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公开(公告)号：US08227511B2
公开(公告)日：2012-07-24
申请号：US12225211
申请日：2007-03-07
申请人： Carsten Schmeck , Hilmar Bischoff , Volkhart Li , Klemens Lustig , Michael Thutewohl , Alexandros Vakalopoulos , Olaf Weber
发明人： Carsten Schmeck , Hilmar Bischoff , Volkhart Li , Klemens Lustig , Michael Thutewohl , Alexandros Vakalopoulos , Olaf Weber
IPC分类号： A61K31/352 , C07D311/04 , C07D311/96
CPC分类号： C07D311/22 , C07D311/96
摘要： The present invention relates to substituted chromanol derivatives, to processes for their preparation, to their use on their own or in combination for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular disorders.
摘要翻译： 本发明涉及取代的苯并二氢吡喃衍生物，其制备方法，其自身用途或组合用于治疗和/或预防疾病及其用于制备用于治疗和/或预防疾病的药物的用途， 特别是用于治疗和/或预防心血管疾病。
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2.发明授权Substituted arylimidazolone and triazolone as inhibitors of vasopressin receptors 有权取代的芳基咪唑啉酮和三唑酮作为加压素受体的抑制剂公开(公告)号：US08084481B2
公开(公告)日：2011-12-27
申请号：US12301616
申请日：2007-05-21
申请人： Heinrich Meier , Eckhard Bender , Ulf Brüggemeier , Ingo Flamme , Dagmar Karthaus , Peter Kolkhof , Daniel Meibom , Dirk Schneider , Verena Voehringer , Chantal Fürstner , Jörg Keldenich , Dieter Lang , Elisabeth Pook , Carsten Schmeck
发明人： Heinrich Meier , Eckhard Bender , Ulf Brüggemeier , Ingo Flamme , Dagmar Karthaus , Peter Kolkhof , Daniel Meibom , Dirk Schneider , Verena Voehringer , Chantal Fürstner , Jörg Keldenich , Dieter Lang , Elisabeth Pook , Carsten Schmeck
IPC分类号： A61K31/41 , A61K31/415 , C07D249/00 , C07D233/00
CPC分类号： C07D249/12 , C07D233/70 , C07D401/12 , C07D403/12 , C07D409/04 , C07D409/14
摘要： The present application relates to novel, substituted 4-arylimidazol-2-ones and 5-aryl-1,2,4-triazolones, processes for the production thereof, the use thereof alone or in combinations for the treatment and/or prevention of diseases and the use thereof for the production of medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular diseases.
摘要翻译： 本申请涉及新的取代的4-芳基咪唑-2-酮和5-芳基-1,2,4-三唑烷酮，其制备方法，其单独使用或组合用于治疗和/或预防疾病 以及其用于生产用于治疗和/或预防疾病的药物的用途，特别是用于治疗和/或预防心血管疾病。
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3.发明申请公开(公告)号：US20100261771A1
公开(公告)日：2010-10-14
申请号：US12727044
申请日：2010-03-18
申请人： Ulf Brüggemeier , Chantal Fürstner , Volker Geiss , Joerg Keldenich , Armin Kern , Martina Delbeck , Peter Kolkhof , Axel Kretschmer , Elisabeth Pook , Carsten Schmeck , Hubert Trübel
发明人： Ulf Brüggemeier , Chantal Fürstner , Volker Geiss , Joerg Keldenich , Armin Kern , Martina Delbeck , Peter Kolkhof , Axel Kretschmer , Elisabeth Pook , Carsten Schmeck , Hubert Trübel
IPC分类号： A61K31/422 , C07D249/12 , A61K31/4196 , C07D413/12 , A61P1/16 , A61P7/10 , A61P9/00
CPC分类号： C07D233/70 , A61K9/0095 , A61K9/2054 , A61K31/4166 , A61K31/4196 , A61K31/422 , A61K45/06 , C07D249/12 , C07D409/04 , C07D413/12 , A61K2300/00
摘要： The present application relates to new, substituted 2-acetamido-5-aryl-1,2,4-triazolones, to processes for preparing them, to their use alone or in combinations for the treatment and/or prevention of diseases and also to their use for the production of medicaments for the treatment and/or prevention of diseases, more particularly for the treatment and/or prevention of cardiovascular disorders.
