公开(公告)号：US07129261B2

公开(公告)日：2006-10-31

申请号：US10160972

申请日：2002-05-31

申请人： Howard P. Ng ,  Danny P.C. McGee ,  Oliver L. Saunders ,  Valeri Martichonok ,  Guoxian Wu ,  Zhihong Li ,  Geoffrey T. Yarranton

发明人： Howard P. Ng ,  Danny P.C. McGee ,  Oliver L. Saunders ,  Valeri Martichonok ,  Guoxian Wu ,  Zhihong Li ,  Geoffrey T. Yarranton

IPC分类号： A61K31/40 ,  C07D487/04

CPC分类号： C07D405/06 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D405/12 ,  C07D405/14 ,  C07D487/04 ,  C07D487/10 ,  C07F7/1804 ,  C07F9/6561

摘要： The present invention provides analogues of duocarmycins that are potent cytotoxins. Also provided are peptidyl and disulfide linkers that are cleaved in vivo. The linkers are of use in forming prodrugs and conjugates of the cytotoxins of the invention as well as other diagnostic and therapeutic moieties. The invention provides prodrugs and conjugates of the duocarmycin analogues with the linker arms of the invention.