公开(公告)号：US20100068283A1

公开(公告)日：2010-03-18

申请号：US12387312

申请日：2009-04-29

申请人： Mahalaxmi Gita Bangera ,  Edward S. Boyden ,  Roderick A. Hyde ,  Muriel Y. Ishikawa ,  Dennis J. Rivet ,  Elizabeth A. Sweeney ,  Lowell L. Wood, JR. ,  Victoria Y.H. Wood

发明人： Mahalaxmi Gita Bangera ,  Edward S. Boyden ,  Roderick A. Hyde ,  Muriel Y. Ishikawa ,  Dennis J. Rivet ,  Elizabeth A. Sweeney ,  Lowell L. Wood, JR. ,  Victoria Y.H. Wood

IPC分类号： A61K9/14

CPC分类号： G06F19/3456 ,  A61K9/06 ,  A61K9/127 ,  A61K9/4891 ,  A61K9/51

摘要： Described embodiments include a final dosage form, an article of manufacture, and method. A final dosage form for administering a medicament to an animal is described. The final dosage form includes the medicament. The final dosage form also includes a particle or polymeric material carrying the medicament in a first medicament-release state wherein the medicament is available to the animal in a first bioavailability if the final dosage form is administered to the animal. The particle or polymeric material is modifiable ex vivo by an exposure to a stimulus to carry the medicament in a second medicament-release state wherein the medicament is available to the animal in a second bioavailability if the final dosage form is administered to the animal. In an embodiment, the final dosage form further includes a transport medium suitable for delivering the particle or polymeric material binding the medicament to the animal.

摘要翻译： 描述的实施方案包括最终剂型，制品和方法。 描述了向动物施用药物的最终剂型。 最终剂型包括药物。 最终剂型还包括在第一药物释放状态下携带药物的颗粒或聚合物质，其中如果向动物施用最终剂型，则药物可以以第一生物利用度获得。 颗粒或聚合物材料可以通过暴露于刺激物来离体修饰，以在第二药物释放状态下携带药物，其中如果向动物施用最终剂型，则药物可以以第二生物利用度获得。 在一个实施方案中，最终剂型还包括适于将结合药物的颗粒或聚合物质输送到动物的转运介质。

公开(公告)号：US20100069822A1

公开(公告)日：2010-03-18

申请号：US12387329

申请日：2009-04-29

申请人： Mahalaxmi Gita Bangera ,  Edward S. Boyden ,  Roderick A. Hyde ,  Muriel Y. Ishikawa ,  Dennis J. Rivet ,  Elizabeth A. Sweeney ,  Lowell L. Wood, JR. ,  Victoria Y.H. Wood

发明人： Mahalaxmi Gita Bangera ,  Edward S. Boyden ,  Roderick A. Hyde ,  Muriel Y. Ishikawa ,  Dennis J. Rivet ,  Elizabeth A. Sweeney ,  Lowell L. Wood, JR. ,  Victoria Y.H. Wood

IPC分类号： A61N1/30 ,  A61N5/00 ,  A61N7/00

CPC分类号： A61K9/28 ,  A61K9/0009 ,  G06F19/3462

摘要： Described embodiments include a system. A described system includes a computer-readable storage medium configured to indicate a stimulus to modify ex vivo a bioavailability of a medicament carried by a final dosage form based upon a selected medicament bioavailability of the final dosage form. The system also includes a holder configured to establish ex vivo of the animal a location of the final dosage form to receive the indicated stimulus from a stimulus source. The system further includes the stimulus source operable to provide the indicated stimulus. The system also includes a stimulation controller operable to regulate an ex vivo exposure of the final dosage form to the indicated stimulus.

摘要翻译： 描述的实施例包括系统。 所描述的系统包括计算机可读存储介质，其被配置为基于所选择的最终剂型的药物生物利用度来指示刺激以离体修饰由最终剂型携带的药物的生物利用度。 该系统还包括保持器，其被配置为建立动物离体的最终剂型的位置以从刺激源接收指示的刺激。 该系统还包括可操作以提供所指示的刺激的刺激源。 该系统还包括刺激控制器，该刺激控制器可操作以调节最终剂型对所述刺激物的离体暴露。

