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公开(公告)号：US08326429B2
公开(公告)日：2012-12-04
申请号：US13088223
申请日：2011-04-15
IPC分类号： A61N1/08
CPC分类号： A61B5/04001 , A61B5/4047 , A61B5/4818 , A61B5/4866 , A61B5/7264 , A61N1/36117 , A61N1/365 , A61N1/3702
摘要： An exemplary includes acquiring an electroneurogram of the right carotid sinus nerve or the left carotid sinus nerve, analyzing the electroneurogram for at least one of chemosensory information and barosensory information and calling for one or more therapeutic actions based at least in part on the analyzing. Therapeutic actions may aim to treat conditions such as sleep apnea, an increase in metabolic demand, hypoglycemia, hypertension, renal failure, and congestive heart failure. Other exemplary methods, devices, systems, etc., are also disclosed.
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公开(公告)号：US20120184867A1
公开(公告)日：2012-07-19
申请号：US13432923
申请日：2012-03-28
IPC分类号： A61B5/0452 , A61B5/0432
CPC分类号： A61B5/0452 , A61B5/4842 , A61B5/686 , A61N1/365
摘要： Specific embodiments provided herein relate to diagnosing, with improved specificity, occurrences of episodes relating to disorders that are known to affect T-wave morphology. One or more propensity metric is obtained, each of which is indicative of a patient's propensity for a specific disorder that is known to affect T-wave morphology. T-wave variability is monitored. Additionally, there is monitoring for a specific change in T-wave morphology that is known to be indicative of episodes relating to a disorder. When the specific change in T-wave morphology is detected, a diagnosis is determined for detecting the specific change in T-wave morphology, taking into account the propensity metric(s) and the T-wave variability.
摘要翻译： 本文提供的具体实施方案涉及具有改善的特异性诊断与已知影响T波形态的病症相关的发作的发生。 获得一个或多个倾向度量，每个倾向度量指示患者对已知影响T波形态的特定病症的倾向。 监测T波变化。 另外，监测T波形态的具体变化已知是指示与病症相关的发作。 当检测到T波形态的具体变化时，考虑到倾向度量和T波变异性，确定检测T波形态的具体变化的诊断。
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公开(公告)号：US20110270105A1
公开(公告)日：2011-11-03
申请号：US13088232
申请日：2011-04-15
IPC分类号： A61B5/0402
CPC分类号： A61B5/0452 , A61B5/0464 , A61B5/7257
摘要： Embodiments of the present invention relate to implantable systems, and methods for use therewith, for monitoring myocardial electrical stability. A patient's heart is paced for a period of time using a patterned pacing sequence that repeats every N beats, and an electrical signal is obtained that is representative of a plurality of consecutive beats of the patient's heart while it is being paced using the patterned pacing sequence that repeats every N beats. Myocardial electrical stability is then analyzed using time domain techniques that are tailored to the patterned pacing sequence used to pace the patient's heart. In other embodiments, the patient's heart need not be paced. This abstract is not intended to be a complete description of, or limit the scope of, the invention.
摘要翻译： 本发明的实施例涉及用于监测心肌电稳定性的可植入系统及其使用的方法。 患者的心脏使用重复每N次跳动的图案化起搏序列来起搏一段时间，并且获得代表患者心脏的多个连续搏动的电信号，同时使用图案化的起搏序列进行起搏 重复每N次跳动。 然后使用针对用于调节患者心脏的图案化起搏序列定制的时域技术来分析心肌电稳定性。 在其他实施例中，患者的心脏不需要起搏。 本摘要不是对本发明的完整描述或限制本发明的范围。
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公开(公告)号：US20110202105A1
公开(公告)日：2011-08-18
申请号：US13018140
申请日：2011-01-31
申请人： Naixiong Jiang , Gene A. Bornzin , John W. Poore , Sheldon Williams , Weiqun Yang , Taraneh Ghaffari Farazi
发明人： Naixiong Jiang , Gene A. Bornzin , John W. Poore , Sheldon Williams , Weiqun Yang , Taraneh Ghaffari Farazi
CPC分类号： A61N1/378 , H01M2/0275 , H01M2/1066 , H01M2/1653 , H01M2/18 , H01M2/361 , H01M4/12 , H01M4/366 , H01M4/48
摘要： A bioelectric battery may be used to power implantable devices. The bioelectric battery may have an anode electrode and a cathode electrode separated by an insulating member comprising a tube having a first end and a second end, wherein said anode is inserted into said first end of said tube and said cathode surrounds said tube such that the tube provides a support for the cathode electrode. The bioelectric battery may also have a membrane surrounding the cathode to reduce tissue encapsulation. Alternatively, an anode electrode, a cathode electrode surrounding the cathode electrode, a permeable membrane surrounding the cathode electrode. An electrolyte is disposed within the permeable membrane and a mesh surrounds the permeable membrane. In an alternative embodiment, a pacemaker housing acts as a cathode electrode for a bioelectric battery and an anode electrode is attached to the housing with an insulative adhesive.
