公开(公告)号：US07060725B2

公开(公告)日：2006-06-13

申请号：US10434387

申请日：2003-05-08

申请人： Ahmed Abdel-Magid ,  Cynthia Maryanoff ,  Steven Mehrman ,  Kirk Sorgi ,  Frank Villani ,  Cheryl Kordik ,  Allen B. Reitz ,  Bruce Maryanoff

发明人： Ahmed Abdel-Magid ,  Cynthia Maryanoff ,  Steven Mehrman ,  Kirk Sorgi ,  Frank Villani ,  Cheryl Kordik ,  Allen B. Reitz ,  Bruce Maryanoff

IPC分类号： C07D323/00 ,  A61K31/335

CPC分类号： C07H5/06 ,  C07H9/04

摘要： The present invention is directed to novel compounds of the formula (I) wherein X, R1, R2, R3, R4, R5 and R6 are as described in the specification, processes for the preparation of and pharmaceutical compositions comprising said derivatives. The compounds of the present invention are useful for the treatment of epilepsy. The invention is further directed to a process for the preparation of compounds of formula (XX), wherein X, R3, R4, R5 and R6 are as described in the specification.

摘要翻译： 本发明涉及新的式（I）化合物，其中X，R 1，R 2，R 3，R 2， > 4，R 5和R 6如说明书中所述，制备方法和包含所述衍生物的药物组合物。 本发明的化合物可用于治疗癫痫。 本发明还涉及一种制备式（ⅩⅩ）化合物的方法，其中X，R 3，R 4，R 5， >和R 6'如说明书中所述。

公开(公告)号：US20060058373A1

公开(公告)日：2006-03-16

申请号：US11265670

申请日：2005-11-02

申请人： Ahmed Abdel-Magid ,  Cynthia Maryanoff ,  Steven Mehrman ,  Allen Reitz ,  Bruce Maryanoff

发明人： Ahmed Abdel-Magid ,  Cynthia Maryanoff ,  Steven Mehrman ,  Allen Reitz ,  Bruce Maryanoff

IPC分类号： A61K31/255 ,  C07C311/45 ,  A61K31/695

CPC分类号： C07H5/06 ,  C07H9/04

摘要： The present invention is directed to novel compounds of the formula (I) wherein X, R1, R2, R3, R4, R5 and R6 are as described in the specification, processes for the preparation of and pharmaceutical compositions comprising said derivatives. The compounds of the present invention are useful for the treatment of epilepsy. The invention is further directed to a process for the preparation of compounds of formula (XX), wherein X, R3, R4, R5 and R6 are as described in the specification.

摘要翻译： 本发明涉及新的式（I）化合物，