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公开(公告)号:US20190216790A1
公开(公告)日:2019-07-18
申请号:US16336424
申请日:2017-10-12
IPC分类号: A61K31/4462 , A61P17/04 , A61K9/00 , A61K31/17 , A61P17/06
CPC分类号: A61K31/4462 , A61K9/0019 , A61K31/05 , A61K31/165 , A61K31/17 , A61K31/175 , A61K31/19 , A61K31/341 , A61K31/495 , A61P17/04 , A61P17/06
摘要: The present disclosure provides compositions and methods for treating chronic itch.
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公开(公告)号:US20180042935A1
公开(公告)日:2018-02-15
申请号:US15789476
申请日:2017-10-20
发明人: Gerard M. Housey
IPC分类号: A61K31/5377 , C07D403/12 , C07D253/075 , C07D215/38 , C07D213/86 , C07D213/77 , C07C243/38 , A61K31/444 , A61K31/415 , A61K31/4196 , A61K31/44 , A61K31/4436 , A61K31/517 , A61K31/495 , A61K31/166 , A61K31/175 , A61K31/195 , A61K31/27 , A61K31/4709 , A61K31/505 , A61K31/506 , A61K31/53 , G01N33/50 , A61K31/47 , G01N33/574 , C07D409/12 , C07D405/12 , C07D401/12 , C07D253/065 , C07D239/84 , C07D239/48 , C07D239/42 , C07D231/14 , C07D215/50 , C07D213/87 , G01N33/573 , C07D213/81
CPC分类号: A61K31/5377 , A61K31/166 , A61K31/175 , A61K31/195 , A61K31/27 , A61K31/415 , A61K31/4196 , A61K31/44 , A61K31/4436 , A61K31/444 , A61K31/47 , A61K31/4709 , A61K31/495 , A61K31/505 , A61K31/506 , A61K31/517 , A61K31/53 , C07C243/38 , C07D213/77 , C07D213/81 , C07D213/86 , C07D213/87 , C07D215/38 , C07D215/50 , C07D231/14 , C07D239/42 , C07D239/48 , C07D239/84 , C07D253/065 , C07D253/075 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , G01N33/5011 , G01N33/502 , G01N33/5041 , G01N33/573 , G01N33/574 , G01N2500/00 , G01N2500/10
摘要: This invention relates to agents that are inhibitors or activators of variant forms of endogenous proteins and novel methods of identifying such variants. Of particular interest are inhibitors and activators of endogenous protein variants, encoded by genes which have mutated, which variants often arise or are at least first identified as having arisen following exposure to a chemical agent which is known to be an inhibitor or activator of the corresponding unmutated endogenous protein.
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公开(公告)号:US20180002280A1
公开(公告)日:2018-01-04
申请号:US15545968
申请日:2016-01-27
申请人: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY , THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK
发明人: David J. Augeri , Anthony F. Bencivenga , Adam Blanden , Darren R. Carpizo , John A. Gilleran , Spencer David Kimball , Stewart N. Loh , Xin Yu
IPC分类号: C07C337/08 , C07D401/14 , C07D401/12 , C07D213/53 , C07D205/04 , C07C281/08 , A61K31/397 , C07D403/12 , A61K31/175
CPC分类号: C07C337/08 , A61K31/175 , A61K31/397 , C07C281/08 , C07D205/04 , C07D213/53 , C07D213/68 , C07D401/12 , C07D401/14 , C07D403/12
摘要: The invention provides compounds of formula I and II and salts thereof, wherein R1, R2, Y, R3, and R4 have any of the meanings described in the specification, as well as compositions comprising such compounds and salts, and methods for treating cancer using such compounds and salts.
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4.
公开(公告)号:US20180002279A1
公开(公告)日:2018-01-04
申请号:US15545966
申请日:2016-01-27
申请人: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY , THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK
发明人: David J. Augeri , Anthony F. Bencivenga , Adam Blanden , Darren R. Carpizo , John A. Gilleran , Spencer David Kimball , Stewart N. Loh , Xin Yu
IPC分类号: C07C337/08 , C07D213/53 , C07C281/08 , A61K31/175 , A61K31/397 , A61K31/315 , C07D401/12 , C07D205/04
CPC分类号: C07C337/08 , A61K31/175 , A61K31/315 , A61K31/397 , C07C281/08 , C07D205/04 , C07D213/53 , C07D401/12
摘要: The invention provides organic complexes of Zn2+ of formula (I) that are useful for treating cancer, as well as compositions and kits comprising such complexes, and intermediate monomer compounds that are useful for the preparation of such complexes.
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公开(公告)号:US20170304244A1
公开(公告)日:2017-10-26
申请号:US15520100
申请日:2014-10-24
发明人: Joung Han Yim , Il-Chan Kim , Se Jong Han , Dong-Gyu Jo
IPC分类号: A61K31/198
CPC分类号: A61K31/198 , A61K31/167 , A61K31/17 , A61K31/175
摘要: The present invention relates to a neurodegenerative disease treatment use, which is a novel use of Ramalin, and, more specifically, to a composition for preventing or treating neurodegenerative diseases, containing Ramalin, which has an inflammasome and BACE1 expression inhibitory activity. Ramalin according to the present invention has an effect of improving a cognitive ability by inhibiting the expression of an inflammatory factor, which contains an NLRP inflammasome protein, and BACE1, and is thus useful for preventing or treating memory disorder and neurodegenerative diseases.
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6.
