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1.发明申请PHARMACEUTICAL COMPOSITION WITH GLYCOSAMINOGLYCANS AND USE THEREOF IN THE TREATMENT OF CHRONIC ULCERS 审中-公开糖蛋白类药物的药物组合物及其在治疗慢性淋巴细胞白血病中的应用公开(公告)号：US20110201572A1
公开(公告)日：2011-08-18
申请号：US13001895
申请日：2009-06-30
IPC分类号： A61K31/727 , C08B37/10 , A61P17/02
CPC分类号： A61K31/727 , A61K9/0019 , A61K31/726 , A61K47/26 , A61K2300/00
摘要： The invention relates to a composition of glycosaminoglycans for the treatment of diabetic foot ulcer, it specifically relates to low molecular weight heparins (LMWHs) and very low molecular weight heparins (VLMWHs) in the treatment of chronic ulcers, particularly of diabetic foot ulcers, and more specifically in the manufacture of a medicinal product for the treatment of chronic ulcers, and particularly diabetic foot ulcers and pressure ulcers.
摘要翻译： 本发明涉及用于治疗糖尿病足溃疡的糖胺聚糖组合物，其具体涉及用于治疗慢性溃疡，特别是糖尿病足溃疡的低分子量肝素（LMWH）和极低分子量肝素（VLMWH）），以及 更具体地涉及用于治疗慢性溃疡的药物的制造，特别是糖尿病足溃疡和压疮。
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2.发明授权公开(公告)号：US08822659B2
公开(公告)日：2014-09-02
申请号：US13122981
申请日：2009-10-02
摘要： Procedure for the synthesis of deprotected pentasaccharides from a protected precursor pentasaccharide through a reaction procedure having five stages whereamong is included an N-sulphation of amino groups and a hydrogenolysis of benzyl groups. Through this procedure a drastic reduction is achieved in the total synthesis time in comparison with the process traditionally employed, together with increased reproducibility thereof, permitting the standardization thereof.
摘要翻译： 通过具有五个阶段的反应程序从被保护的前体五糖合成去保护的五糖的方法包括氨基的N-硫酸化和苄基的氢解。 通过该方法，与传统使用的方法相比，在总合成时间中实现了显着的减少，同时具有增加的再现性，允许其标准化。
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公开(公告)号：US08257744B2
公开(公告)日：2012-09-04
申请号：US12779556
申请日：2010-05-13
CPC分类号： A61K9/1635 , A61K9/1647 , A61K9/5138 , A61K9/5153
摘要： Pharmaceutical form containing at least an active compound and a polymeric matrix, wherein said polymeric matrix comprises at least one polymer of cationic nature and at least one biodegradable polymer, process for the preparation thereof, pharmaceutical formulations comprising said pharmaceutical form, and their uses. The pharmaceutical form provides enhanced absorption of active compounds across the mucosa.
摘要翻译： 含有至少一种活性化合物和聚合物基质的药物形式，其中所述聚合物基质包含至少一种具有阳离子性质的聚合物和至少一种可生物降解聚合物，其制备方法，包含所述药物形式的药物制剂及其用途。 药物形式提供活性化合物在粘膜上的增强的吸收。
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4.发明申请PROCESS FOR THE SYNTHESIS OF UNPROTECTED PENTASACCHARIDES FROM A PROTECTED PENTASACCHARIDE PRECURSOR 有权未经保护的PENTASACCHARIDES从保护的PENTASACCHARIDE前体合成的方法公开(公告)号：US20110306757A1
公开(公告)日：2011-12-15
申请号：US13122981
申请日：2009-10-02
IPC分类号： C07H15/04
摘要： Procedure for the synthesis of deprotected pentasaccharides from a protected precursor pentasaccharide through a reaction procedure having five stages whereamong is included an N-sulphation of amino groups and a hydrogenolysis of benzyl groups. Through this procedure a drastic reduction is achieved in the total synthesis time in comparison with the process traditionally employed, together with increased reproducibility thereof, permitting the standardisation thereof.
摘要翻译： 通过具有五个阶段的反应程序从被保护的前体五糖合成去保护的五糖的方法包括氨基的N-硫酸化和苄基的氢解。 通过该方法，与传统使用的方法相比，在总合成时间中实现了显着的减少，同时具有增加的再现性，允许其标准化。
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