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公开(公告)号：US20170298045A1
公开(公告)日：2017-10-19
申请号：US15638279
申请日：2017-06-29
发明人： Giovanni Cianchetta , Byron DeLaBarre , Janeta Popovici-Muller , Francesco G. Salituro , Jeffrey O. Saunders , Jeremy Travins , Shunqi Yan , Tao Guo , Li Zhang
IPC分类号： C07D401/14 , C07D417/04 , C07D413/14 , C07D413/12 , C07D413/04 , C07D405/14 , C07D405/12 , C07D403/04 , C07D401/12 , C07D251/18 , A61K31/5377 , C07D493/08 , A61K31/53
CPC分类号： C07D401/14 , A61K31/53 , A61K31/5377 , C07D251/18 , C07D401/12 , C07D403/04 , C07D405/12 , C07D405/14 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D493/08
摘要： Provided are compounds useful for treating cancer and methods of treating cancer comprising administering to a subject in need thereof a compound described herein.
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公开(公告)号：US20170283401A1
公开(公告)日：2017-10-05
申请号：US15488174
申请日：2017-04-14
IPC分类号： C07D405/14 , C07D403/04 , C07D409/04 , C07D401/04 , C07D417/04
CPC分类号： C07D405/14 , C07D401/04 , C07D403/04 , C07D409/04 , C07D417/04
摘要： Compositions comprising compounds that modulate pyruvate kinase M2 (PKM2) are described herein. Also described herein are methods of using the compounds that modulate PKM2 in the treatment of cancer.
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公开(公告)号：US20160304556A1
公开(公告)日：2016-10-20
申请号：US15196842
申请日：2016-06-29
发明人： Janeta Popovici-Muller , Jeffrey O. Saunders , Francesco G. Salituro , Zhenwei Cai , Ding Zhou , Shunqi Yan
CPC分类号： C07K5/06078 , A61K38/05 , A61K45/06 , C07D205/04 , C07D207/16 , C07D207/48 , C07D209/42 , C07D213/56 , C07D213/74 , C07D215/48 , C07D233/61 , C07D233/64 , C07D233/68 , C07D233/90 , C07D241/04 , C07D249/04 , C07D249/08 , C07D257/04 , C07D263/04 , C07D263/06 , C07D263/24 , C07D265/30 , C07D401/04 , C07D403/04 , C07D403/12 , C07D413/12 , C07D471/04 , C07K5/0202 , C07K5/06026 , C07K5/0606 , C07K5/06069 , C07K5/06139 , C07K5/06165 , C07K5/06191
摘要： Provided are methods of treating a cancer characterized by the presence of a mutant allele of IDH1/2 comprising administering to a subject in need thereof a compound described here.
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