公开(公告)号：US20220389101A1

公开(公告)日：2022-12-08

申请号：US17739940

申请日：2022-05-09

Applicant: GENMAB A/S

Inventor： Rik RADEMAKER ,  Isil ALTINTAS ,  Patrick ENGELBERTS ,  Janine SCHUURMAN ,  Paul PARREN

IPC: C07K16/28 ,  C07K16/32

Abstract: The present invention relates to humanized or chimeric antibodies binding CD3. It furthermore relates to bispecific antibodies, compositions, pharmaceutical compositions, use of said antibodies in the treatment of a disease, and method of treatment.

公开(公告)号：US20210324105A1

公开(公告)日：2021-10-21

申请号：US17149019

申请日：2021-01-14

Applicant: GENMAB A/S

Inventor： Bart DE GOEIJ ,  Patrick VAN BERKEL ,  Kristin STRUMANE ,  Aran Frank LABRIJN ,  Joost J. NEIJSSEN ,  Joyce I. MEESTERS ,  Paul PARREN ,  Janine SCHUURMAN

IPC: C07K16/32 ,  C07K16/28 ,  C07K16/10 ,  C07K16/46 ,  A61K47/68 ,  A61K39/395 ,  A61K45/06

Abstract: Bispecific antibodies which comprise antigen-binding regions binding to two different epitopes of human epidermal growth factor receptor 2 (HER2), and related antibody-based compositions and molecules, are disclosed. Pharmaceutical compositions comprising the antibodies and methods of preparing and using the antibodies are also disclosed.

公开(公告)号：US20210155699A1

公开(公告)日：2021-05-27

申请号：US17099328

申请日：2020-11-16

Applicant: Genmab A/S

Inventor： Aran Frank LABRIJN ,  Stefan LOVERIX ,  Paul PARREN ,  Jan VAN DE WINKEL ,  Janine SCHUURMAN ,  Ignace LASTERS

IPC: C07K16/28 ,  C07K16/00 ,  A61K39/395 ,  A61K51/10 ,  A61K47/68

Abstract: The present invention relates to positions in the constant region of antibodies, in particular the CH3 region of IgG4, which affect the strength of CH3-CH3 interactions. Mutations that either stabilize or destabilize this interaction are disclosed.

公开(公告)号：US20200332022A1

公开(公告)日：2020-10-22

申请号：US16783720

申请日：2020-02-06

Applicant: GENMAB A/S

Inventor： Aran Frank LABRIJN ,  Joyce I. MEESTERS ,  Joost J. NEIJSSEN ,  Edward Norbert VAN DEN BRINK ,  Janine SCHUURMAN ,  Paul PARREN

IPC: C07K16/40 ,  C07K16/28 ,  C07K16/10 ,  C07K16/36 ,  C07K16/00 ,  C07K16/32 ,  C07K16/12

Abstract: Described herein are, proteins comprising amino acid substitutions in at least one of a first and a second polypeptide chain. Furthermore, is described the uses and methods related to said proteins.

公开(公告)号：US20190169298A1

公开(公告)日：2019-06-06

申请号：US16183300

申请日：2018-11-07

Applicant: GENMAB A/S

Inventor： Paul PARREN ,  Janine SCHUURMAN ,  Tom VINK ,  Willem Karel BLEEKER ,  Jan VAN DE WINKEL ,  Patrick VAN BERKEL ,  Frank BEURSKENS

IPC: C07K16/28

Abstract: The present invention provides monovalent antibodies with a long half-life when administered in vivo, methods of making such monovalent antibodies, pharmaceutical compositions comprising such antibodies, and uses of the monovalent antibodies.