摘要翻译： 本申请涉及新的取代的2-乙酰氨基-5-芳基-1,2,4-三唑酮，用于制备它们的方法，单独使用或组合用于治疗和/或预防疾病，以及它们 用于生产用于治疗和/或预防疾病的药物，更具体地用于治疗和/或预防心血管疾病。
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公开(公告)号：US20060069112A1
公开(公告)日：2006-03-30
申请号：US11257931
申请日：2005-10-25
申请人： Jürgen Stoltefuß , Michael Lörges , Gunter Schmidt , Arndt Brandes , Carsten Schmeck , Klaus-Dieter Bremm , Hilmar Bischoff , Delf Schmidt
发明人： Jürgen Stoltefuß , Michael Lörges , Gunter Schmidt , Arndt Brandes , Carsten Schmeck , Klaus-Dieter Bremm , Hilmar Bischoff , Delf Schmidt
IPC分类号： A61K31/4747 , A61K31/4709 , C07D405/02
CPC分类号： C07D401/04 , C07D215/20 , C07D409/04
摘要： Hetero-tetrahydroquinolines can be prepared either by condensing correspondingly substituted hetero-tetrahydroquinoline aldehydes with the desired substituent or by reducing the corresponding keto-substituted hetero-tetrahydroquinolines, followed by introduction of the desired substituent by customary methods. The hetero-tetrahydroquinolines are suitable for use as active compounds in medicaments, in particular in medicaments for treating artheriosclerosis and dyslipidaemias.
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5.发明授权4-Phenyltetrahydrochinoline utilized as an inhibitor of the cholesterol ester transfer protein 失效4-苯基四氢喹啉用作胆固醇酯转移蛋白的抑制剂公开(公告)号：US06897317B2
公开(公告)日：2005-05-24
申请号：US10403575
申请日：2003-03-31
申请人： Gunter Schmidt , Jürgen Stoltefuss , Michael Lögers , Arndt Brandes , Carsten Schmeck , Klaus-Dieter Bremm , Hilmar Bischoff , Delf Schmidt
发明人： Gunter Schmidt , Jürgen Stoltefuss , Michael Lögers , Arndt Brandes , Carsten Schmeck , Klaus-Dieter Bremm , Hilmar Bischoff , Delf Schmidt
IPC分类号： A61K31/47 , A61K31/4709 , A61K31/506 , A61P3/06 , A61P9/10 , C07D215/20 , C07D221/20 , C07D401/06 , C07D417/06 , C07D215/36
CPC分类号： C07D221/20 , C07D215/20 , C07D401/06 , C07D417/06
摘要： The tetrahydroquinolines can be prepared by condensing appropriately substituted tetrahydroquinoline aldehydes with suitable substances and subsequently varying the substituents present by customary methods. The tetrahydroquinolines are suitable as active compounds in medicaments, in particular in medicaments for the treatment of arteriosclerosis and dyslipidaemias.
