公开(公告)号：US20200377478A1

公开(公告)日：2020-12-03

申请号：US16996516

申请日：2020-08-18

申请人： Newave Pharmaceutical Inc.

发明人： Yi Chen

IPC分类号： C07D403/04 ,  A61P35/04

摘要： The disclosure includes compounds of Formula (I), wherein Q1, Q2, Q3, W, X, Y, Z1, m, n, Warhead, R1, R2, R3, R4, and R5, are defined herein. Also disclosed is a method for treating a neoplastic disease, autoimmune disease, and inflammatory disorder with these compounds.

公开(公告)号：US20190169182A1

公开(公告)日：2019-06-06

申请号：US16269824

申请日：2019-02-07

申请人： Newave Pharmaceutical Inc.

发明人： Yi Chen ,  Yan Lou

IPC分类号： C07D455/06 ,  C07D471/04 ,  A61P31/20 ,  C07D498/04

摘要： The disclosure includes compounds of Formula (I) wherein Z1, Z2, Z3, X, R1, R2, R3, R4, R5, R6, and R7 are defined herein. Also disclosed is a method for treating HBV infection.

公开(公告)号：US10253029B2

公开(公告)日：2019-04-09

申请号：US15645067

申请日：2017-07-10

申请人： Newave Pharmaceutical Inc.

发明人： Yi Chen ,  Yan Lou

IPC分类号： A61K31/519 ,  C07D487/04 ,  C07D471/04 ,  C07D239/48 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14

摘要： The disclosure includes compounds of Formula (I) wherein Warhead1, Warhead2, R3, R4, R5, R6, R7, R8, Q, A, B, p, q, Z1, Z2, Z3, and Z4 are defined herein. Also disclosed is a method for treating a neoplastic disease with these compounds.

公开(公告)号：US20190040062A1

公开(公告)日：2019-02-07

申请号：US16045736

申请日：2018-07-26

申请人： Newave Pharmaceutical Inc.

发明人： Yi Chen ,  Yan Lou

IPC分类号： C07D471/14 ,  A61P35/00 ,  A61P35/02

CPC分类号： C07D471/14 ,  A61P35/00 ,  A61P35/02

摘要： The disclosure includes compounds of Formula (I) wherein W, R1, R2, R3, R4, R5, R6, m, n, L, and Z1, are defined herein. Also disclosed is a method for treating a neoplastic disease and autoimmune disease with these compounds.