公开(公告)号：US20170313782A1

公开(公告)日：2017-11-02

申请号：US15484583

申请日：2017-04-11

Applicant: GENMAB A/S

Inventor： Joost J. NEIJSSEN ,  Bart DE GOEIJ ,  Edward Norbert VAN DEN BRINK ,  Aran Frank LABRIJN ,  Rene HOET ,  Janine SCHUURMAN ,  Paul PARREN ,  Jan VAN DE WINKEL

IPC: C07K16/30 ,  A61K45/06 ,  C07K16/40 ,  A61K39/395 ,  G01N33/574 ,  C07K16/28 ,  A61K39/00

Abstract: Isolated monoclonal antibodies which bind to human c-Met, the hepatocyte growth factor receptor, and related antibody-based compositions and molecules, are disclosed. Pharmaceutical compositions comprising the antibodies and therapeutic and diagnostic methods for using the antibodies are also disclosed.

公开(公告)号：US20160159930A1

公开(公告)日：2016-06-09

申请号：US14934956

申请日：2015-11-06

Applicant: GENMAB A/S

Inventor： Janine SCHUURMAN ,  Tom VINK ,  Jan VAN DE WINKEL ,  Aran Frank LABRIJN ,  Rob AALBERSE ,  Marijn VAN DER NEUT KOLFSCHOTE ,  Paul PARREN

IPC: C07K16/46 ,  C07K16/28

CPC classification number: C07K16/468 ,  C07K16/00 ,  C07K16/2863 ,  C07K16/2887 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/526 ,  C07K2317/53 ,  C07K2319/00

Abstract: The invention relates to an ex vivo method for the generation of a bispecific antibody, comprising the steps of: a) providing a first antibody having a first binding specificity, wherein said first antibody comprises an IgG4-like CH3 region, b) providing a second antibody having a second binding specificity which differs from said first binding specificity, wherein said second antibody comprises an IgG4-like CH3 region, c) incubating said first and second antibodies together under reducing conditions which allow the cysteines in the core hinge region to undergo disulfide-bond isomerization, and d) obtaining a bispecific antibody. The invention furthermore relates to bispecific antibodies obtainable by the method of the invention.

Abstract translation: 本发明涉及用于产生双特异性抗体的离体方法，包括以下步骤：a）提供具有第一结合特异性的第一抗体，其中所述第一抗体包含IgG4样CH3区，b）提供第二抗体 具有不同于所述第一结合特异性的第二结合特异性的抗体，其中所述第二抗体包含IgG4样CH3区，c）在还原条件下将所述第一抗体和第二抗体一起温育，所述还原条件允许核心铰链区中的半胱氨酸经历二硫键 并且d）获得双特异性抗体。 本发明还涉及通过本发明的方法可获得的双特异性抗体。

公开(公告)号：US20150329642A1

公开(公告)日：2015-11-19

申请号：US14721709

申请日：2015-05-26

Applicant: GENMAB A/S

Inventor： Joost J. NEIJSSEN ,  Bart DE GOEIJ ,  Edward Norbert VAN DEN BRINK ,  Aran Frank LABRIJN ,  Rene HOET ,  Janine SCHUURMAN ,  Paul PARREN ,  Jan VAN DE WINKEL

IPC: C07K16/30 ,  G01N33/574

CPC classification number: C07K16/3076 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C07K16/2863 ,  C07K16/40 ,  C07K2317/21 ,  C07K2317/31 ,  C07K2317/35 ,  C07K2317/524 ,  C07K2317/526 ,  C07K2317/53 ,  C07K2317/565 ,  C07K2317/71 ,  C07K2317/74 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/5748 ,  G01N2333/912

Abstract: Isolated monoclonal antibodies which bind to human c-Met, the hepatocyte growth factor receptor, and related antibody-based compositions and molecules, are disclosed. Pharmaceutical compositions comprising the antibodies and therapeutic and diagnostic methods for using the antibodies are also disclosed.

Abstract translation: 公开了结合人c-Met，肝细胞生长因子受体以及相关的基于抗体的组合物和分子的分离的单克隆抗体。 还公开了包含抗体的药物组合物和使用抗体的治疗和诊断方法。