公开(公告)号：US09821011B1

公开(公告)日：2017-11-21

申请号：US15383717

申请日：2016-12-19

Applicant: THE TRUSTEES OF DARTMOUTH COLLEGE

Inventor： Charles L. Sentman

IPC: C12N5/10 ,  A61K35/17 ,  C12N5/0783 ,  A61K35/12

CPC classification number: C12N5/0636 ,  A61K35/17 ,  A61K39/0011 ,  A61K2035/124 ,  A61K2039/5156 ,  A61K2039/585 ,  C12N2501/515 ,  C12N2510/02 ,  C12N2511/00

Abstract: The invention is directed to modified T cells, methods of making and using isolated, modified T cells, and methods of using these isolated, modified T cells to address diseases and disorders. In one embodiment, this invention broadly relates to TCR-deficient T cells, isolated populations thereof, and compositions comprising the same. In another embodiment of the invention, these TCR-deficient T cells are designed to express a functional non-TCR receptor. The invention also pertains to methods of making said TCR-deficient T cells, and methods of reducing or ameliorating, or preventing or treating, diseases and disorders using said TCR-deficient T cells, populations thereof, or compositions comprising the same.

公开(公告)号：US20160312182A1

公开(公告)日：2016-10-27

申请号：US15003968

申请日：2016-01-22

Applicant: THE TRUSTEES OF DARTMOUTH COLLEGE

Inventor： Charles L. Sentman

IPC: C12N5/0783

CPC classification number: C12N5/0636 ,  A61K2039/5156 ,  C12N2501/515

Abstract: The invention is directed to modified T cells, methods of making and using isolated, modified T cells, and methods of using these isolated, modified T cells to address diseases and disorders. In one embodiment, this invention broadly relates to TCR-deficient T cells, isolated populations thereof, and compositions comprising the same. In another embodiment of the invention, these TCR-deficient T cells are designed to express a functional non-TCR receptor. The invention also pertains to methods of making said TCR-deficient T cells, and methods of reducing or ameliorating, or preventing or treating, diseases and disorders using said TCR-deficient T cells, populations thereof, or compositions comprising the same.

Abstract translation: 本发明涉及修饰的T细胞，制备和使用分离的，修饰的T细胞的方法，以及使用这些分离的，修饰的T细胞来解决疾病和病症的方法。 在一个实施方案中，本发明广泛涉及TCR缺陷的T细胞，其分离的群体，以及包含其的组合物。 在本发明的另一个实施方案中，将这些TCR缺陷型T细胞设计为表达功能性非TCR受体。 本发明还涉及制备所述TCR缺陷型T细胞的方法，以及使用所述TCR缺陷型T细胞，其群体或包含该T细胞的组合物减少或改善或预防或治疗疾病和病症的方法。