公开(公告)号：US20220249773A1

公开(公告)日：2022-08-11

申请号：US17665165

申请日：2022-02-04

Applicant: Insulet Corporation

Inventor： Yibin ZHENG ,  Joon Bok LEE ,  Jason O'CONNOR

IPC: A61M5/172 ,  G16H20/17 ,  A61B5/145 ,  A61M5/142

Abstract: Disclosed are techniques, a system and devices that enable the setting of an upper boundary constraint that may be a multiple of a total daily dosage setting for a liquid drug being administered to a user to control a condition, such as type 1 or type 2 diabetes mellitus. An automatic drug delivery algorithm may be configured to obtain a glucose control metric. A controller executing the automatic drug delivery algorithm may ascertain, based on the glucose control metric, an upper boundary constraint for the liquid drug that limits an amount of a dose of the liquid drug that may be delivered by the automatic drug delivery system or components thereof.

公开(公告)号：US20220226576A1

公开(公告)日：2022-07-21

申请号：US17715589

申请日：2022-04-07

Applicant: INSULET CORPORATION

Inventor： Yibin ZHENG ,  Joon Bok LEE ,  Ashutosh ZADE ,  Jason O'CONNOR

IPC: A61M5/172 ,  G06F17/17

Abstract: Exemplary embodiments may address the problem of missing blood glucose concentration readings from a glucose monitor that transmits blood glucose concentration readings over a wireless connection due to problems with the wireless connection. In the exemplary embodiments, an automated insulin delivery (AID) device uses an estimate in place of a missing blood glucose concentration reading in determining a predicted future blood glucose concentration reading for a user. Thus, the AID device is able to operate normally in generating insulin delivery settings despite not receiving a current blood glucose concentration reading for a current cycle. There is no need to suspend delivery of insulin to the user due to the missing blood glucose concentration reading.

公开(公告)号：US20220199215A1

公开(公告)日：2022-06-23

申请号：US17555040

申请日：2021-12-17

Applicant: Insulet Corporation

Inventor： Matthew ALLES ,  Daniel MURRAY ,  Joon Bok LEE ,  Jason O'CONNOR

IPC: G16H20/13 ,  G08B21/24 ,  G08B25/00 ,  G08B5/22 ,  G06F3/04842

Abstract: Exemplary embodiments may enable a user to schedule medicament bolus deliveries, such as insulin boluses, for future dates and times. The exemplary embodiments may provide the ability to delay a scheduled medicament bolus delivery by short periods of time. The user may reschedule a scheduled medicament bolus delivery by entering a new date and/or time for the medicament bolus delivery. Still further, a user may cancel a scheduled medicament bolus delivery. In addition, exemplary embodiments may enable multiple medicament bolus deliveries to be viewed and managed.

公开(公告)号：US20210228804A1

公开(公告)日：2021-07-29

申请号：US17150461

申请日：2021-01-15

Applicant: Insulet Corporation

Inventor： Eric BENJAMIN ,  Joon Bok LEE ,  Yibin ZHENG ,  Jason O'CONNOR ,  Ashutosh ZADE

IPC: A61M5/172 ,  A61B5/145 ,  A61K38/28

Abstract: Disclosed are a device, system, methods and computer-readable medium products that provide techniques to implement functionality to receive information related to a meal and delivery of a meal bolus. The received information may be stored and utilized in the generation of insulin delivery profiles. An estimate a mealtime insulin need based on the generated insulin delivery profiles may be generated. A dose of insulin may be determined that satisfies an estimated mealtime insulin need based on the generated insulin delivery profiles. The determined dose of insulin may be output at a time corresponding to a mealtime.

