公开(公告)号：US20060247303A1

公开(公告)日：2006-11-02

申请号：US10531881

申请日：2003-10-21

申请人： Hilmar Bischoff ,  Frank-Thorsten Hafner ,  Carsten Schmeck ,  Joachim Telser ,  Alexandros Vakalopoulos ,  Gabriele Wirtz ,  Marcus Bauser ,  David Bruckner ,  Martina Wuttke

发明人： Hilmar Bischoff ,  Frank-Thorsten Hafner ,  Carsten Schmeck ,  Joachim Telser ,  Alexandros Vakalopoulos ,  Gabriele Wirtz ,  Marcus Bauser ,  David Bruckner ,  Martina Wuttke

IPC分类号： A61K31/365 ,  C07D321/02

CPC分类号： A61K31/365 ,  C07D321/12

摘要： The present invention relates to substituted 7H-dibenzo[b,g][1,5]dioxocin-5-one-derivatives, to processes for their preparation and to their use in medicaments, in particular as inhibitors of the cholesterol ester transfer protein (CETP) for the treatment and/or prevention of cardiovascular disorders, in particular hypolipoproteinaemia, dyslipidaemias, hypertriglyceridaemias, hyperlipidaemias and arteriosclerosis.

摘要翻译： 本发明涉及取代的7H-二苯并[b，g] [1,5]二氧环辛-5-酮衍生物，其制备方法及其在药物中的用途，特别是胆固醇酯转移蛋白的抑制剂 CETP）用于治疗和/或预防心血管疾病，特别是低脂蛋白血症，血脂异常，高甘油三酯血症，高脂血症和动脉硬化。