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公开(公告)号：US20150157734A1
公开(公告)日：2015-06-11
申请号：US14627370
申请日：2015-02-20
申请人： NEKTAR THERAPEUTICS
IPC分类号： A61K47/48 , A61K31/353
CPC分类号： A61K47/48215 , A61K31/353 , A61K47/60
摘要： The invention provides oligomer-bis-chromonyl compound conjugates. The conjugates of the invention, when administered by any of a number of administration routes, exhibits advantages over previously administered compounds.
摘要翻译： 本发明提供低聚物 - 双 - 色酮化合物共轭物。 当通过任何多种施用途径施用时，本发明的缀合物显示出优于先前给予的化合物的优点。
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公开(公告)号：US20150065706A1
公开(公告)日：2015-03-05
申请号：US14528444
申请日：2014-10-30
申请人： NEKTAR THERAPEUTICS
IPC分类号： C07D253/075
CPC分类号： C07D253/075 , A61K31/53 , A61K47/60
摘要： The invention relates to (among other things) methods for treatment comprising administering oligomer-containing substituted aromatic triazine compounds. A compound of the invention, when administered by any of a number of administration routes, exhibits one or more advantages over corresponding compounds lacking the oligomer.
摘要翻译： 本发明涉及（尤其是）治疗方法，包括施用含低聚物的取代的芳族三嗪化合物。 当通过任何多种施用途径给药时，本发明的化合物显示出相对于缺乏寡聚物的相应化合物的一个或多个优点。
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公开(公告)号：US08952032B2
公开(公告)日：2015-02-10
申请号：US14032648
申请日：2013-09-20
申请人： Nektar Therapeutics
IPC分类号： A61K31/485 , C07D489/04 , A61K47/48 , A61K31/439 , C07D489/02
CPC分类号： A61K31/485 , A61K31/402 , A61K31/4025 , A61K31/439 , A61K31/4468 , A61K47/10 , A61K47/60 , C07D489/02
摘要： The invention provides compounds that are chemically modified by covalent attachment of a water-soluble oligomer. A compound of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from those of the compound not attached to the water-soluble oligomer.
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公开(公告)号：US20140329895A1
公开(公告)日：2014-11-06
申请号：US14338111
申请日：2014-07-22
申请人： NEKTAR THERAPEUTICS
IPC分类号： A61K47/48
CPC分类号： A61K47/48215 , A61K47/60 , C07D311/78
摘要： The invention relates to (among other things) oligomer-cannabinoid conjugates and related compounds. A conjugate of the invention, when administered by any of a number of administration routes, exhibits advantages over previously administered un-conjugated cannabinoid compounds.
摘要翻译： 本发明涉及（尤其是）低聚物 - 大麻素结合物和相关化合物。 当通过任何多种施用途径给药时，本发明的缀合物显示出优于先前给予的未共轭大麻素化合物的优点。
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公开(公告)号：US20140329828A1
公开(公告)日：2014-11-06
申请号：US14336764
申请日：2014-07-21
申请人： Nektar Therapeutics
发明人： Jennifer Riggs-Sauthier , Wen Zhang
IPC分类号： A61K47/48
CPC分类号： A61K47/48215 , A61K31/541 , A61K47/60 , C07D417/14
摘要： The invention relates to (among other things) oligomer-PTK inhibitor conjugates and related compounds. A compound of the invention, when administered by any of a number of administration routes, exhibits advantages over PTK inhibitor compounds lacking a water-soluble, non-peptidic oligomer.
摘要翻译： 本发明涉及（尤其是）低聚物-PTK抑制剂缀合物和相关化合物。 当通过任何一种施用途径给药时，本发明的化合物显示出优于缺乏水溶性非肽寡聚物的PTK抑制剂化合物的优点。
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公开(公告)号：US20140323529A1
公开(公告)日：2014-10-30
申请号：US14266317
申请日：2014-04-30
申请人： NEKTAR THERAPEUTICS
IPC分类号： A61K47/48 , A61K31/4418
CPC分类号： A61K31/4422 , A61K31/4418 , A61K47/48215 , A61K47/60 , C07C255/43 , C07D211/90 , C07D281/10 , C07D413/04 , C07D417/04
摘要： The invention provides small molecule drugs that are chemically modified by covalent attachment of a water soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of the small molecule drug not attached to the water soluble oligomer.
摘要翻译： 本发明提供通过共价连接水溶性低聚物进行化学修饰的小分子药物。 本发明的缀合物当通过多种施用途径中的任一种施用时，显示出与未附着于水溶性低聚物的小分子药物的特征不同的特征。
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公开(公告)号：US20140113961A1
公开(公告)日：2014-04-24
申请号：US14137090
申请日：2013-12-20
申请人： NEKTAR THERAPEUTICS
IPC分类号： A61K47/48
CPC分类号： A61K31/337 , A61K31/4745 , A61K31/785 , A61K38/00 , A61K47/60 , C08G65/3328 , C08G65/33344 , C08G79/08
摘要： Among other aspects, provided herein are multi-armed polymer conjugates comprising an alkanoate-linker, compositions comprising such conjugates, and related methods of making and administering the same. Methods of treatment employing such conjugates and related uses are also provided. The conjugates are prepared with high drug loading efficiencies.
摘要翻译： 在其它方面，本文提供了包含链烷酸酯 - 连接体，包含这种缀合物的组合物的多臂聚合物缀合物及其制备和施用相关方法。 还提供了使用这种缀合物和相关用途的治疗方法。 以高药物负载效率制备缀合物。
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公开(公告)号：US11612662B2
公开(公告)日：2023-03-28
申请号：US16912065
申请日：2020-06-25
申请人： Nektar Therapeutics
发明人： Lin Cheng , Jennifer Riggs-Sauthier
IPC分类号： A61K47/60
摘要： Among other aspects, provided herein are multi-arm polymeric prodrug conjugates of pemetrexed-based compounds. Methods of preparing such conjugates as well as methods of administering the conjugates are also provided. Upon administration to a patient, release of the pemetrexed-based compound is achieved.
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公开(公告)号：US20200030451A1
公开(公告)日：2020-01-30
申请号：US16592702
申请日：2019-10-03
申请人： Nektar Therapeutics
摘要： The invention relates to (among other things) polymer-semaxanib moiety conjugates and related compounds. A compound of the invention, when administered by any of a number of administration routes, exhibits advantages over the semaxanib moiety in unconjugated form.
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公开(公告)号：US20180185499A1
公开(公告)日：2018-07-05
申请号：US15908286
申请日：2018-02-28
申请人： Nektar Therapeutics
IPC分类号： A61K47/59 , C07C237/44 , A61K31/166 , C07C231/12
CPC分类号： A61K47/59 , A61K31/166 , A61K47/60 , C07C231/12 , C07C237/44
摘要： The invention relates to (among other things) oligomer-containing benzamide-based compound compounds. A compound of the invention exhibits one or more advantages over corresponding compounds lacking the oligomer.
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