公开(公告)号:US20170273926A1
公开(公告)日:2017-09-28
申请号:US15218149
申请日:2016-07-25
发明人: Victor A. LEVIN
IPC分类号: A61K31/198 , A61K31/475 , A61K31/166 , A61K9/00 , A61K31/17
CPC分类号: A61K31/198 , A61K9/0019 , A61K9/0053 , A61K31/166 , A61K31/17 , A61K31/175 , A61K31/475 , A61K45/06 , A61P35/00 , A61K2300/00
摘要: Eflornithine is an agent that can be used to treat glioma, especially glioma of WHO Grade II or Grade III such as anaplastic glioma. Eflornithine can suppress or prevent mutations in glioma which can cause the glioma to progress to a higher grade. Compositions and methods can include eflornithine or a derivative or analog of eflornithine, together with other agents such as conventional anti-neoplastic agents for treatment of glioma, inhibitors of polyamine transport, polyamine analogs, or S-adenosylmethionine decarboxylase inhibitors.
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公开(公告)号:US09540317B2
公开(公告)日:2017-01-10
申请号:US14271170
申请日:2014-05-06
发明人: Ralph Mazitschek , James E. Bradner
IPC分类号: A61K38/05 , C07C243/38 , A61K31/175 , A61K31/495 , C12Q1/48 , A61K45/06 , C07D239/42 , C07D401/04
CPC分类号: C07C243/38 , A61K31/175 , A61K31/495 , A61K38/05 , A61K45/06 , C07D239/42 , C07D401/04 , C12Q1/48
摘要: The present invention is drawn to compounds of Formula (I) below: and the pharmaceutically acceptable salts thereof, wherein R and R″ are defined herein. The compounds are useful inhibitors of histone deacetylases (HDAC).
摘要翻译: 如本文所述的通式(I)和(II)的HDAC抑制剂及其药学上可接受的盐可用作组蛋白脱乙酰酶或其它脱乙酰酶的抑制剂,因此可用于治疗与乙酰酶/ 如本文所述的脱乙酰酶活性(例如,癌症)。 在某些实施方案中,本发明的化合物选择性地靶向HDAC家族的类别或同种型。 本发明的另一方面提供了一种用于测定测试化合物对HDAC蛋白质的抑制作用的测定法,包括:在测试化合物存在下,将HDAC蛋白质与通式(IIIc)的底物一起培养; 并测定HDAC蛋白的活性。
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公开(公告)号:US09518098B2
公开(公告)日:2016-12-13
申请号:US14128882
申请日:2012-06-25
申请人: Ariel Ruiz Altaba
发明人: Ariel Ruiz Altaba
IPC分类号: C07K19/00 , C07H21/02 , C07K14/435 , A61K31/7105 , A61K31/166 , A61K31/175 , A61K31/495 , A61K31/7088 , A61K38/12 , A61K38/17 , A61K39/395
CPC分类号: C07K14/435 , A61K31/166 , A61K31/175 , A61K31/495 , A61K31/7088 , A61K31/7105 , A61K38/12 , A61K38/17 , A61K39/39533
摘要: The present invention relates to substances and compositions thereof useful in the control of cancer stem cell persistence and concomitant tumor recurrence and/or control of tumor growth. In particular, the invention relates to substances and compositions useful in the treatment of cancers and/or tumors linked to cancer stem cells, preferably brain cancers and/or tumors, in a subject.
摘要翻译: 本发明涉及可用于控制癌症干细胞持久性和伴随的肿瘤复发和/或控制肿瘤生长的物质及其组合物。 特别地,本发明涉及可用于治疗与受试者中的癌症干细胞,优选脑癌和/或肿瘤连接的癌症和/或肿瘤的物质和组合物。
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公开(公告)号:US09474748B2
公开(公告)日:2016-10-25
申请号:US14159753
申请日:2014-01-21
发明人: Rheal A. Towner , Robert A. Floyd
IPC分类号: A61K31/15 , A61K31/185 , A61K31/4748 , A23L1/30 , A61K45/06 , A61K31/166 , A61K31/175
CPC分类号: A61K31/15 , A23L33/10 , A61K31/166 , A61K31/175 , A61K31/185 , A61K31/4748 , A61K45/06 , A61N5/10 , A61K2300/00
摘要: The present invention involves the use of 2,4-disulfonyl phenyl tert-butyl nitrone (2,4-ds-PBN) in the treatment and prevention of gliomas. The 2,4-ds-PBN may be used alone or combined with other traditional chemo- and radiotherapies and surgery, to treat or prevent glioma occurrence, recurrence, spread, growth, metastasis, or vascularization.
摘要翻译: 本发明涉及2,4-二磺酰苯基叔丁基硝酮(2,4-ds-PBN)在治疗和预防胶质瘤中的用途。 2,4-ds-PBN可以单独使用或与其他传统化学和放射治疗和手术组合使用,以治疗或预防胶质瘤发生,复发,扩散,生长,转移或血管化。
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公开(公告)号:US09464041B2
公开(公告)日:2016-10-11
申请号:US14271503
申请日:2014-05-07
IPC分类号: A01N47/10 , A01N33/02 , A01N33/18 , A01N33/24 , A61K31/27 , A61K31/135 , A61K31/04 , C07C271/20 , A61K31/137 , A61K31/175 , A61K45/06
CPC分类号: A61K31/27 , A61K31/137 , A61K31/175 , A61K45/06 , C07C271/20 , A61K2300/00
摘要: The present invention relates to the use of compounds of the invention for treatment and/or prevention of fatigue, including fatigue associated with diseases or treatments.
摘要翻译: 本发明涉及本发明化合物用于治疗和/或预防疲劳的用途,包括与疾病或治疗有关的疲劳。
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