摘要翻译： 四氢喹啉可以通过将适当取代的四氢喹啉醛与合适的物质缩合并随后通过常规方法改变存在的取代基来制备。 四氢喹啉适合作为药物中的活性化合物，特别是用于治疗动脉硬化和血脂障碍的药物。
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公开(公告)号：US06867206B1
公开(公告)日：2005-03-15
申请号：US10018927
申请日：2000-06-16
申请人： Jürgen Stoltefuss , Gabriele Bräunlich , Michael Lögers , Carsten Schmeck , Ulrich Nielsch , Martin Bechem , Christoph Gerdes , Michael Sperzel , Klemens Lustig , Werner Stürmer
发明人： Jürgen Stoltefuss , Gabriele Bräunlich , Michael Lögers , Carsten Schmeck , Ulrich Nielsch , Martin Bechem , Christoph Gerdes , Michael Sperzel , Klemens Lustig , Werner Stürmer
IPC分类号： A61K31/50 , A61K31/501 , A61K31/5377 , A61P7/06 , A61P43/00 , C07D237/04 , C07D401/10 , C07D401/12 , C07D405/12 , C07D409/12 , C07D417/12
CPC分类号： C07D401/10 , C07D237/04 , C07D401/12 , C07D409/12 , C07D417/12
摘要： The present invention relates to 6-carboxyphenyldihydropyridazinone derivatives having the formula wherein R1, R2, R3, A, D, G, and E are as defined in the specification and claims, a process for preparing these materials, pharmaceutical compositions containing them, and a method for using them in the treatment of anemias.
摘要翻译： 本发明涉及具有方解石R 1，R 2，R 3，A，D，G和E的6-羧基苯基二氢哒嗪酮衍生物如说明书和权利要求中所定义，制备这些材料的方法 ，含有它们的药物组合物，以及用于治疗贫血的方法。
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7.发明申请3-'Hydroxy-(-4-trifluoromethylphenyl)-methyl-7-spirocyclobutyl-5,6,7 8-tetrahydroquinolin-5-ol derivatives and the use of the same as cholesterol ester transfer protein (cetp) inhibitors 审中-公开3-羟基 - （ - 4-三氟甲基苯基） - 甲基-7-螺环丁基-5,6,7,8-四氢喹啉-5-醇衍生物及其与胆固醇酯转移蛋白（cetp）抑制剂的用途公开(公告)号：US20050043341A1
公开(公告)日：2005-02-24
申请号：US10491465
申请日：2002-09-18
申请人： Heike Gielen , Siegfried Goldmann , Jorg Keldenich , Holger Paulsen , Carsten Schmeck , Stephan Siegel , Hilmar Bischoff , Martin Raabe , Delf Schmidt , Christiane Faeste
发明人： Heike Gielen , Siegfried Goldmann , Jorg Keldenich , Holger Paulsen , Carsten Schmeck , Stephan Siegel , Hilmar Bischoff , Martin Raabe , Delf Schmidt , Christiane Faeste
IPC分类号： C07D215/20 , A61K31/47 , A61K31/4709 , A61P3/04 , A61P3/06 , A61P9/00 , A61P9/10 , A61P25/28 , A61P43/00 , C07D221/20 , C07D409/04 , A61K31/4747
CPC分类号： C07D221/20 , C07D409/04
摘要： The application relates to substituted tetrahydroquinoline derivatives, processes for their preparation and their use in medicaments.
摘要翻译： 本申请涉及取代的四氢喹啉衍生物，其制备方法及其在药物中的用途。
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8.发明授权Tetrahydroquinolines, processes for their preparation, pharmaceutical compositions containing them, and their use to prevent or treat hyperlipoproteinaemia 失效四氢喹啉，其制备方法，含有它们的药物组合物及其用于预防或治疗高脂蛋白血症公开(公告)号：US06291477B1
公开(公告)日：2001-09-18
申请号：US09508483
申请日：2000-03-10
申请人： Gunter Schmidt , Jürgen Stoltefuss , Michael Lögers , Arndt Brandes , Carsten Schmeck , Klaus-Dieter Bremm , Hilmar Bischoff , Delf Schmidt
发明人： Gunter Schmidt , Jürgen Stoltefuss , Michael Lögers , Arndt Brandes , Carsten Schmeck , Klaus-Dieter Bremm , Hilmar Bischoff , Delf Schmidt
IPC分类号： A61K31505
CPC分类号： C07D221/20 , C07D215/20 , C07D401/06 , C07D417/06
摘要： The tetrahydroquinolines can be prepared by condensing appropriately substituted tetrahydroquinoline aldehydes with suitable substances and subsequently varying the substituents present by customary methods. The tetrahydroquinolines are suitable as active compounds in medicaments, in particular in medicaments for the treatment of arteriosclerosis and dyslipidaemias.
