公开(公告)号：US08445667B2

公开(公告)日：2013-05-21

申请号：US13531657

申请日：2012-06-25

申请人： Anastasia Khvorova ,  Angela Reynolds ,  Devin Leake ,  William Marshall ,  Steven Read ,  Stephen Scaringe

发明人： Anastasia Khvorova ,  Angela Reynolds ,  Devin Leake ,  William Marshall ,  Steven Read ,  Stephen Scaringe

IPC分类号： C07H21/04 ,  C07H21/02

CPC分类号： C07H21/02 ,  A61K31/713 ,  C07H21/00 ,  C12N15/111 ,  C12N15/113 ,  C12N15/1135 ,  C12N15/1136 ,  C12N15/1137 ,  C12N15/1138 ,  C12N2310/14 ,  C12N2320/10 ,  C12N2320/11 ,  C12N2330/30 ,  C12Y304/21047 ,  G06F19/18

摘要： Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed including those directed to nucleotide sequences for CDKN1B.

摘要翻译： 通过使用siRNA技术，有效的序列特异性基因沉默是可能的。 通过合理设计选择特定的siRNA，可以最大限度地产生有效的基因沉默试剂，以及沉默基因的方法。 公开了通过合理设计siRNA产生的方法，组合物和试剂盒，包括针对CDKN1B的核苷酸序列的那些。

公开(公告)号：US08268985B2

公开(公告)日：2012-09-18

申请号：US12924078

申请日：2010-09-20

申请人： Anastasia Khvorova ,  Angela Reynolds ,  Devin Leake ,  William Marshall ,  Steven Read ,  Stephen Scaringe

发明人： Anastasia Khvorova ,  Angela Reynolds ,  Devin Leake ,  William Marshall ,  Steven Read ,  Stephen Scaringe

IPC分类号： C07H21/04

CPC分类号： C12N15/113 ,  C12N15/111 ,  C12N15/1135 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2320/11 ,  G06F19/18

摘要： Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed including those directed to nucleotide sequences for APP.

摘要翻译： 通过使用siRNA技术，有效的序列特异性基因沉默是可能的。 通过合理设计选择特定的siRNA，可以最大限度地产生有效的基因沉默试剂，以及沉默基因的方法。 公开了通过合理设计siRNA产生的方法，组合物和试剂盒，包括针对APP的核苷酸序列的那些。

公开(公告)号：US08222396B2

公开(公告)日：2012-07-17

申请号：US12807526

申请日：2010-09-08

申请人： Anastasia Khvorova ,  Angela Reynolds ,  Devin Leake ,  William Marshall ,  Steven Read ,  Stephen Scaringe

发明人： Anastasia Khvorova ,  Angela Reynolds ,  Devin Leake ,  William Marshall ,  Steven Read ,  Stephen Scaringe

IPC分类号： C07H21/04

CPC分类号： C12N15/113 ,  C12N15/111 ,  C12N15/1135 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2320/11 ,  G06F19/18

摘要： Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed including those directed to nucleotide sequences for MET.

摘要翻译： 通过使用siRNA技术，有效的序列特异性基因沉默是可能的。 通过合理设计选择特定的siRNA，可以最大限度地产生有效的基因沉默试剂，以及沉默基因的方法。 公开了通过合理设计siRNA产生的方法，组合物和试剂盒，包括针对MET的核苷酸序列的那些。

公开(公告)号：US08222395B2

公开(公告)日：2012-07-17

申请号：US12584352

申请日：2009-09-03

申请人： Anastasia Khvorova ,  Angela Reynolds ,  Devin Leake ,  William Marshall ,  Steven Read ,  Stephen Scaringe

发明人： Anastasia Khvorova ,  Angela Reynolds ,  Devin Leake ,  William Marshall ,  Steven Read ,  Stephen Scaringe

IPC分类号： C07H21/02 ,  C07H21/04 ,  A61K31/70 ,  C12Q1/68

CPC分类号： C12N15/113 ,  C12N15/111 ,  C12N15/1135 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2320/11 ,  G06F19/18

摘要： Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed including those directed to nucleotide sequences for KDR.