摘要翻译： 生物电池可用于为可植入装置供电。 生物电池可以具有由包括具有第一端和第二端的管的绝缘构件分开的阳极电极和阴极电极，其中所述阳极插入所述管的所述第一端，所述阴极围绕所述管，使得 管为阴极提供支撑。 生物电池还可以具有围绕阴极的膜以减少组织包封。 或者，阳极电极，围绕阴极电极的阴极电极，围绕阴极电极的可渗透膜。 电解质设置在可渗透膜内，并且网围绕可渗透膜。 在替代实施例中，起搏器壳体用作生物电池的阴极电极，并且阳极通过绝缘粘合剂附接到壳体。
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45.发明授权公开(公告)号：US07970473B2
公开(公告)日：2011-06-28
申请号：US12244607
申请日：2008-10-02
IPC分类号： A61N1/00
CPC分类号： A61B5/046 , A61B5/04011 , A61B5/0464 , A61N1/3702 , A61N1/3956
摘要： Methods and systems are provided for performing ventricular arrhythmia monitoring using at least two sensing channels that are each associated with different sensing vectors, for example by different pairs of extracardiac remote sensing electrodes. Myopotential associated with each of the sensing channels in monitored, and a ventricular arrhythmia monitoring mode is selected based thereon (e.g., based on determined myopotential levels). Ventricular arrhythmia monitoring is then performed using the selected monitoring mode.
摘要翻译： 提供的方法和系统用于使用至少两个感测通道进行心室心律失常监测，每个感测通道各自与不同的感测向量相关联，例如通过不同的心外感测电极对。 与监测的每个感测通道相关联的神经电位和基于（例如，基于确定的电位电平）来选择心室心律失常监测模式。 然后使用所选择的监测模式进行室性心律失常监测。
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公开(公告)号：US07949399B2
公开(公告)日：2011-05-24
申请号：US12915991
申请日：2010-10-29
IPC分类号： A61N1/08
CPC分类号： A61N1/36114 , A61B5/04001 , A61B5/4047 , A61B5/7264 , A61N1/36117 , A61N1/36514 , A61N1/36557 , A61N1/36564
摘要： An exemplary includes acquiring an electroneurogram of the right carotid sinus nerve or the left carotid sinus nerve, analyzing the electroneurogram for at least one of chemosensory information and barosensory information and calling for one or more therapeutic actions based at least in part on the analyzing. Therapeutic actions may aim to treat conditions such as sleep apnea, an increase in metabolic demand, hypoglycemia, hypertension, renal failure, and congestive heart failure. Other exemplary methods, devices, systems, etc., are also disclosed.
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公开(公告)号：US07949390B1
公开(公告)日：2011-05-24
申请号：US11354629
申请日：2006-02-14
IPC分类号： A61B5/02
CPC分类号： A61B5/0452 , A61B5/0464 , A61B5/7257
摘要： Embodiments of the present invention relate to implantable systems, and methods for use therewith, for monitoring myocardial electrical stability. A patient's heart is paced for a period of time using a patterned pacing sequence that repeats every N beats, and an electrical signal is obtained that is representative of a plurality of consecutive beats of the patient's heart while it is being paced using the patterned pacing sequence that repeats every N beats. Myocardial electrical stability is then analyzed using time domain techniques that are tailored to the patterned pacing sequence used to pace the patient's heart. In other embodiments, the patient's heart need not be paced. This abstract is not intended to be a complete description of, or limit the scope of, the invention.
摘要翻译： 本发明的实施例涉及用于监测心肌电稳定性的可植入系统及其使用的方法。 患者的心脏使用重复每N次跳动的图案化起搏序列来起搏一段时间，并且获得代表患者心脏的多个连续搏动的电信号，同时使用图案化的起搏序列进行起搏 重复每N次跳动。 然后使用针对用于调节患者心脏的图案化起搏序列定制的时域技术来分析心肌电稳定性。 在其他实施例中，患者的心脏不需要起搏。 本摘要不是对本发明的完整描述或限制本发明的范围。
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公开(公告)号：US07920913B1
公开(公告)日：2011-04-05
申请号：US11771514
申请日：2007-06-29
IPC分类号： A61B5/04
CPC分类号： A61B5/14551 , A61B2560/02
摘要： Provided herein are implantable systems, and methods for use therewith, that increase the accuracy of measurements produced using an implanted sensor, where the measurements are affected by cycles of a cyclical body function (e.g., heart beat and/or respiration). In accordance with specific embodiments of system, a measurement that is presumed to be accurate is obtained. The measurement can be of a physiologic property, such as, but not limited to, blood oxygen saturation, hematocrit, or blood glucose concentration. Additionally, the implanted is used to produce a plurality of measurements of the physiologic property. Such measurements, produced using the implanted sensor, are compared to the measurement presumed to be accurate to thereby identify when the measurements produced using the implanted sensor are most accurate. Thereafter, the implanted system is configured to use the implanted sensor to produce measurements when the measurements produced using the implanted sensor are most accurate.
