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    Bone morphogenetic protein antagonist based on the mature protein
    32.
    发明授权
    Bone morphogenetic protein antagonist based on the mature protein 有权
    基于成熟蛋白的骨形态发生蛋白拮抗剂

    公开(公告)号：US07132397B1

    公开(公告)日：2006-11-07

    申请号：US09806368

    申请日：1999-10-04

    申请人： Mieko Katsuura ,  Michio Kimura

    发明人： Mieko Katsuura ,  Michio Kimura

    IPC分类号： A61K38/18 ,  C07K14/51

    CPC分类号： C07K14/51 ,  A61K38/00

    摘要： The purpose is to provide a mature protein having an antagonistic activity against bone morphogenetic proteins. The mature protein having an antagonistic activity against bone morphogenetic proteins is obtained by converting at least one residue among methionine residues or tryptophane residues existing in the amino acid sequence of mature human MP52 (SEQ ID No 1) to a hydrophilic residue by chemical modification, or replacing said residues with a hydrophilic amino acid residue or a polar amino acid residue. The chemical modification for said methionine residue is performed by an oxidization reaction or an alkylation reaction. The chemical modification for said tryptophane residue is performed by an allylsulphenylation reaction. Or a mature protein having an antagonistic activity against bone morphogenetic proteins is obtained by converting at least one residue of tryptophane residues existing in the amino acid sequences of mature human BMP-2 (SEQ ID No 2), mature human BMP-4 (SEQ ID No 3), and mature human BMP-7 (SEQ ID No 4) to a hydrophilic residue by chemical modification, or replacing said residues with a hydrophilic amino acid residue or a polar amino acid residue.

    摘要翻译： 目的是提供对骨形态发生蛋白具有拮抗作用的成熟蛋白质。 通过化学修饰将成熟人MP52（SEQ ID No.1）的氨基酸序列中存在的甲硫氨酸残基或色氨酸残基中的至少一个残基转化成亲水性残基，获得对骨形态发生蛋白具有拮抗作用的成熟蛋白质，或 用亲水氨基酸残基或极性氨基酸残基取代所述残基。 所述甲硫氨酸残基的化学修饰通过氧化反应或烷基化反应进行。 所述色氨酸残基的化学修饰通过烯丙基苯基化反应进行。 或者通过转化成熟人BMP-2（SEQ ID No 2），成熟人BMP-4（SEQ ID No.2）的氨基酸序列中存在的色氨酸残基的至少一个残基，获得对骨形态发生蛋白具有拮抗活性的成熟蛋白质 No.3）和成熟的人BMP-7（SEQ ID No 4）通过化学修饰与亲水性残基反应，或用亲水氨基酸残基或极性氨基酸残基替代所述残基。

    Static-resistant electric initiator
    37.
    发明授权
    Static-resistant electric initiator 失效
    防静电电引发剂

    公开(公告)号：US4220088A

    公开(公告)日：1980-09-02

    申请号：US917164

    申请日：1978-06-20

    申请人： Michio Kimura ,  Nobuyuki Izawa ,  Nobuaki Sakuma

    发明人： Michio Kimura ,  Nobuyuki Izawa ,  Nobuaki Sakuma

    IPC分类号： F42B3/10 ,  F42B3/103 ,  F42B3/12 ,  F42B3/18 ,  H02H3/06 ,  H02H7/26

    CPC分类号： F42B3/103 ,  F42B3/18

    摘要： A safe static-resistant electric initiator is constructed by clamping the fitting portion of a cup having a bottom with a protruding part of a plug and the open part of a loaded shell corresponding to said plug. The electric initiator comprises an ignition device and a loaded shell having said ignition device at its open part, said ignition device comprising the cup having a bottom which is breakable by the ignition flame of an ignition composition, an ignition composition filled in said cup, the protruding part for supporting said cup and the plug provided with a bridge wire at the portions of the terminal bared parts of two leg wires which pass through the insides of the plug and said protruding part. Further, for obtaining a superior characteristic of static resistance, the material of said cup is selected, and the clamping ratio of said cup to the protruding part of the plug provided with a bridge wire and the ratio (l/a) of the fitting length (l) between said cup and said protruding part of the plug, to the outside diameter (a) of said cup, are limited to give the most effective ranges.

