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    IMMUNITY-INDUCING AGENT
    3.
    发明申请
    IMMUNITY-INDUCING AGENT 审中-公开
    免疫诱导剂

    公开(公告)号：US20160136252A1

    公开(公告)日：2016-05-19

    申请号：US15008101

    申请日：2016-01-27

    Applicant: TORAY INDUSTRIES, INC.

    Inventor： Akira KURIHARA ,  Fumiyoshi OKANO

    IPC: A61K39/00 ,  C12N5/0783 ,  C12Q1/68 ,  C12N5/0784

    CPC classification number: A61K39/0011 ,  A61K35/17 ,  A61K38/16 ,  C12N5/0636 ,  C12N5/0639 ,  C12Q1/6886 ,  C12Q2600/158

    Abstract: An immunity-inducing agent comprising as an effective ingredient(s) a polypeptide(s) selected from the polypeptides: (a) a polypeptide consisting essentially of not less than 7 consecutive amino acids in any one of the amino acid sequences shown in SEQ ID NOs:2, 4, 6, 8, 10, 12 and 44 in SEQUENCE LISTING; (b) a polypeptide having a sequence identity of not less than 90% with the polypeptide (a) and consisting essentially of not less than 7 amino acids; and (c) a polypeptide comprising the polypeptide (a) or (b) as a partial sequence thereof; which polypeptide(s) has/have an immunity-inducing activity/activities, or as an effective ingredient(s) a recombinant vector(s) which comprise(s) a polynucleotide(s) encoding the polypeptide(s) and is/are capable of expressing the polypeptide(s) in vivo, is useful as a therapeutic and/or prophylactic agent for cancer, and/or the like.

    Abstract translation: 一种免疫诱导剂，其包含选自以下多肽作为有效成分的多肽：（a）基本上由SEQ ID NO：1所示氨基酸序列中的任一个中不少于7个连续氨基酸组成的多肽 序号：2，4，6，8，10，12和44; （b）与多肽（a）具有不小于90％的序列同一性并且基本上由不少于7个氨基酸组成的多肽; 和（c）包含多肽（a）或（b）作为其部分序列的多肽; 哪些多肽具有/具有免疫诱导活性/活性，或作为有效成分的重组载体，其包含编码多肽的多核苷酸并且是/ 能够在体内表达多肽，可用作癌症的治疗和/或预防剂和/或类似物。

    IMMUNITY INDUCER
    4.
    发明申请
    IMMUNITY INDUCER 审中-公开

    公开(公告)号：US20190076505A1

    公开(公告)日：2019-03-14

    申请号：US16080857

    申请日：2017-03-01

    Applicant: TORAY INDUSTRIES, INC.

    Inventor： Akira KURIHARA ,  Fumiyoshi OKANO

    IPC: A61K38/17 ,  A61P35/00 ,  A61K35/76 ,  C12N15/62 ,  A61K35/15

    Abstract: The present invention addresses the problem of finding a novel peptide useful as an active ingredient in an agent for treating or preventing cancer, and to provide the use of the polypeptide as an immune inducer.The immune inducer containing as an active ingredient: (a) a polypeptide consisting of any one of the amino acid sequences represented by SEQ ID NOs: 3 to 45; or (b) a polypeptide comprising one to several amino acid deletions, substitutions or additions in the amino acid sequence of the polypeptide (a); is useful as an agent for treating or preventing cancer, etc.

    IMMUNITY-INDUCING AGENT
    5.
    发明申请
    IMMUNITY-INDUCING AGENT 审中-公开

    公开(公告)号：US20180092967A1

    公开(公告)日：2018-04-05

    申请号：US15567448

    申请日：2016-04-28

    Applicant: TORAY INDUSTRIES, INC.

    Inventor： Akira KURIHARA ,  Fumiyoshi OKANO

    IPC: A61K39/00

    CPC classification number: A61K39/0011 ,  A61K31/7088 ,  A61K35/15 ,  A61K35/17 ,  A61K39/00 ,  A61K48/00 ,  A61K2039/5154 ,  A61K2039/5158 ,  A61K2039/53 ,  A61K2039/572 ,  A61P35/00 ,  A61P35/02

    Abstract: This application provides an immunity-inducing agent comprising, as an active ingredient, at least one polypeptide having immunity-inducing activity and selected from (a) polypeptides consisting of amino acid sequences represented by SEQ ID NO: 8, 4, 6, 10, 12, 2 and 14, and polypeptides consisting of 7 or more consecutive amino acids in the amino acid sequences, (b) polypeptides having a sequence identity of 85% or more with the amino acid sequences represented by SEQ ID NO: 8, 4, 6, 10, 12, 2 and 14, and polypeptides consisting of 7 or more consecutive amino acids in the amino acid sequences, and (c) polypeptides comprising the polypeptides according to (a) or (b) as the partial sequences, or a recombinant vector comprising a polynucleotide encoding the polypeptide and capable of expressing the polypeptide in vivo.