公开(公告)号：US20100068256A1

公开(公告)日：2010-03-18

申请号：US12387311

申请日：2009-04-29

申请人： Mahalaxmi Gita Bangera ,  Edward S. Boyden ,  Roderick A. Hyde ,  Muriel Y. Ishikawa ,  Dennis J. Rivet ,  Elizabeth A. Sweeney ,  Lowell L. Wood, JR. ,  Victoria Y.H. Wood

发明人： Mahalaxmi Gita Bangera ,  Edward S. Boyden ,  Roderick A. Hyde ,  Muriel Y. Ishikawa ,  Dennis J. Rivet ,  Elizabeth A. Sweeney ,  Lowell L. Wood, JR. ,  Victoria Y.H. Wood

IPC分类号： A61K9/127 ,  A61K9/10

CPC分类号： G06F19/3456 ,  A61K9/06 ,  A61K9/127 ,  A61K9/4891 ,  A61K9/51

摘要： A described final dosage form includes a substance carrying a medicament in a first medicament-release state having a first bioavailability. The substance is modifiable ex vivo by an exposure to a first stimulus to carry the medicament in a second medicament-release state having a second bioavailability. The substance is modifiable ex vivo by an exposure to a second stimulus to carry the medicament in a third medicament-release state having a third bioavailability. The final dosage form includes another substance carrying another medicament in another first medicament-release state having another first bioavailability. The another substance is modifiable ex vivo by an exposure to another first stimulus to carry the another medicament in another second medicament-release state having another second bioavailability. The another substance is modifiable ex vivo by an exposure to another second stimulus to carry the another medicament in another third medicament-release state having another third bioavailability.

摘要翻译： 所描述的最终剂型包括携带具有第一生物利用度的第一药物释放状态的药物的物质。 该物质可以通过暴露于第一次刺激而离体修饰，以使药物在具有第二生物利用度的第二药物释放状态下携带。 该物质可通过暴露于第二刺激物离体修饰以携带具有第三生物利用度的第三药物释放状态的药物。 最终剂型包括在另一第一药物释放状态下携带具有另一第一生物利用度的另一药物的另一物质。 另一种物质可以通过暴露于另一种第一刺激离体来修饰，以携带具有另一第二生物利用度的另一第二药物释放状态的另一种药物。 通过暴露于另一第二刺激物，另一种物质可以通过暴露于另一种第二刺激来进行修饰，从而将另一种药物置于具有另一种第三生物利用度的另一种第三药物释

公开(公告)号：US20100068233A1

公开(公告)日：2010-03-18

申请号：US12284013

申请日：2008-09-16

申请人： Mahalaxmi Gita Bangera ,  Edward S. Boyden ,  Roderick A. Hyde ,  Muriel Y. Ishikawa ,  Dennis J. Rivet ,  Elizabeth A. Sweeney ,  Lowell L. Wood, JR. ,  Victoria Y.H. Wood

发明人： Mahalaxmi Gita Bangera ,  Edward S. Boyden ,  Roderick A. Hyde ,  Muriel Y. Ishikawa ,  Dennis J. Rivet ,  Elizabeth A. Sweeney ,  Lowell L. Wood, JR. ,  Victoria Y.H. Wood

IPC分类号： A61K9/127 ,  A61K9/00 ,  A61K9/24 ,  A61K9/52 ,  A61K9/14 ,  A61K9/10

CPC分类号： A61K9/0009 ,  A61K9/28

摘要： Provided embodiments include a final dosage form, an article of manufacture, and method. A final dosage form for delivering a medicament to an animal is provided. The final dosage form includes an outer layer. The final dosage form also includes a release element configured in a first medicament-release state and modifiable to a second medicament-release state upon an ex vivo exposure to a stimulus. The final dosage form further includes a chamber at least substantially within the outer layer and configured to carry the medicament. The final dosage form includes the medicament. The final dosage form may include an indicator element configured to indicate an exposure of the release element to the stimulus.

