公开(公告)号：US20210121562A1

公开(公告)日：2021-04-29

申请号：US17043537

申请日：2019-03-29

Applicant: TORAY INDUSTRIES, INC.

Inventor： Fumiyoshi OKANO ,  Takanori SAITO

IPC: A61K39/395 ,  A61K31/437 ,  A61P35/00 ,  A61K31/337 ,  A61P35/02

Abstract: A medicament for treatment and/or prevention of cancer, comprising an antibody or a fragment thereof having an immunological reactivity with a CAPRIN-1 protein, and imiquimod together or separately in combination can treat and/or prevent cancer specifically expressing CAPRIN-1 protein on a cell surface.

公开(公告)号：US20190076505A1

公开(公告)日：2019-03-14

申请号：US16080857

申请日：2017-03-01

Applicant: TORAY INDUSTRIES, INC.

Inventor： Akira KURIHARA ,  Fumiyoshi OKANO

IPC: A61K38/17 ,  A61P35/00 ,  A61K35/76 ,  C12N15/62 ,  A61K35/15

Abstract: The present invention addresses the problem of finding a novel peptide useful as an active ingredient in an agent for treating or preventing cancer, and to provide the use of the polypeptide as an immune inducer.The immune inducer containing as an active ingredient: (a) a polypeptide consisting of any one of the amino acid sequences represented by SEQ ID NOs: 3 to 45; or (b) a polypeptide comprising one to several amino acid deletions, substitutions or additions in the amino acid sequence of the polypeptide (a); is useful as an agent for treating or preventing cancer, etc.

公开(公告)号：US20180092967A1

公开(公告)日：2018-04-05

申请号：US15567448

申请日：2016-04-28

Applicant: TORAY INDUSTRIES, INC.

Inventor： Akira KURIHARA ,  Fumiyoshi OKANO

IPC: A61K39/00

CPC classification number: A61K39/0011 ,  A61K31/7088 ,  A61K35/15 ,  A61K35/17 ,  A61K39/00 ,  A61K48/00 ,  A61K2039/5154 ,  A61K2039/5158 ,  A61K2039/53 ,  A61K2039/572 ,  A61P35/00 ,  A61P35/02

Abstract: This application provides an immunity-inducing agent comprising, as an active ingredient, at least one polypeptide having immunity-inducing activity and selected from (a) polypeptides consisting of amino acid sequences represented by SEQ ID NO: 8, 4, 6, 10, 12, 2 and 14, and polypeptides consisting of 7 or more consecutive amino acids in the amino acid sequences, (b) polypeptides having a sequence identity of 85% or more with the amino acid sequences represented by SEQ ID NO: 8, 4, 6, 10, 12, 2 and 14, and polypeptides consisting of 7 or more consecutive amino acids in the amino acid sequences, and (c) polypeptides comprising the polypeptides according to (a) or (b) as the partial sequences, or a recombinant vector comprising a polynucleotide encoding the polypeptide and capable of expressing the polypeptide in vivo.

公开(公告)号：US20160208014A1

公开(公告)日：2016-07-21

申请号：US15092469

申请日：2016-04-06

Applicant: TORAY INDUSTRIES, INC.

Inventor： Fumiyoshi OKANO ,  Takayoshi IDO ,  Takanori SAITO ,  Shinichi KOBAYASHI

IPC: C07K16/30

CPC classification number: C07K16/3015 ,  A61K39/39558 ,  A61K2039/505 ,  C07K16/30 ,  C07K16/3053 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/565 ,  C07K2317/732 ,  C07K2317/734

Abstract: The present invention relates to a pharmaceutical composition for treatment and/or prevention of cancer, which comprises, as an active ingredient, an antibody or fragment thereof having an immunological reactivity with a CAPRIN-1 protein or a fragment thereof comprising 7 or more consecutive amino acids.

Abstract translation: 本发明涉及用于治疗和/或预防癌症的药物组合物，其包含与包含7个或更多个连续氨基酸的CAPRIN-1蛋白或其片段具有免疫学反应性的抗体或其片段作为活性成分 酸。

公开(公告)号：US20160030540A1

公开(公告)日：2016-02-04

申请号：US14882307

申请日：2015-10-13

Applicant: TORAY INDUSTRIES, INC.

Inventor： Akira KURIHARA ,  Fumiyoshi OKANO

IPC: A61K39/00

Abstract: Provided is a method for inducing immunity for therapy of a cancer(s). The method includes the step of administering to an individual with cancer at least one polypeptide selected from the polypeptides (a) or (b) below, and/or a recombinant vector(s) that comprise(s) a polynucleotide(s) encoding the at least one polypeptide, the recombinant vector(s) being capable of expressing the polypeptide(s) in vivo: (a) a polypeptide in any one of the amino acid sequences of SEQ ID NOs: 2, 4, 8, 10 and 12; and (b) a polypeptide having a sequence identity of not less than 95% to the polypeptide (a).

Abstract translation: 提供了用于诱导癌症治疗免疫的方法。 该方法包括向个体给予患有至少一种选自下述多肽（a）或（b）的多肽的个体和/或重组载体的步骤，所述重组载体包含编码 至少一种多肽，所述重组载体能够在体内表达多肽：（a）SEQ ID NO：2,4,8,10和12的任一氨基酸序列中的多肽 ; 和（b）与多肽（a）具有不小于95％的序列同一性的多肽。