METHOD FOR MAKING INSULIN PRECURSORS AND INSULIN PRECURSOR ANALOGUES HAVING IMPROVED FERMENTATION YIELD IN YEAST
    32.
    发明申请
    METHOD FOR MAKING INSULIN PRECURSORS AND INSULIN PRECURSOR ANALOGUES HAVING IMPROVED FERMENTATION YIELD IN YEAST 有权
    用于制造胰岛素前体和胰岛素前体类似物的方法具有改善的发酵产量在YEAST

    公开(公告)号:US20090017497A1

    公开(公告)日:2009-01-15

    申请号:US12104809

    申请日:2008-04-17

    IPC分类号: C12N15/17

    CPC分类号: C07K14/62

    摘要: Novel insulin precursors and insulin precursor analogs comprising a connecting peptide (mini C-peptide) of preferably up to 15 amino acid residues and comprising at least one Gly are provided. The precursors can be converted into human insulin or a human insulin analog. The precursors will typically have a distance between B27 (atom CG2) and A1 (atom CA) of less than 5 Å.

    摘要翻译: 提供了包含优选至多15个氨基酸残基并且包含至少一个Gly的连接肽(小C肽)的新型胰岛素前体和胰岛素前体类似物。 前体可转化为人胰岛素或人胰岛素类似物。 前体通常具有小于5埃的B27(原子CG2)和A1(原子CA)之间的距离。