摘要翻译： 提供的实施方案包括最终剂型，制品和方法。 提供了用于将药物递送至动物的最终剂型。 最终的剂型包括外层。 最终剂型还包括配置在第一药物释放状态中的释放元件，并且在体外暴露于刺激物时可修改为第二药物释放状态。 最终剂型还包括至少基本上在外层内并且构造成携带药物的腔室。 最终剂型包括药物。 最终剂型可以包括指示元件，其被配置为指示释放元件暴露于刺激。

公开(公告)号：US20100068153A1

公开(公告)日：2010-03-18

申请号：US12322878

申请日：2009-02-05

申请人： Mahalaxmi Gita Bangera ,  Edward S. Boyden ,  Roderick A. Hyde ,  Muriel Y. Ishikawa ,  Dennis J. Rivet ,  Elizabeth A. Sweeney ,  Lowell L. Wood, JR. ,  Victoria Y.H. Wood

发明人： Mahalaxmi Gita Bangera ,  Edward S. Boyden ,  Roderick A. Hyde ,  Muriel Y. Ishikawa ,  Dennis J. Rivet ,  Elizabeth A. Sweeney ,  Lowell L. Wood, JR. ,  Victoria Y.H. Wood

IPC分类号： A61K49/00 ,  A61K9/00 ,  A61K9/14

CPC分类号： A61K9/0009 ,  A61K9/2086 ,  A61K9/2886 ,  A61K41/0028

摘要： Provided embodiments include a final dosage form, an article of manufacture, and method. A final dosage form for administering a medicament to an animal is provided. The final dosage form includes an outer layer, the medicament, and a release element. The release element configured in a medicament-holding state and modifiable ex vivo to a medicament-discharge state by an exposure to a stimulus. In an embodiment, the final dosage form includes a chamber substantially within the outer layer and carrying the medicament. In an embodiment, the final dosage form includes an indicator element configured to indicate an exposure of the release element to the stimulus.

摘要翻译： 提供的实施方案包括最终剂型，制品和方法。 提供了用于向动物施用药物的最终剂型。 最终剂型包括外层，药物和释放元件。 所述释放元件构造成药物保持状态，并且通过暴露于刺激物离体修改为药物 - 放电状态。 在一个实施方案中，最终剂型包括基本上在外层内并承载药物的室。 在一个实施方案中，最终剂型包括指示元件，其被配置为指示释放元件暴露于刺激物。

公开(公告)号：US20090086905A1

公开(公告)日：2009-04-02

申请号：US11906161

申请日：2007-09-28

申请人： Edward S. Boyden ,  Roderick A. Hyde ,  Muriel Y. Ishikawa ,  Edward K.Y. Jung ,  Eric C. Leuthardt ,  Robert W. Lord ,  Nathan P. Myhrvold ,  Dennis J. Rivet ,  Michael A. Smith ,  Clarence T. Tegreene ,  Thomas A. Weaver ,  Charles Whitmer ,  Lowell L. Wood, JR. ,  Victoria Y.H. Wood

发明人： Edward S. Boyden ,  Roderick A. Hyde ,  Muriel Y. Ishikawa ,  Edward K.Y. Jung ,  Eric C. Leuthardt ,  Robert W. Lord ,  Nathan P. Myhrvold ,  Dennis J. Rivet ,  Michael A. Smith ,  Clarence T. Tegreene ,  Thomas A. Weaver ,  Charles Whitmer ,  Lowell L. Wood, JR. ,  Victoria Y.H. Wood

IPC分类号： G01N23/223

CPC分类号： G01N23/223 ,  G01N2223/076

摘要： One aspect relates to inducing at least one induced X-ray fluorescing photon within an at least some matter of an at least a portion of an at least one individual responsive to a substantial single input energy event based at least partially on an at least some input energy being applied to the at least some matter of the at least the portion of the at least one individual; and detecting the at least one induced X-ray fluorescing photon; and X-ray fluorescence visualizing, imaging, or information providing within the at least some matter of the at least the portion of the at least one individual responsive to the detecting the at least one induced X-ray fluorescing photon.

摘要翻译： 一个方面涉及至少部分地基于至少一些输入而在至少一个个体的至少一部分的至少一些物质内诱导至少一个诱导的X射线荧光光子，所述至少一个个体响应于基本的单个输入能量事件 能量被施加到至少一个个体的至少一部分的至少一些物质; 以及检测所述至少一个诱导的X射线荧光光子; 以及响应于检测所述至少一个诱导的X射线荧光光子，在所述至少一个个体的至少一部分的至少一些物质内提供X射线荧光可视化，成像或信息。

公开(公告)号：US20090086899A1

公开(公告)日：2009-04-02

申请号：US11906096

申请日：2007-09-28

申请人： Edward S. Boyden ,  Roderick A. Hyde ,  Muriel Y. Ishikawa ,  Edward K.Y. Jung ,  Eric C. Leuthardt ,  Robert W. Lord ,  Nathan P. Myhrvold ,  Dennis J. Rivet ,  Michael A. Smith ,  Clarence T. Tegreene ,  Thomas A. Weaver ,  Charles Whitmer ,  Lowell L. Wood, JR. ,  Victoria Y.H. Wood