摘要翻译： 四氢喹啉可以通过将适当取代的四氢喹啉醛与合适的物质缩合并随后通过常规方法改变存在的取代基来制备。 四氢喹啉适合作为药物中的活性化合物，特别是用于治疗动脉硬化和血脂障碍的药物。
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公开(公告)号：US06207671B1
公开(公告)日：2001-03-27
申请号：US09521648
申请日：2000-03-08
申请人： Gunter Schmidt , Arndt Brandes , Rolf Angerbauer , Michael Lögers , Matthias Müller-Gliemann , Carsten Schmeck , Klaus-Dieter Bremm , Hilmar Bischoff , Delf Schmidt , Joachim Schuhmacher , Henry Giera , Holger Paulsen , Paul Naab , Michael Conrad , Jürgen Stoltefuss
发明人： Gunter Schmidt , Arndt Brandes , Rolf Angerbauer , Michael Lögers , Matthias Müller-Gliemann , Carsten Schmeck , Klaus-Dieter Bremm , Hilmar Bischoff , Delf Schmidt , Joachim Schuhmacher , Henry Giera , Holger Paulsen , Paul Naab , Michael Conrad , Jürgen Stoltefuss
IPC分类号： A61K31438
CPC分类号： C07F7/1804
摘要： The cycloalkano-pyridines are prepared by reacting corresponding cycloalkano-pyridine-aldehydes with suitable organometallic compounds or Wittig or Grignard reagents or reacting compounds of the cycloalkano-pyridine alcohols type with suitable bromine compounds, and optionally varying the functional groups accordingly. The cycloalkanopyridines are suitable as active compounds in medicaments, in particular in medicaments for the treatment of hypertipoproteinaemia and arteriosclerosis.
摘要翻译： 通过使相应的环烷基 - 吡啶 - 醛与合适的有机金属化合物或Wittig或格氏试剂反应或使环烷基 - 吡啶醇类型的化合物与合适的溴化合物反应，并且任选地相应地改变官能团，制备环烷基 - 吡啶。 环烷基吡啶类药物适合作为药物中的活性化合物，特别是用于治疗高血脂蛋白血症和动脉硬化的药物。
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公开(公告)号：US20130231313A1
公开(公告)日：2013-09-05
申请号：US13819885
申请日：2011-09-14
申请人： Chantal Fürstner , Joerg Keldenich , Martina Delbeck , Peter Kolkhof , Axel Kretschmer , Elisabeth Pook , Carsten Schmeck , Hubert Trübel
发明人： Chantal Fürstner , Joerg Keldenich , Martina Delbeck , Peter Kolkhof , Axel Kretschmer , Elisabeth Pook , Carsten Schmeck , Hubert Trübel
IPC分类号： A61K31/4196 , C07D409/04 , A61K45/06 , C07D249/12
CPC分类号： A61K31/4196 , A61K45/06 , C07D249/12 , C07D409/04
摘要： The present application relates to novel substituted phenylacetamides and phenylpropanamides, to processes for preparing them, to their use alone or in combinations for the treatment and/or prevention of diseases and also to their use for the production of medicaments for the treatment and/or prevention of diseases, more particularly for the treatment and/or prevention of cardiovascular disorders.
摘要翻译： 本申请涉及新型取代的苯乙酰胺和苯丙酰胺，用于制备它们的方法，单独使用或组合用于治疗和/或预防疾病，以及其用于生产用于治疗和/或预防的药物的用途 的疾病，更特别地用于治疗和/或预防心血管疾病。
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