公开(公告)号：US09580372B2

公开(公告)日：2017-02-28

申请号：US14455371

申请日：2014-08-08

Applicant: NEONC TECHNOLOGIES INC.

Inventor： Thomas Chen ,  Daniel Levin ,  Satish Pupalli

IPC: C07C33/14 ,  A61K31/415 ,  A61K45/06 ,  A61K47/48 ,  A61N5/10 ,  C07D207/26 ,  C07D231/12 ,  C07D487/04 ,  A61K31/495 ,  A61K31/4188 ,  A61K31/045 ,  A61K31/4015 ,  C07B59/00

CPC classification number: C07C33/14 ,  A61K9/0043 ,  A61K31/045 ,  A61K31/4015 ,  A61K31/415 ,  A61K31/4188 ,  A61K31/495 ,  A61K45/06 ,  A61K47/54 ,  A61K47/542 ,  A61K47/543 ,  A61N5/10 ,  C07B59/00 ,  C07B2200/05 ,  C07C2601/16 ,  C07D207/26 ,  C07D231/12 ,  C07D487/04

Abstract: The present invention provides for a derivative of monoterpene or sesquiterpene, such as a perillyl alcohol derivative. For example, the perillyl alcohol derivative may be a perillyl alcohol carbamate. The perillyl alcohol derivative may be perillyl alcohol conjugated with a therapeutic agent such as a chemotherapeutic agent. The present invention also provides for a method of treating a disease such as cancer, comprising the step of delivering to a patient a therapeutically effective amount of a derivative of monoterpene (or sesquiterpene). The route of administration may vary, and can include, inhalation, intranasal, oral, transdermal, intravenous, subcutaneous or intramuscular injection.

Abstract translation: 本发明提供单萜或倍半萜衍生物，例如芳香醇衍生物。 例如，紫苏醇衍生物可以是芳族醇氨基甲酸酯。 紫苏醇衍生物可以是与治疗剂如化学治疗剂缀合的紫苏醇。 本发明还提供了治疗诸如癌症的疾病的方法，其包括向患者递送治疗有效量的单萜（或倍半萜烯）衍生物的步骤。 给药途径可以变化，并且可以包括吸入，鼻内，口服，透皮，静脉内，皮下或肌内注射。