发明人： Edward S. Boyden ,  Roderick A. Hyde ,  Muriel Y. Ishikawa ,  Edward K.Y. Jung ,  Eric C. Leuthardt ,  Robert W. Lord ,  Nathan P. Myhrvold ,  Dennis J. Rivet ,  Michael A. Smith ,  Clarence T. Tegreene ,  Thomas A. Weaver ,  Charles Whitmer ,  Lowell L. Wood, JR. ,  Victoria Y.H. Wood

IPC分类号： G01B15/02

CPC分类号： G01N23/223 ,  A61B5/445 ,  A61B6/12 ,  A61B6/483 ,  A61B6/485 ,  A61B6/488 ,  A61B6/503 ,  A61B6/504 ,  A61B6/505 ,  A61B6/506 ,  A61B6/507 ,  A61B6/508 ,  G01N2223/076

摘要： One aspect can relate to performing a first X-ray fluorescence visualizing, imaging, or information providing within a first field of view in an at least some matter of an at least a portion of an at least one individual based on at least one induced fluorescing X-ray photon. The aspect can include operationally repositioning the first X-ray fluorescence visualizing, imaging, or information providing to X-ray fluorescence visualize, image, or information provide from within the first field of view to within a second field of view. The aspect can include performing a second X-ray fluorescence visualizing, imaging, or information providing within the second field of view within the at least some matter of the at least the portion of the at least one individual.

摘要翻译： 一个方面可以涉及在至少一个个体的至少一部分的至少一些物质中，基于至少一种诱导的荧光发射来执行在第一视野内提供第一X射线荧光可视化，成像或信息 X射线光子。 该方面可以包括将第一X射线荧光可视化，成像或提供给第一视野内的X射线荧光可视化，图像或信息的信息重新定位到第二视场内。 该方面可以包括在至少一个个体的至少一部分的至少一些事项内执行第二视场内的第二X射线荧光可视化，成像或提供信息。

公开(公告)号：US20090086900A1

公开(公告)日：2009-04-02

申请号：US11906144

申请日：2007-09-28

申请人： Edward S. Boyden ,  Glenn B. Foster ,  Roderick A. Hyde ,  Muriel Y. Ishikawa ,  Edward K.Y. Jung ,  Eric C. Leuthardt ,  Robert W. Lord ,  Nathan P. Myhrvold ,  Dennis J. Rivet ,  Michael A. Smith ,  Clarence T. Tegreene ,  Thomas A. Weaver ,  Charles Whitmer ,  Lowell L. Wood, JR. ,  Victoria Y.H. Wood

发明人： Edward S. Boyden ,  Glenn B. Foster ,  Roderick A. Hyde ,  Muriel Y. Ishikawa ,  Edward K.Y. Jung ,  Eric C. Leuthardt ,  Robert W. Lord ,  Nathan P. Myhrvold ,  Dennis J. Rivet ,  Michael A. Smith ,  Clarence T. Tegreene ,  Thomas A. Weaver ,  Charles Whitmer ,  Lowell L. Wood, JR. ,  Victoria Y.H. Wood

IPC分类号： G01N23/223 ,  G01N23/225

CPC分类号： G01N23/223 ,  G01N2223/076

摘要： One aspect relates to inducing at least one induced X-ray fluorescing photon at a X-ray fluorescence event within an at least some matter of an at least a portion of an at least one individual responsive to an at least some input energy being applied to the at least some matter of the at least the portion of the at least one individual. The aspect can include detecting the at least one induced X-ray fluorescing photon, wherein the inducing at least one induced X-ray fluorescing photon and the detecting the at least one induced X-ray fluorescing photon is configured to be transported portably as a self-contained and self-powered unit.

