公开(公告)号：US3644436A

公开(公告)日：1972-02-22

申请号：US3644436D

申请日：1969-04-30

Applicant: AMERICAN HOME PROD

Inventor： WENDT GERHARD R ,  LEDIG KURT W ,  TELLER DANIEL M

IPC: C07J41/00 ,  C07C169/00

CPC classification number: C07J41/0005

Abstract: THE DISCLOSURE IS DIRECTED TO BIS(AMIDINOHYDRAZONES) OF GONA-3,17-DINORPREGNA-3,20-DIONES. THE COMPOUNDS HAVE DARDIOTONIC ACTIVITY.

公开(公告)号：US3642842A

公开(公告)日：1972-02-15

申请号：US3642842D

申请日：1968-12-23

Applicant: AMERICAN HOME PROD

Inventor： BEGANY ALBERT J ,  LEDIG KURT W ,  OLIVER DONALD W ,  WENDT GERHARD R

IPC: C07J41/00 ,  C07J63/00 ,  C07C169/20

CPC classification number: C07J63/008 ,  C07J41/0005

Abstract: 13-ALKYL-17X-SUBSTITUTED - 17 - HYDROXYGON-4-EN-3-ONE, SEMICARBAXONES AND THIOSEMICARBAZONES, $4,6,8(14),9 AND 11 DEHYDRO ANALOGS, AND D-HOMO ANALOGS THEREOF, OPTIONALLY SUBSTITUTED BY METHYL AT POSTIONS 1,2,4,6,7 AND 11, ALKANOYL AT POSTION 17, BY ALKYL, ARYL, ARYLALKYL AND ALKYLARYL IN THE SEMICARBAZONE OR THIOSEMICARBAZONE GROUP, AND BY A 17X-ALKYL GROUP OR BY METHYL OR HAOLGEN IN A 17X-ETHYNYL GROUP (I) ARE PROVIDED BY CONDENSING THE CORRESPONDING 3-KETOSTEROID (II) WITH THE CORRESPONDING SEMICARBAZIDE OR THIOSEMICARBAZIDE (III). COMPOUNDS (I) ARE PHARMACOLOGICALLY ACTIVE IN WARM BLOODED LOWER ANIMALS AS BRONOCHODILATORS AND AS ANTI-INFLAMMATORY AGENTS.

公开(公告)号：US3577445A

公开(公告)日：1971-05-04

申请号：US3577445D

申请日：1968-12-23

Applicant: AMERICAN HOME PROD

Inventor： OLIVER DONALD W ,  WENDT GERHARD R

IPC: C07C169/08

CPC classification number: C07J75/00

Abstract: NOVEL 19-NORSTEROIDAL 3-CHLORO-3,5-DIENES, PARTICULARLY, 3-CHLORO-13-ETHYL-17A-ETHYNYL(OR CHLOROETHYNYL)GONA-3,5DIEN-17-OLS (I) ARE PROVIDED BY CHLORO/ENOLIZING THE CORRESPONDING GON-4-EN-3-ONES (II) WITH A REAGENT SUCH AS OXALYL CHLORIDE. COMPOUNDS I ARE PHARMACOLOGICALLY ACTIVE AS BRONOCHODILATORS AND BIOCIDALLY-ACITVE, AS BACTERICIDES.

公开(公告)号：US3553213A

公开(公告)日：1971-01-05

申请号：US3553213D

申请日：1969-03-17

Applicant: AMERICAN HOME PROD

Inventor： OLIVER DONALD W ,  WENDT GERHARD R

IPC: C07J41/00 ,  C07J43/00 ,  C07J75/00 ,  C07C173/10

CPC classification number: C07J43/00 ,  C07J41/00 ,  C07J75/00

Abstract: 13 - ALKYL - 17A - AMINOALKYNYL - 3 - CHLOROGONA - 3,5DIEN-17-OLS AND 17-ALKANOATES (1) AND THEIR SALTS ARE USEFUL AS TRICHOMONACIDES, FUNGICIDES, AMEBICIDES AND BACTERICIDES. COMPOUNDS (I) ARE PREPARED BY TREATING THE CORRESPONDING 13 - ALKYL - 3 - CHLORO - 17A - ETHYNLGONA-3,5DIEN-17-OL OR 17-ALKANOTE (II) WITH FORMALDEHYDE AND AN APPROPRIATELY-SUBSTITUTED SECONDARY AMINE.

公开(公告)号：US3431262A

公开(公告)日：1969-03-04

申请号：US3431262D

申请日：1968-03-26

Applicant: AMERICAN HOME PROD

Inventor： WENDT GERHARD R ,  LEDIG KURT W

IPC: C07D487/04 ,  C07D51/78 ,  C07D57/24

CPC classification number: C07D487/04 ,  Y10S514/87

公开(公告)号：US3394150A

公开(公告)日：1968-07-23

申请号：US55974166

申请日：1966-06-23

Applicant: AMERICAN HOME PROD

Inventor： WENDT GERHARD R

IPC: C07J41/00

CPC classification number: C07J41/0072 ,  Y10S514/929

公开(公告)号：US3317597A

公开(公告)日：1967-05-02

申请号：US53731766

申请日：1966-03-25

Applicant: AMERICAN HOME PROD

Inventor： WENDT GERHARD R ,  LEDIG KURT W

CPC classification number: A61K31/175

公开(公告)号：US3299064A

公开(公告)日：1967-01-17

申请号：US53383366

申请日：1966-03-14

Applicant: AMERICAN HOME PROD

Inventor： WENDT GERHARD R ,  LEDIG KURT W

IPC: C07D471/04

CPC classification number: C07D471/04

公开(公告)号：US3280185A

公开(公告)日：1966-10-18

申请号：US49227365

申请日：1965-10-01

Applicant: AMERICAN HOME PROD

Inventor： WENDT GERHARD R ,  LEDIG KURT W

CPC classification number: A61K31/175

公开(公告)号：US3272849A

公开(公告)日：1966-09-13

申请号：US49230465

申请日：1965-10-01

Applicant: AMERICAN HOME PROD

Inventor： WENDT GERHARD R ,  LEDIG KURT W

IPC: C07J1/00 ,  C07J75/00

CPC classification number: C07J1/00 ,  C07J75/00