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公开(公告)号：US20220098551A1
公开(公告)日：2022-03-31
申请号：US17547863
申请日：2021-12-10
Inventor： Benjamin Eithan REUBINOFF , Orna SINGER
Abstract: A method of generating retinal pigment epithelial (RPE) cells is disclosed. The method comprises: (a) culturing human pluripotent stem cells in a human feeder cell-conditioned medium to obtain a cultured population of human pluripotent stem cells; (b) culturing said cultured population of human pluripotent stem cells in a medium comprising a differentiating agent to obtain differentiating cells; and (c) culturing said differentiating cells in a medium comprising one or more members of the TGFβ superfamily.
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公开(公告)号：US20220064730A1
公开(公告)日：2022-03-03
申请号：US17528699
申请日：2021-11-17
Applicant: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. , HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD.
Inventor： Yuval DOR , Ruth SHEMER , Benjamin GLASER
IPC: C12Q1/6881 , C12Q1/6886 , C12Q1/6883
Abstract: A method of detecting death of a cell type or tissue in a subject is disclosed. The method comprises determining whether cell-free DNA comprised in a fluid sample of the subject is derived from the cell type or tissue, wherein the determining is effected by ascertaining the methylation status of at least four methylation sites on a continuous sequence of the cell-free DNA, the sequence comprising no more than 300 nucleotides, wherein a methylation status of each of the at least four methylation sites on the continuous sequence of the DNA characteristic of the cell type or tissue is indicative of death of the cell type or tissue. Kits for detecting cell death are also disclosed.
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公开(公告)号：US20210395237A1
公开(公告)日：2021-12-23
申请号：US17334905
申请日：2021-05-31
Applicant: HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD. , RAMOT AT TEL-AVIV UNIVERSITY LTD.
Inventor： Or KAKHLON , Miguel Enrique WEIL , Leonardo Javier SOLMESKY
IPC: C07D409/12 , A61P25/28 , C07D487/08
Abstract: Compounds represented by general Formulae I to IV as described herein are disclosed. Further disclosed are composition utilizing the herein disclosed compounds and using the same for the treatment of glycogen storage disorders.
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公开(公告)号：US11203784B2
公开(公告)日：2021-12-21
申请号：US15303762
申请日：2015-04-14
Applicant: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. , Hadasit Medical Research Services and Development Ltd.
Inventor： Yuval Dor , Ruth Shemer , Benjamin Glaser
IPC: C07H21/04 , C12Q1/68 , C12Q1/6881 , C12Q1/6886 , C12Q1/6883
Abstract: A method of detecting death of a cell type or tissue in a subject is disclosed. The method comprises determining whether cell-free DNA comprised in a fluid sample of the subject is derived from the cell type or tissue, wherein the determining is effected by ascertaining the methylation status of at least four methylation sites on a continuous sequence of the cell-free DNA, the sequence comprising no more than 300 nucleotides, wherein a methylation status of each of the at least four methylation sites on the continuous sequence of the DNA characteristic of the cell type or tissue is indicative of death of the cell type or tissue. Kits for detecting cell death are also disclosed.
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公开(公告)号：US11035857B2
公开(公告)日：2021-06-15
申请号：US15470926
申请日：2017-03-28
Inventor： Benjamin Eithan Reubinoff , Nurit Yachimovich-Cohen , Limor Matzrafi
Abstract: A method of selecting retinal pigmented epithelial (RPE) cells from a mixed population of cells is disclosed. The method comprises: (a) analyzing the cells of the mixed population of cells for at least one of the following parameters: (i) cells which autofluorescence above a predetermined threshold; (ii) cells which express CD81 above a predetermined threshold; and (iii) cells which scatter light perpendicular to a laser beam above a predetermined threshold; and (b) selecting cells which are positive for at least one of the parameters, thereby sorting RPE cells from a mixed population of cells.
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Patent Agency Ranking
公开(公告)号：US10933031B2
公开(公告)日：2021-03-02
申请号：US16068251
申请日：2017-01-06
Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK , HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD. , RAMOT AT TEL-AVIV UNIVERSITY LTD.
