公开(公告)号：US20130237520A1

公开(公告)日：2013-09-12

申请号：US13868967

申请日：2013-04-23

Applicant: GILEAD CONNECTICUT, INC.

Inventor： Scott A. MITCHELL ,  Kevin S. CURRIE ,  Peter A. BLOMGREN ,  Jeffrey E. KROPF ,  Seung H. LEE ,  Jianjun XU ,  Douglas G. STAFFORD ,  James P. HARDING ,  Antonio J.M. BARBOSA, JR. ,  Zhongdong ZHAO ,  David M. ARMISTEAD ,  Soumya MITRA

IPC: C07D487/04 ,  C12Q1/48 ,  C07D498/04

CPC classification number: C07D487/04 ,  A61K31/495 ,  C07D471/04 ,  C07D491/107 ,  C07D498/04 ,  C07D519/00 ,  C12Q1/485 ,  G01N33/573 ,  G01N2333/91205

Abstract: Certain imidazopyrazines and pharmaceutical compositions thereof are provided herein. Methods of treating patients suffering from certain diseases and disorders responsive to the inhibition of Syk activity, which comprises administering to such patients an amount of at least one chemical entity effective to reduce signs or symptoms of the disease or disorder are provided. Also provided are methods for determining the presence or absence of Syk kinase in a sample.

公开(公告)号：US20130231330A1

公开(公告)日：2013-09-05

申请号：US13862147

申请日：2013-04-12

Applicant: GILEAD CONNECTICUT, INC.

Inventor： Scott A. MITCHELL ,  Kevin S. CURRIE ,  Peter A. BLOMGREN ,  Jeffrey E. KROPF ,  Seung H. LEE ,  Jianjun XU ,  Douglas G. STAFFORD

IPC: C07D487/04 ,  C07D519/00

CPC classification number: C07D519/00 ,  A61K9/0053 ,  C07D471/04 ,  C07D487/04 ,  G01N2333/9121

Abstract: Certain imidazopyrazines and pharmaceutical compositions thereof are provided herein. Methods of treating patients suffering from certain diseases and disorders responsive to the inhibition of Syk activity, which comprises administering to such patients an amount of at least one chemical entity effective to reduce signs or symptoms of the disease or disorder are provided. Also provided are methods for determining the presence or absence of Syk kinase in a sample.