公开(公告)号：US3951963A

公开(公告)日：1976-04-20

申请号：US448376

申请日：1974-03-05

申请人： Erhardt Winkelmann ,  Ulrich Gebert ,  Wolfgang Raether

发明人： Erhardt Winkelmann ,  Ulrich Gebert ,  Wolfgang Raether

IPC分类号： C07D233/95 ,  C07D401/12 ,  C07D233/32 ,  C07D403/12 ,  C07D413/12

CPC分类号： C07D233/95

摘要： Novel 0-(dialkylaminoalkyl)-1-alkyl-5-nitroimidazole-(2)-aldoximes are described as well as their manufacture and use for treating protozoal diseases. The novel compounds correspond to the general formula ##SPC1##In which R.sup.1 stand for a hydrogen atom, a methyl, ethyl or hydroxyethyl group, Z stands for a linear or branched alkylene chain of 2 to 3 carbon atoms, and R.sup.2 and R.sup.3 each stands for an identical or different lower alkyl radical having from 1 to 4 carbon atoms or the group --NR.sup.2 R.sup.3 can be part of a saturated heterocyclic ring which may contain further substituents preferably a methyl group or/and hetero atoms, such as, especially the pyrrolidine, piperidine, morpholine, thiamorpholine, tetrahydro-1,4-thiazine-1,1-dioxide and piperazine ring, and HX can be a non-toxic, physiologically acceptable acid.

摘要翻译： 描述了新的O-（二烷基氨基烷基）-1-烷基-5-硝基咪唑 - （2） - 肟类及其制备和用于治疗原生动物疾病的用途。 所述新化合物对应于通式为：其中R 1代表氢原子，甲基，乙基或羟基乙基，Z表示2至3个碳原子的直链或支链亚烷基链，R2和R3各代表相同 或具有1至4个碳原子的不同的低级烷基或基团-NR2R3可以是饱和杂环的一部分，其可以含有其它取代基，优选甲基或/和杂原子，例如特别是吡咯烷，哌啶，吗啉 ，四氢-1,4-噻嗪-1,1-二氧化物和哌嗪环，HX可以是无毒的生理上可接受的酸。