    IMMUNITY INDUCING AGENT
    6.
    发明申请
    IMMUNITY INDUCING AGENT 审中-公开
    免疫诱导剂

    公开(公告)号：US20160030540A1

    公开(公告)日：2016-02-04

    申请号：US14882307

    申请日：2015-10-13

    Applicant: TORAY INDUSTRIES, INC.

    Inventor： Akira KURIHARA ,  Fumiyoshi OKANO

    IPC: A61K39/00

    Abstract: Provided is a method for inducing immunity for therapy of a cancer(s). The method includes the step of administering to an individual with cancer at least one polypeptide selected from the polypeptides (a) or (b) below, and/or a recombinant vector(s) that comprise(s) a polynucleotide(s) encoding the at least one polypeptide, the recombinant vector(s) being capable of expressing the polypeptide(s) in vivo: (a) a polypeptide in any one of the amino acid sequences of SEQ ID NOs: 2, 4, 8, 10 and 12; and (b) a polypeptide having a sequence identity of not less than 95% to the polypeptide (a).

    Abstract translation: 提供了用于诱导癌症治疗免疫的方法。 该方法包括向个体给予患有至少一种选自下述多肽（a）或（b）的多肽的个体和/或重组载体的步骤，所述重组载体包含编码 至少一种多肽，所述重组载体能够在体内表达多肽：（a）SEQ ID NO：2,4,8,10和12的任一氨基酸序列中的多肽 ; 和（b）与多肽（a）具有不小于95％的序列同一性的多肽。

    PHARMACEUTICAL COMPOSITION FOR TREATING AND/OR PREVENTING CANCER
    7.
    发明申请
    PHARMACEUTICAL COMPOSITION FOR TREATING AND/OR PREVENTING CANCER 审中-公开

    公开(公告)号：US20180085453A1

    公开(公告)日：2018-03-29

    申请号：US15567496

    申请日：2016-04-28

    Applicant: TORAY INDUSTRIES, INC.

    Inventor： Akira KURIHARA ,  Hyongi CHON ,  Takayuki FUJITA ,  Fumiyoshi OKANO

    IPC: A61K39/395 ,  C07K4/12

    Abstract: An object of the present invention is to identify a cancer antigen protein specifically expressed on the surface of cancer cells and provide use of an antibody targeting the cancer antigen protein as a therapeutic and/or prophylactic agent for cancer. A pharmaceutical composition for treating and/or preventing cancer comprising an antibody or a fragment thereof having immunological reactivity with CSPG5 protein consisting of any one of amino acid sequences represented by SEQ ID NOs: 8, 4, 6, 10, and 12 and an amino acid sequence having an amino acid identity of 80% or more to the amino acid sequence, or a fragment thereof consisting of 7 or more consecutive amino acids, as an active ingredient.

    IMMUNITY INDUCTION AGENT
    8.
    发明申请
    IMMUNITY INDUCTION AGENT 审中-公开
    免疫诱导剂

    公开(公告)号：US20160106823A1

    公开(公告)日：2016-04-21

    申请号：US14869523

    申请日：2015-09-29

    Applicant: TORAY INDUSTRIES, INC.

    Inventor： Akira KURIHARA ,  Fumiyoshi OKANO

    IPC: A61K39/00 ,  A61K39/39

    CPC classification number: A61K39/0011 ,  A61K38/20 ,  A61K38/21 ,  A61K38/44 ,  A61K39/39 ,  C12N9/0071 ,  A61K2300/00

    Abstract: Provided is a method for inducing immunity for therapy of a cancer(s). The method includes the step of administering to an individual with cancer at least one polypeptide selected from the polypeptides (a) or (b) below, and/or a recombinant vector(s) that comprise(s) a polynucleotide(s) encoding the at least one polypeptide, the recombinant vector(s) being capable of expressing the polypeptide(s) in vivo: (a) a polypeptide in any one of the amino acid sequences of SEQ ID NOs: 2, 4, 22, or 24; and (b) a polypeptide having a sequence identity of not less than 95% to the polypeptide (a). Further, an in vitro method for preparing an antigen-presenting cell is provided. The method includes the step of contacting the antigen-presenting cell with the at least one polypeptide selected from: (a) a polypeptide in any one of the amino acid sequences of SEQ ID NOs: 2, 4, 22, or 24; and (b) a polypeptide having a sequence identity of not less than 95% to the polypeptide (a).

    Abstract translation: 提供了用于诱导癌症治疗免疫的方法。 该方法包括向个体给予患有至少一种选自下述多肽（a）或（b）的多肽的个体和/或重组载体的步骤，所述重组载体包含编码 至少一种多肽，能够在体内表达多肽的重组载体：（a）SEQ ID NO：2,4,22或24的任一氨基酸序列中的多肽; 和（b）与多肽（a）具有不小于95％的序列同一性的多肽。 此外，提供了制备抗原呈递细胞的体外方法。 该方法包括使抗原呈递细胞与选自以下的至少一种多肽接触的步骤：（a）SEQ ID NO：2,4,22或24的任一氨基酸序列中的多肽; 和（b）与多肽（a）具有不小于95％的序列同一性的多肽。

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