formula description =“In-line Formulas”end =“lead”？> X＆lt; X'（L'）] n ，<？in-line-formula description =“在线公式”end =“tail”？>它是有机配体的钙或锌络合物的钙或锌盐，增强了安全性，因为它能够 清除游离金属离子和游离有机配体。