公开(公告)号：US20240166646A1

公开(公告)日：2024-05-23

申请号：US18268632

申请日：2021-12-20

申请人： Newave Pharmaceutical Inc.

发明人： Yi Chen

IPC分类号： C07D471/04 ,  A61P35/02 ,  C07D498/04 ,  C07D498/14

CPC分类号： C07D471/04 ,  A61P35/02 ,  C07D498/04 ,  C07D498/14

摘要： The present invention relates to compounds of e.g. formula (I) as BCL-2 inhibitors for the treatment of neoplastic, autoimmune or neurodegenerative diseases. Preferred compounds are e.g. fused 1H-pyrrolo[2,3-b]pyridine derivatives of e.g. formula (II)

公开(公告)号：US20240058457A1

公开(公告)日：2024-02-22

申请号：US18268359

申请日：2021-12-17

申请人： Newave Pharmaceutical Inc.

发明人： Yi Chen

IPC分类号： A61K47/55 ,  A61P35/00 ,  A61P29/00

CPC分类号： A61K47/55 ,  A61P35/00 ,  A61P29/00

摘要： The disclosure includes compounds of any one of Formulae (0)-(5), (A)-(E), (1)-(V), (11)-(20), as described herein. Also disclosed is a method for treating a neoplastic disease, autoimmune disease, and inflammatory disorder with these compounds.

公开(公告)号：US20230271979A1

公开(公告)日：2023-08-31

申请号：US18142842

申请日：2023-05-03

申请人： Newave Pharmaceutical Inc.

发明人： Yi Chen ,  Yan Lou

IPC分类号： C07D498/14 ,  A61P35/02 ,  A61P35/04 ,  A61P35/00 ,  A61K31/5383 ,  A61K31/542 ,  A61K45/06 ,  C07D513/14 ,  A61P37/00

CPC分类号： C07D498/14 ,  A61P35/02 ,  A61P35/04 ,  A61P35/00 ,  A61K31/5383 ,  A61K31/542 ,  A61K45/06 ,  C07D513/14 ,  A61P37/00

摘要： The disclosure includes compounds of Formula (A):




wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, and R12, j, k, m, n, Y, W, W1, W2, W3, V, L, Z1, Q1, Q2, Q3, and Q4, are defined herein. Also disclosed is a method for treating a neoplastic disease, an autoimmune disease, or a neorodegenerative disease with these compounds.

公开(公告)号：US11501284B2

公开(公告)日：2022-11-15

申请号：US16996516

申请日：2020-08-18

申请人： Newave Pharmaceutical Inc.

发明人： Yi Chen

IPC分类号： A61K31/497 ,  C07D241/20 ,  G06Q20/34 ,  G06K19/07 ,  A61P35/04 ,  C07D403/04

摘要： The disclosure includes compounds of Formula (I) wherein Q1, Q2, Q3, W, X, Y, Z1, m, n, Warhead, R1, R2, R3, R4, and R5, are defined herein. Also disclosed is a method for treating a neoplastic disease, autoimmune disease, and inflammatory disorder with these compounds.

公开(公告)号：US11279711B2

公开(公告)日：2022-03-22

申请号：US16795884

申请日：2020-02-20

申请人： Newave Pharmaceutical Inc.

发明人： Yi Chen ,  Yan Lou

IPC分类号： C07D498/14 ,  C07D513/14 ,  A61P35/00 ,  A61P37/00 ,  A61P35/02 ,  A61P35/04 ,  A61K31/5383 ,  A61K31/542 ,  A61K45/06

摘要： The disclosure includes compounds of Formula (A): wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, and R12, j, k, m, n, Y, W, W1, W2, W3, V, L, Z1, Q1, Q2, Q3, and Q4, are defined herein. Also disclosed is a method for treating a neoplastic disease, an autoimmune disease, or a neorodegenerative disease with these compounds.

公开(公告)号：US20200071329A1

公开(公告)日：2020-03-05

申请号：US16529228

申请日：2019-08-01

申请人： Newave Pharmaceutical Inc.

发明人： Yi Chen ,  Yan Lou

IPC分类号： C07D471/14 ,  A61P35/02 ,  A61P35/00

摘要： The disclosure includes compounds of Formula (I) wherein W, R1, R2, R3, R4, R5, R6, m, n, L, and Z1, are defined herein. Also disclosed is a method for treating a neoplastic disease and autoimmune disease with these compounds.

公开(公告)号：US10377755B2

公开(公告)日：2019-08-13

申请号：US16045736

申请日：2018-07-26

申请人： Newave Pharmaceutical Inc.

发明人： Yi Chen ,  Yan Lou

IPC分类号： C07D471/14 ,  A61P35/02 ,  A61P35/00

摘要： The disclosure includes compounds of Formula (I) wherein W, R1, R2, R3, R4, R5, R6, m, n, L, and Z1, are defined herein. Also disclosed is a method for treating a neoplastic disease and autoimmune disease with these compounds.

公开(公告)号：US11680072B2

公开(公告)日：2023-06-20

申请号：US17698289

申请日：2022-03-18

申请人： Newave Pharmaceutical Inc.

发明人： Yi Chen ,  Yan Lou

IPC分类号： C07D498/14 ,  A61P35/02 ,  A61P35/04 ,  A61P35/00 ,  A61K31/5383 ,  A61K31/542 ,  A61K45/06 ,  C07D513/14 ,  A61P37/00

CPC分类号： C07D498/14 ,  A61K31/5383 ,  A61K31/542 ,  A61K45/06 ,  A61P35/00 ,  A61P35/02 ,  A61P35/04 ,  A61P37/00 ,  C07D513/14

摘要： The disclosure includes compounds of Formula (A):




wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, and R12, j, k, m, n, Y, W, W1, W2, W3, V, L, Z1, Q1, Q2, Q3, and Q4, are defined herein. Also disclosed is a method for treating a neoplastic disease, an autoimmune disease, or a neurodegenerative disease with these compounds.

公开(公告)号：US20220402941A1

公开(公告)日：2022-12-22

申请号：US17840957

申请日：2022-06-15

申请人： Newave Pharmaceutical Inc.

发明人： Yi Chen ,  Yan Lou

IPC分类号： C07D498/14 ,  A61P35/02 ,  A61P35/04 ,  A61P35/00 ,  A61K31/5383 ,  A61K31/542 ,  A61K45/06 ,  C07D513/14 ,  A61P37/00

摘要： The disclosure includes compounds of Formula (A): wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, and R12, j, k, m, n, Y, W, W1, W2, W3, V, L, Z1, Q1, Q2, Q3, and Q4, are defined herein. Also disclosed is a method for treating a neoplastic disease, an autoimmune disease, or a neorodegenerative disease with these compounds.

公开(公告)号：US20220363689A1

公开(公告)日：2022-11-17

申请号：US17764329

申请日：2020-08-20

申请人： Newave Pharmaceutical Inc. ,  GUANGZHOU LUPENG PHARMACEUTICAL COMPANY LTD.

发明人： Yi Chen

IPC分类号： C07D495/04 ,  A61P35/00

摘要： The disclosure includes compounds of Formula (I) wherein Q0, Q1, Q2, Q3, Q4, Z, W, i, j, m, n, Warhead, R0, R1, R3, R4, R5, R6, and R7, are defined herein. Also disclosed is a method for treating a neoplastic disease, autoimmune disease, and inflammatory disorder with these compounds.