    摘要翻译： 通过将具有底部的杯的配合部分夹持在插头的突出部分和与所述插头相对应的加载壳体的开口部分来构造安全的防静电引发器。 电引发剂包括点火装置和装载的外壳，其开口部分具有所述点火装置，所述点火装置包括具有可由点火组合物的点火火焰破坏的底部的杯子，填充在所述杯中的点火组合物， 用于支撑所述杯的突出部分和在通过插塞和所述突出部分的内部的两根腿线的端子裸露部分的部分处设置有桥接线的插头。 此外，为了获得优异的静电特性，选择所述杯的材料，并且所述杯与插塞的突出部分的夹紧比设置有桥接线，并且配合长度的比率（l / a） 所述杯和所述插头的突出部分之间的距离（l）到所述杯的外径（a）被限制为给出最有效的范围。

    IMAGE FORMING APPARATUS
    39.
    发明申请
    IMAGE FORMING APPARATUS 有权
    图像形成装置

    公开(公告)号：US20120183310A1

    公开(公告)日：2012-07-19

    申请号：US13348062

    申请日：2012-01-11

    申请人： Tomoharu Asano ,  Takaaki Ikegami ,  Michio Kimura

    发明人： Tomoharu Asano ,  Takaaki Ikegami ,  Michio Kimura

    IPC分类号： G03G15/00

    CPC分类号： G03G15/5037 ,  G03G15/553 ,  G03G21/1671

    摘要： An image forming apparatus having an image bearing member, a charger to charge the surface of the image bearing member, an irradiator to irradiate the image bearing member to form the latent image, a developing device to develop the latent electrostatic image with toner to obtain a visible image, a transfer device to transfer the visible image to a transfer medium by a transfer bias applied to a transfer area between the image bearing member and the transfer member, and a voltage detector to measure a first surface voltage and a second surface voltage under different conditions, and a life expectancy identification device to identify whether or when the expected working life of the image bearing member has come to the end based on a comparison of the first surface voltage and the second surface voltage.

    摘要翻译： 一种具有图像承载部件的图像形成装置，对图像承载部件的表面充电的充电器，用于照射图像承载部件以形成潜像的照射器，用调色剂显影静电潜像的显影装置， 可见图像，通过施加到图像承载部件和转印部件之间的转印区域的转印偏压将可见图像转印到转印介质的转印装置，以及电压检测器，用于测量第一表面电压和第二表面电压 不同的条件，以及预期寿命识别装置，用于基于第一表面电压和第二表面电压的比较来确定图像承载部件的预期使用寿命是否或何时已经到了最后。

    Electrophotographic photoconductor, method for producing the same, image forming process, image forming apparatus and process cartridge
    40.
    发明授权
    Electrophotographic photoconductor, method for producing the same, image forming process, image forming apparatus and process cartridge 有权
    电子照相感光体，其制造方法，成像工艺，成像设备和处理盒

    公开(公告)号：US07851119B2

    公开(公告)日：2010-12-14

    申请号：US11850394

    申请日：2007-09-05

    申请人： Tetsuya Toshine ,  Chiaki Tanaka ,  Michio Kimura ,  Tomoyuki Shimada ,  Nozomu Tamoto ,  Yoshiki Yanagawa ,  Hiromi Tada

    发明人： Tetsuya Toshine ,  Chiaki Tanaka ,  Michio Kimura ,  Tomoyuki Shimada ,  Nozomu Tamoto ,  Yoshiki Yanagawa ,  Hiromi Tada

    IPC分类号： G03G7/00

    CPC分类号： G03G5/051 ,  G03G5/0514 ,  G03G5/0517 ,  G03G5/0521 ,  G03G5/0525 ,  G03G5/0532 ,  G03G5/0535 ,  G03G5/0578 ,  G03G5/14786 ,  G03G5/14791 ,  G03G5/14795

    摘要： The present invention provides an electrophotographic photoconductor capable of reducing latent electrostatic image stability defects caused by adhesion/adsorption of an electric discharge product formed by a charger in an image forming process, degradation of charge transportability and cleaning defects caused when removing a residual toner. The electrophotographic photoconductor has a conductive substrate, and a photosensitive layer which contains at least a binder, a charge generating material and a charge transporting material and is formed on the substrate, wherein the photosensitive layer contains an injection material composed of at least any one of one wax selected from paraffin waxes, Fisher-Tropsh waxes, polyolefin waxes and a polyorganosiloxane compound in an area from the surface of the photosensitive layer to 50% of the thickness thereof in the thickness direction of the electrophotographic photoconductor, and the content of the injection material is 3% by mass or more to the content of the binder.

    摘要翻译： 本发明提供了一种电子照相感光体，其能够降低在图像形成过程中由充电器形成的放电产物的附着/吸附引起的静电潜像稳定性缺陷，电荷输送性降低和清除残留调色剂时引起的清洁缺陷。 电子照相感光体具有导电性基材和至少含有粘合剂，电荷产生材料和电荷输送材料并形成在基材上的感光层，其中感光层含有由以下的至少一种构成的注入材料： 在感光层的表面至电子照相感光体的厚度方向的50％的范围内，选自石蜡，Fisher-Tropsh蜡，聚烯烃蜡和聚有机硅氧烷化合物的一种蜡，以及注射用量 材料相对于粘合剂的含量为3质量％以上。