摘要翻译： 通过使用siRNA技术，有效的序列特异性基因沉默是可能的。 通过合理设计选择特定的siRNA，可以最大限度地产生有效的基因沉默试剂，以及沉默基因的方法。 公开了通过合理设计siRNA产生的方法，组合物和试剂盒，包括针对KDR的核苷酸序列的那些。

公开(公告)号：US11759452B2

公开(公告)日：2023-09-19

申请号：US17314107

申请日：2021-05-07

申请人： PSILERA INC.

发明人： Christopher G. Witowski ,  Jacqueline L. Salm

IPC分类号： A61K31/4045 ,  C07D209/16 ,  A61K31/48 ,  A61K31/675 ,  A61K31/55 ,  A61K31/405 ,  A61K9/00 ,  A61K9/70 ,  A61K9/06 ,  A61K9/20

CPC分类号： A61K31/4045 ,  A61K9/0043 ,  A61K9/06 ,  A61K9/2009 ,  A61K9/2013 ,  A61K9/2018 ,  A61K9/2027 ,  A61K9/2054 ,  A61K9/7061 ,  A61K9/7069 ,  A61K31/405 ,  A61K31/48 ,  A61K31/55 ,  A61K31/675 ,  C07D209/16

摘要： Pharmaceutical formulations of novel indole compounds and psilocybin analogs are manufactured, provided in novel oral, transdermal, and nasal pharmaceutical compositions for use to treat neurological, mood or abuse diseases and disorders.

公开(公告)号：US11406394B2

公开(公告)日：2022-08-09

申请号：US16363824

申请日：2019-03-25

申请人： Christopher Strattner

发明人： Christopher Strattner

IPC分类号： A61B17/132 ,  B43K29/00

摘要： A tourniquet windlass device is provided with a writing functionality. The device may be designed such that it may be used with an improvised constricting band such as a necktie or other fabric.

公开(公告)号：USD947498S1

公开(公告)日：2022-04-05

申请号：US29662493

申请日：2018-09-06

申请人： Cowboys of the Sky Original Work Pants, LLC

设计人： Lynette Burkley ,  Clark Myers

公开(公告)号：US10548982B2

公开(公告)日：2020-02-04

申请号：US16198134

申请日：2018-11-21

申请人： UCL BUSINESS PLC

发明人： Mark Smith ,  Stephen Caddick ,  James Baker ,  Vijay Chudasama

IPC分类号： A61K47/60 ,  A61K47/62 ,  A61K47/54 ,  C07K14/655 ,  C07D207/14 ,  C07D207/456 ,  C07D209/52 ,  G01N33/58 ,  A61K49/00 ,  A61K47/55 ,  C07D207/416 ,  C07K14/435

摘要： The present invention relates to the use of a compound containing a moiety of formula (I) as a reagent for linking a compound of formula R1—H which comprises a first functional moiety of formula F1 to a second functional moiety of formula F2 wherein X, X′, Y, R1, F1 and F2 are as defined herein. The present invention also provides related processes and products. The present invention is useful for creating functional conjugate compounds, and specifically conjugates in which at least one of the constituent molecules carries a thiol group.

公开(公告)号：US10278709B2

公开(公告)日：2019-05-07

申请号：US15185653

申请日：2016-06-17

申请人： Christopher Strattner

发明人： Christopher Strattner

IPC分类号： A61B17/132 ,  B43K29/00

摘要： A tourniquet windlass device is provided with a writing functionality. The device may be designed such that it may be used with an improvised constricting band such as a necktie or other fabric.

公开(公告)号：US10029067B2

公开(公告)日：2018-07-24

申请号：US15550200

申请日：2016-08-15

申请人： Brain State Technologies, LLC

发明人： Lee Gerdes ,  Peter Gerdes ,  Russell Loucks ,  Paul Hastings ,  Gillan Smith ,  Sung Lee

IPC分类号： A61M21/00 ,  A61B5/048 ,  A61B5/04 ,  A61B5/00 ,  A61B5/0478

摘要： Exposure to stressors may be associated with the production of asymmetry in brain waves and can significantly affect a person's overall degree of wellbeing and conversely, asymmetry may influence a person's experience of stress. Through devices and methods that simultaneously look for asymmetries and in real time, one can create real time variable sequences of acoustical stimuli, and then one can effectively and efficiently support the brain to balance its activity between corresponding right and left lobes without one's mindful attention. Additionally various devices and methods can be used to identify condition states, including stress state conditions.