摘要翻译： 一个方面涉及在至少一个个体的至少一部分的至少一部分内的X射线荧光事件处诱导至少一个诱导的X射线荧光光子，所述至少一个个体响应至少一些输入能量被施加到 所述至少一个个体的至少一部分的至少一些物质。 该方面可以包括检测至少一个诱导的X射线荧光光子，其中诱导至少一个诱导的X射线荧光光子和检测该至少一个诱导的X射线荧光光子被配置为作为自身便携式传送 包含和自供电单元。

公开(公告)号：US20120157829A1

公开(公告)日：2012-06-21

申请号：US12011983

申请日：2008-01-29

申请人： Edward S. Boyden ,  Glenn B. Foster ,  Roderick A. Hyde ,  Muriel Y. Ishikawa ,  Edward K.Y. Jung ,  Eric C. Leuthardt ,  Robert W. Lord ,  Nathan P. Myhrvold ,  Dennis J. Rivet ,  Michael A. Smith ,  Clarence T. Tegreene ,  Thomas A. Weaver ,  Charles Whitmer ,  Lowell L. Wood, JR. ,  Victoria Y.H. Wood

发明人： Edward S. Boyden ,  Glenn B. Foster ,  Roderick A. Hyde ,  Muriel Y. Ishikawa ,  Edward K.Y. Jung ,  Eric C. Leuthardt ,  Robert W. Lord ,  Nathan P. Myhrvold ,  Dennis J. Rivet ,  Michael A. Smith ,  Clarence T. Tegreene ,  Thomas A. Weaver ,  Charles Whitmer ,  Lowell L. Wood, JR. ,  Victoria Y.H. Wood

IPC分类号： A61B5/05 ,  G01N23/201

CPC分类号： A61B6/145 ,  A61B6/12 ,  A61B6/4021 ,  A61B6/461 ,  A61B6/482 ,  A61B6/483 ,  A61B6/505 ,  A61B18/12 ,  A61B18/20 ,  A61N7/02 ,  A61N2005/1054 ,  A61N2005/1061

摘要： Certain aspects relatee to ablating at least some matter of an at least a portion of an individual within an at least one prescribed desired ablating region at least partially responsive to a locating the at least one prescribed desired ablating region within the at least some matter of the at least the portion of the individual at least partially based on a material density of at least some of the at least some matter of the at least the portion of the individual. Certain aspects relatee to locating an at least one prescribed desired ablating region within the at least some matter of the at least the portion of the individual at least partially responsive to the Compton X-ray scattering visualizing, imaging, or information providing within the at least some matter of the at least the portion of the individual

摘要翻译： 某些方面涉及在至少一个规定的期望的烧蚀区域内至少消除个体的至少一部分的至少一些物质，至少部分地响应于在至少一个规定的期望的烧蚀区域的至少一些物质内定位至少一个规定的期望的烧蚀区域 至少部分个体至少部分地基于个体至少部分的至少一些物质的至少一些的材料密度。 某些方面涉及将至少一个规定的期望的烧蚀区域定位在个体的至少一部分内的至少一些物质中，至少部分地响应于康普顿X射线散射可视化，成像或至少在该至少 至少部分个人的一些事情

公开(公告)号：US20120014581A1

公开(公告)日：2012-01-19

申请号：US13199546

申请日：2011-08-31

申请人： Edward S. Boyden ,  Roderick A. Hyde ,  Muriel Y. Ishikawa ,  Edward K.Y. Jung ,  Eric C. Leuthardt ,  Nathan P. Myhrvold ,  Dennis J. Rivet ,  Michael A. Smith ,  Clarence T. Tegreene ,  Thomas A. Weaver ,  Charles Whitmer ,  Lowell L. Wood, JR. ,  Victoria Y.H. Wood

发明人： Edward S. Boyden ,  Roderick A. Hyde ,  Muriel Y. Ishikawa ,  Edward K.Y. Jung ,  Eric C. Leuthardt ,  Nathan P. Myhrvold ,  Dennis J. Rivet ,  Michael A. Smith ,  Clarence T. Tegreene ,  Thomas A. Weaver ,  Charles Whitmer ,  Lowell L. Wood, JR. ,  Victoria Y.H. Wood

IPC分类号： G06K9/00 ,  G06K9/40

CPC分类号： G06T5/006 ,  G06T2207/30012

摘要： Certain aspects can relate to responsive to the at least some input compensating information, imaging the at least the portion of the individual in a manner to limit at least some distorting effects of the at least the portion of the at least one distorting feature associated with the at least the portion of the individual at least partially by modifying a non-optical electromagnetic output from an imaging modality as applied to the at least the portion of the at least one distorting feature associated with the at least the portion of the individual. Certain aspects can relate to creating at least one conformal absence of a non-optical electromagnetic output to limit distortion to an imaging of an at least a portion of an individual resulting at least partially from at least one distorting feature associated with the at least the portion of the individual.