Inventor： Hasan Orhan Akman , Salvatore Dimauro , Or Kakhlon , Miguel Enrique Weil
IPC: A61K31/085 , A61K31/05 , A61P3/08 , A61K9/00 , G01N33/53
Abstract: The current invention is a method of preventing and treating certain diseases by preventing the synthesis and/or breakdown of glycogen by the administration of an agent, guaiacol. Diseases that can be prevented and treated by the administration of guaiacol include but are not limited to glycogen storage disease type IV (GSD-IV), adult polyglucosan body disease (APBD), and Lafora disease (LD). The invention also includes methods and tools for screening for agents that prevent and treat these diseases as well as basic research, specifically in the form of cells and cell lines that produce detectable polyglucosan.
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公开(公告)号：US20210007589A1
公开(公告)日：2021-01-14
申请号：US16937209
申请日：2020-07-23
Applicant: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. , Hadasit Medical Research Services and Development Ltd.
Inventor： Itai Hayut , Elchanan Fried , Yaakov Nahmias , Tommy Weiss-Sadan , Ariel Shrem
Abstract: A guided tracheal intubation system using an autonomous modulated light source, outputting modulated illumination at a constant level, and externally applied to the subject's larynx region. An optical imaging system receives a video stream from within the subject's throat, including modulated illumination from the subject's trachea. A display control system performs signal processing on the modulated content of the images, and outputs frames of those images in which the intensity level of illumination from the trachea can be controlled without any need to change the illumination output from the modulated light source. The light source has no connection with the rest of the system, and need contain no more than a battery, a power supply circuit and a light source. It can therefore be of low cost and can be made disposable, such as in the form of an adhesive patch applied to the subject's neck.
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公开(公告)号：US20210000839A1
公开(公告)日：2021-01-07
申请号：US17026593
申请日：2020-09-21
Inventor： Dana WOLF
IPC: A61K31/541 , A61K31/7056 , A61K31/517 , A61K31/675 , A61K31/522 , A61P31/12
Abstract: The present invention provides compositions and methods for treating, preventing, and inhibiting viral replication, viral infections and viral diseases and disorders, comprising use of artemisone in combination with at least one antiviral compound selected from maribavir, cidofovir, brincidofovir, valganciclovir, and letermovir, and the combination provides a synergistic anti-viral effect. The invention also provides compositions and methods for treating, preventing, and inhibiting viral replication, viral infections and viral diseases and disorders, comprising the use of artemisone in combination with ganciclovir, wherein the molar ratio between artemisone and ganciclovir is about 1:100 to 100:1, and the combination provides a synergistic anti-viral effect. Pharmaceutical compositions comprising artemisone and at least one of said antiviral compounds are provided as well.
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公开(公告)号：US20200330210A1
公开(公告)日：2020-10-22
申请号：US16643061
申请日：2018-08-28
Applicant: HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD. , AZRIELI COLLEGE OF ENGINEERING JERUSALEM
Inventor： Yoav MINTZ , Nikolai KUNICHER , Tali TAVOR RE'EM
IPC: A61F2/00 , A61K31/734 , A61K33/14 , A61L31/04
Abstract: Disclosed herein are devices/kits and methods for reducing, treating, preventing or eliminating post-operative adhesions in an intervention/target site within a body of a subject. The method comprises the steps of: introducing an applicator, configured for applying an anti-adhesive composition, into an intervention/target site within a body of a subject; applying the anti-adhesive composition onto the intervention/target site; and extracting the applicator from the body of the subject, wherein the method is performed during or following an interventional procedure.
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50.发明申请公开(公告)号：US20200172970A1
公开(公告)日：2020-06-04
申请号：US16630593
申请日：2018-07-13
Applicant: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , Hadasit medical research services and development ltd.
Inventor： Yuval DOR , Ruth SHEMER , Benjamin GLASER , Judith MAGENHEIM
IPC: C12Q1/6876 , C12Q1/6827 , C12Q1/686 , C12Q1/6869
Abstract: A digital droplet PCR method of analyzing the methylation status of methylation sites of a double-stranded DNA molecule which comprises at least two methylation sites per single strand of the double-stranded DNA molecule is disclosed.
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