公开(公告)号：US20230248662A1

公开(公告)日：2023-08-10

申请号：US18190643

申请日：2023-03-27

Applicant: NeOnc Technologies, Inc.

Inventor： Thomas CHEN

IPC: A61K31/045 ,  A61P35/00 ,  A61K9/00 ,  A61K31/4015 ,  A61K31/415 ,  A61K31/4188 ,  A61K31/4745 ,  A61K35/17 ,  A61K39/395 ,  A61K45/06 ,  C07K14/705 ,  C07K16/42

CPC classification number: A61K31/045 ,  A61P35/00 ,  A61K9/0019 ,  A61K9/0043 ,  A61K9/0078 ,  A61K31/4015 ,  A61K31/415 ,  A61K31/4188 ,  A61K31/4745 ,  A61K35/17 ,  A61K39/3955 ,  A61K45/06 ,  C07K14/70503 ,  C07K16/42 ,  A61K2039/505

Abstract: The present invention relates to using monoterpene or sesquiterpene to permeabilize the blood brain barrier.

公开(公告)号：US20230212571A1

公开(公告)日：2023-07-06

申请号：US18001082

申请日：2021-06-08

Applicant: NeOnc Technologies, Inc.

Inventor： Thomas C. CHEN

IPC: C12N15/113 ,  A61P7/00

CPC classification number: C12N15/113 ,  A61P7/00 ,  C12N2310/141

Abstract: The disclosure relates to compositions, methods, and kits for using perillyl alcohol and/or an Argonaute protein (e.g., Ago-2) to deliver a polynucleotide to a cell. The disclosure also relates to compositions, methods, and kits for treating a condition by using perillyl alcohol and/or an Argonaute protein (e.g., Ago-2) to deliver a polynucleotide to a cell. The conditions may be brain vascular diseases and brain tumors.

公开(公告)号：US20220378780A1

公开(公告)日：2022-12-01

申请号：US17762878

申请日：2020-09-23

Applicant: NeOnc Technologies, Inc.

Inventor： Thomas CHEN ,  Axel SCHÖNTHAL

IPC: A61K31/495 ,  A61K31/415 ,  A61K31/4015 ,  A61K47/54 ,  A61P35/02

Abstract: The present invention provides for a derivative of monoterpene or sesquiterpene, such as a perillyl alcohol derivative. For example, the perillyl alcohol derivative may be a perillyl alcohol carbamate. The perillyl alcohol derivative may be perillyl alcohol conjugated with a therapeutic agent such as a chemotherapeutic agent. The present invention also provides for a method of treating a disease such as a primary cutaneous lymphoma which may be a cutaneous T cell lymphoma (CTCL). The CTCL may be mycosis fungoides, primary cutaneous anaplastic large cell lymphoma (ALCL), or Sezary syndrome. A patient may be administered a therapeutically effective amount of a derivative of monoterpene (or sesquiterpene).

公开(公告)号：US20220096464A1

公开(公告)日：2022-03-31

申请号：US17390292

申请日：2021-07-30

Applicant: NeOnc Technologies, Inc.

Inventor： Thomas CHEN

IPC: A61K31/495 ,  A61K47/55 ,  A61K47/54

Abstract: A method for treating brain metastases of a cancer in a mammal includes administering to the mammal a therapeutically effective amount of a perillyl alcohol carbamate, such as TMZ-POH. The brain metastases can be originated or spread from breast cancer. The perillyl alcohol derivative may be perillyl alcohol conjugated with a therapeutic agent, such as a chemotherapeutic agent. The chemotherapeutic agents that may be used in the present invention include a DNA alkylating agent, a topoisomerase inhibitor, an endoplasmic reticulum stress inducing agent, a platinum compound, an antimetabolite, an enzyme inhibitor, and a receptor antagonist.

公开(公告)号：US11077104B2

公开(公告)日：2021-08-03

申请号：US16123729

申请日：2018-09-06

Applicant: NeOnc Technologies, Inc.

Inventor： Thomas Chen ,  Daniel Levin ,  Satish Pupalli

IPC: A61K31/495 ,  A61K31/415 ,  A61K47/54 ,  A61K45/06 ,  A61N5/10 ,  C07D207/26 ,  C07D231/12 ,  C07D487/04 ,  A61K31/4188 ,  A61K31/045 ,  A61K31/4015 ,  C07B59/00 ,  C07C33/14 ,  A61K9/00

Abstract: The present invention provides for a derivative of monoterpene or sesquiterpene, such as a perillyl alcohol derivative. For example, the perillyl alcohol derivative may be a perillyl alcohol carbamate. The perillyl alcohol derivative may be perillyl alcohol conjugated with a therapeutic agent such as a chemotherapeutic agent. The present invention also provides for a method of treating a disease such as cancer, comprising the step of delivering to a patient a therapeutically effective amount of a derivative of monoterpene (or sesquiterpene). The route of administration may vary, and can include, inhalation, intranasal, oral, transdermal, intravenous, subcutaneous or intramuscular injection.

公开(公告)号：US20210228498A1

公开(公告)日：2021-07-29

申请号：US16967549

申请日：2019-02-07

Applicant: NeOnc Technologies, Inc.

Inventor： Thomas CHEN

IPC: A61K31/045 ,  C07K14/705 ,  C07K16/42 ,  A61P35/00 ,  A61K39/395 ,  A61K9/00 ,  A61K31/415 ,  A61K31/4745 ,  A61K31/4188 ,  A61K31/4015 ,  A61K45/06 ,  A61K35/17

Abstract: The present invention relates to using monoterpene or sesquiterpene to permeabilize the blood brain barrier.