摘要翻译： 本文提供了可植入系统及其使用的方法，其增加使用植入式传感器产生的测量的精度，其中测量受周期性身体功能（例如心跳和/或呼吸）的周期的影响。 根据系统的具体实施例，获得推测为准确的测量值。 测量可以具有生理特性，例如但不限于血氧饱和度，血细胞比容或血糖浓度。 另外，植入用于产生生理特性的多个测量。 将使用植入的传感器产生的这种测量与推定为准确的测量进行比较，从而识别何时使用植入的传感器产生的测量是最准确的。 此后，当使用植入的传感器产生的测量最准确时，植入系统被配置为使用植入的传感器来产生测量。
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公开(公告)号：US07881792B1
公开(公告)日：2011-02-01
申请号：US11229410
申请日：2005-09-16
IPC分类号： A61N1/362 , A61B5/0452
CPC分类号： A61B5/0452 , A61N1/36114 , A61N1/365
摘要： Embodiments of the present invention relate to implantable systems, and method for use therein, that can detect T-wave alternans. In accordance with specific embodiments of the present invention, intrinsic premature contractions of the ventricles are detected, and at least one metric of T-waves is measured in a specified number of beats that follow each detected intrinsic premature contraction of the ventricles. A determination of whether T-wave alternans are present is made based on the measured T-wave metrics. In alternative embodiments, rather than waiting for intrinsic premature contractions of the ventricles, premature contractions of the ventricles are caused on demand by inducing premature atrial contractions. In still other embodiments, a patient's vagus nerve is stimulated to simulate premature contractions of the ventricles. This abstract is not intended to be a complete description of, or limit the scope of, the invention.
摘要翻译： 本发明的实施例涉及可以检测T波交替的可植入系统及其中使用的方法。 根据本发明的具体实施例，检测到心室的内在的早期收缩，并且在每个检测到的心室的内在过早收缩之后，以规定数量的搏动来测量至少一个T波的度量。 基于测量的T波量度来确定是否存在T波交替。 在替代实施例中，不是等待心室的内在过早收缩，通过诱导早产性心房收缩，根据需要引起心室的过早收缩。 在其他实施例中，刺激患者的迷走神经以模拟心室的过早收缩。 本摘要不是对本发明的完整描述或限制本发明的范围。
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50.发明授权System and method of using vagal stimulation to assess autonomic tone and risk of sudden cardiac death in an implantable cardiac device 有权使用迷走神经刺激来评估植入式心脏装置中心脏猝死的自主神经紧张和风险的系统和方法公开(公告)号：US07869870B1
公开(公告)日：2011-01-11
申请号：US10861747
申请日：2004-06-04
IPC分类号： A61N1/362
CPC分类号： A61B5/0402 , A61B5/6846 , A61N1/36114 , A61N1/36592
摘要： A method and apparatus for using vagal stimulation to detect autonomic tone and assess a patient's risk of sudden cardiac death (SCD) are presented. The method involves stimulating the patient's vagus nerve in order to induce a drop in arterial blood pressure, which simulates the patient's cardiovascular response to a premature ventricular contraction (PVC). Sinus rhythm data just before and immediately following the stimulation is recorded and analyzed for a degree of heart rate turbulence (HRT) in order to detect abnormalities in autonomic tone and assess the risk of SCD. In an embodiment, the method is implemented in an implantable cardiac device (ICD), which can deliver arrhythmia prevention therapy based on the risk of SCD. The method can assess the patient's vagal activity on-demand by measuring HRT without relying on naturally occurring PVCs and eliminates the risk of causing arrhythmia associated with artificially inducing PVCs in order to measure HRT.
摘要翻译： 提出了一种使用迷走神经刺激来检测自主神经紧张度并评估患者心源性猝死风险（SCD）的方法和装置。 该方法涉及刺激患者的迷走神经以诱导动脉血压下降，其模拟患者对早搏性心室收缩（PVC）的心血管反应。 记录并紧随刺激后的窦性心律数据并分析心率湍动程度（HRT），以检测自主神经张力异常并评估SCD的风险。 在一个实施例中，该方法在可植入心脏装置（ICD）中实现，其可以基于SCD的风险来递送心律失常预防疗法。 该方法可以通过测量HRT来评估患者的迷走神经活动，而不依赖于天然存在的PVC，并消除与人工诱导PVC相关的心律不齐的风险以测量HRT。
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