公开(公告)号：US20110306757A1

公开(公告)日：2011-12-15

申请号：US13122981

申请日：2009-10-02

申请人： Ivan Lopez-Belmonte Encina ,  Rafael Ojeda Martinez De Castilla

发明人： Ivan Lopez-Belmonte Encina ,  Rafael Ojeda Martinez De Castilla

IPC分类号： C07H15/04

CPC分类号： C07H15/04 ,  C07H15/18

摘要： Procedure for the synthesis of deprotected pentasaccharides from a protected precursor pentasaccharide through a reaction procedure having five stages whereamong is included an N-sulphation of amino groups and a hydrogenolysis of benzyl groups. Through this procedure a drastic reduction is achieved in the total synthesis time in comparison with the process traditionally employed, together with increased reproducibility thereof, permitting the standardisation thereof.

摘要翻译： 通过具有五个阶段的反应程序从被保护的前体五糖合成去保护的五糖的方法包括氨基的N-硫酸化和苄基的氢解。 通过该方法，与传统使用的方法相比，在总合成时间中实现了显着的减少，同时具有增加的再现性，允许其标准化。

公开(公告)号：US20110201572A1

公开(公告)日：2011-08-18

申请号：US13001895

申请日：2009-06-30

申请人： Ivan Lopez-Belmonte Encina ,  Maria De Los Angeles Canales Mayordomo ,  Elena Cebadera Miranda

发明人： Ivan Lopez-Belmonte Encina ,  Maria De Los Angeles Canales Mayordomo ,  Elena Cebadera Miranda

IPC分类号： A61K31/727 ,  C08B37/10 ,  A61P17/02

CPC分类号： A61K31/727 ,  A61K9/0019 ,  A61K31/726 ,  A61K47/26 ,  A61K2300/00

摘要： The invention relates to a composition of glycosaminoglycans for the treatment of diabetic foot ulcer, it specifically relates to low molecular weight heparins (LMWHs) and very low molecular weight heparins (VLMWHs) in the treatment of chronic ulcers, particularly of diabetic foot ulcers, and more specifically in the manufacture of a medicinal product for the treatment of chronic ulcers, and particularly diabetic foot ulcers and pressure ulcers.

摘要翻译： 本发明涉及用于治疗糖尿病足溃疡的糖胺聚糖组合物，其具体涉及用于治疗慢性溃疡，特别是糖尿病足溃疡的低分子量肝素（LMWH）和极低分子量肝素（VLMWH）），以及 更具体地涉及用于治疗慢性溃疡的药物的制造，特别是糖尿病足溃疡和压疮。