公开(公告)号：US09987271B2

公开(公告)日：2018-06-05

申请号：US15429556

申请日：2017-02-10

Applicant: NeOnc Technologies, Inc.

Inventor： Thomas Chen

IPC: A61K31/495 ,  A61K45/06 ,  A61K9/00 ,  A61M15/00 ,  A61M15/08 ,  A61K47/54

CPC classification number: A61K31/495 ,  A61K9/0019 ,  A61K9/0043 ,  A61K9/0073 ,  A61K45/06 ,  A61K47/542 ,  A61M15/009 ,  A61M15/08

Abstract: A method of treating nasopharyngeal carcinoma in a mammal includes delivering to the mammal a therapeutically effective amount of a perillyl alcohol (POH) carbamate which is a perillyl alcohol conjugated with temozolomide (TMZ).

公开(公告)号：US09700524B2

公开(公告)日：2017-07-11

申请号：US15040002

申请日：2016-02-10

Applicant: NEONC Technologies, Inc.

Inventor： Thomas Chen ,  Daniel Levin ,  Satish Puppali

IPC: A61K31/045 ,  C07C29/92 ,  C07C67/14 ,  C07C201/12 ,  C07C29/78 ,  C07C29/88 ,  C07C201/16 ,  A61K31/4188 ,  A61K45/06 ,  A61N5/10

CPC classification number: C07C29/92 ,  A61K31/045 ,  A61K31/4188 ,  A61K45/06 ,  A61N5/10 ,  C07B2200/07 ,  C07C29/78 ,  C07C29/86 ,  C07C29/88 ,  C07C67/14 ,  C07C201/12 ,  C07C201/16 ,  C07C2601/16 ,  C07C33/14 ,  C07C205/57 ,  C07C69/76 ,  C07C69/92

Abstract: The present invention provides a process for purifying a monoterpene or sesquiterpene having a purity greater than about 98.5% (w/w). The process comprises the steps of derivatizing the monoterpene (or sesquiterpene) to produce a monoterpene (or sesquiterpene) derivative, separating the monoterpene (or sesquiterpene) derivative, and releasing the monoterpene (or sesquiterpene) from the derivative. Also encompassed by the scope of the present invention is a pharmaceutical composition comprising a monoterpene (or sesquiterpene) having a purity greater than about 98.5% (w/w). The purified monoterpene can be used to treat a disease such as cancer. The present monoterpene (or sesquiterpene) may be administered alone, or may be co-administered with radiation or other therapeutic agents, such as chemotherapeutic agents.

公开(公告)号：US09657026B2

公开(公告)日：2017-05-23

申请号：US15192126

申请日：2016-06-24

Applicant: NEONC TECHNOLOGIES INC.

Inventor： Thomas Chen ,  Daniel Levin ,  Satish Pupalli

IPC: C07D487/04 ,  C07D231/12

CPC classification number: C07D487/04 ,  C07D231/12

Abstract: A pharmaceutical composition is provided which includes perillyl alcohol conjugated with a therapeutic agent and further includes and a hydrolyzable acylated aliphatic tail. A method of using the pharmaceutical composition is also provided for treating a condition or disease of a patient, e.g., cancer.

公开(公告)号：US20160039731A1

公开(公告)日：2016-02-11

申请号：US14359366

申请日：2012-11-21

Applicant: NEONC TECHNOLOGIES INC.

Inventor： Thomas Chen ,  Daniel Levin ,  Satish Pupalli

IPC: C07C33/14 ,  A61K31/4188 ,  A61K31/4015 ,  A61N5/10 ,  A61K31/415 ,  A61K45/06 ,  C07B59/00 ,  A61K47/48 ,  A61K31/045

CPC classification number: A61K31/495 ,  A61K9/0043 ,  A61K31/045 ,  A61K31/4015 ,  A61K31/415 ,  A61K31/4188 ,  A61K45/06 ,  A61K47/54 ,  A61K47/542 ,  A61K47/543 ,  A61N5/10 ,  C07B59/00 ,  C07B2200/05 ,  C07C33/14 ,  C07C2601/16 ,  C07D207/26 ,  C07D231/12 ,  C07D487/04

Abstract: The present invention, provides for a deuterium-enriched monoterpene or sesquiterpene such as perillyl alcohol, or a deuterium-enriched isomer or analog of monoterpenes or sesquiterpenes, such as isoperillyl alcohol. The present invention also provides for a deuterium-enriched derivative of a monoterpene or sesquiterpene, such as a perillyl alcohol carbamate or a deuterium-enriched derivative of an isomer or analog of a monoterpene or sesquiterpene, such as an isoperillyl alcohol carbamate. The deuterium-enriched derivative may be perillyl alcohol or isoperillyl alcohol conjugated with a therapeutic agent such as a chemotherapeutic agent. The present invention also provides for a method of treating a disease such as cancer, comprising the step of delivering to a patient a therapeutically effective amount of a deuterium-enriched compound.

Abstract translation: 本发明提供富含氘的单萜或倍半萜如香叶醇，或氘富含异构体或单萜或倍半萜类似物，如异戊醇。 本发明还提供了单萜或倍半萜的富氘代衍生物，如苝基氨基甲酸酯或单萜或倍半萜的异构体或类似物的氘富集衍生物，例如异戊醇醇氨基甲酸酯。 富含氘的衍生物可以是与诸如化学治疗剂的治疗剂缀合的紫苏醇或异环戊醇。 本发明还提供了治疗诸如癌症的疾病的方法，其包括向患者递送治疗有效量的富含氘化合物的步骤。