公开(公告)号：US20210187196A1

公开(公告)日：2021-06-24

申请号：US17123369

申请日：2020-12-16

Applicant: INSULET CORPORATION

Inventor： Joon Bok LEE ,  Jason O'CONNOR ,  Yibin ZHENG

IPC: A61M5/172 ,  A61M5/142

Abstract: Disclosed are a device, system, methods and computer-readable medium products that provide techniques to implement functionality to receive blood glucose measurements over a period of time. An average of missing blood glucose measurement values may be maintained over a predetermined time period. A count of a number of missing blood glucose measurement values over a period of time may be established. A controller may calculate a divergence of the number of missing blood glucose measurement values over the period of time from the average of missing blood glucose measurements over the predetermined time period. Based on a value of the divergence, a determination that a safety constraint for delivery of insulin is to be reduced. The safety constraint may be reduced by a predetermined percentage. An instruction to deliver an insulin dosage may be generated according to the reduced safety constraint may be forwarded to a wearable drug delivery device.

公开(公告)号：US20210077719A1

公开(公告)日：2021-03-18

申请号：US16570125

申请日：2019-09-13

Applicant: Insulet Corporation

Inventor： Steven CARDINALI ,  Joon Bok LEE ,  Jason O'CONNOR ,  Yibin ZHENG

IPC: A61M5/172 ,  A61B5/145 ,  G16H20/17 ,  G16H10/60

Abstract: Disclosed are a system, methods and computer-readable medium products that provide bolus dosage calculations by a control algorithm-based drug delivery system that provides automatic delivery of a drug, such as insulin or the like, based on sensor input. Blood glucose measurement values may be received at regular time intervals from a sensor. Using the blood glucose measurements, the control algorithm may perform various calculations and determinations to provide an appropriate bolus dosage. The appropriate bolus dosage may be used to respond to a trend in a trajectory of blood glucose measurements. In addition, a bolus dosage may also be determined by the disclosed device, system, method and/or computer-readable medium product in response to an indication that a user consumed a meal.

公开(公告)号：US20210038813A1

公开(公告)日：2021-02-11

申请号：US17079393

申请日：2020-10-23

Applicant: Insulet Corporation

Inventor： Jason O'CONNOR ,  Daniel ALLIS ,  David NAZZARO ,  John R. Bussiere ,  John D'ARCO

IPC: A61M5/172 ,  G16H40/63 ,  G16H20/17 ,  A61M5/142

Abstract: Systems and methods for automatically delivering medication to a user. An automated drug delivery system may include a sensor and a wearable automated drug delivery device. The wearable automated drug delivery device may be configured to couple to the skin of a user and may include a controller and a pump. The pump may be configured to output the medication. The controller may be within the wearable automated drug delivery device. The sensor may be coupled to the user and may be configured to collect information regarding the user. The controller of the wearable automated drug delivery device may use the collected information to locally determine an amount of medication to be output from the wearable automated drug delivery device and cause delivery of the amount of medication.

公开(公告)号：US20240269379A1

公开(公告)日：2024-08-15

申请号：US18643990

申请日：2024-04-23

Applicant: INSULET CORPORATION

Inventor： Jason O'CONNOR ,  Ian MCLAUGHLIN ,  Daniel ALLIS ,  David NAZZARO

IPC: A61M5/145 ,  A61M5/142 ,  A61M5/158 ,  A61M5/162 ,  A61M5/168

CPC classification number: A61M5/14566 ,  A61M5/14248 ,  A61M5/1582 ,  A61M5/162 ,  A61M5/16881 ,  A61M2005/14252 ,  A61M2205/3379 ,  A61M2205/583

Abstract: Disclosed are examples for a system for drug delivery and components thereof. The system may include an on-body pump device and a secondary unit. The on-body pump device may include a reservoir and a fluid pathway. The reservoir may be configured to hold a liquid drug. The secondary unit may be removably coupled to the on-body pump device. The secondary unit may be configured to receive a prefilled cartridge containing a liquid drug, expel the liquid drug from the prefilled cartridge, and deliver the liquid drug to the reservoir of the on-body pump device via the fluid pathway. Examples of variations to the secondary unit are also disclosed.

公开(公告)号：US20240165328A1

公开(公告)日：2024-05-23

申请号：US18422986

申请日：2024-01-25

Applicant: INSULET CORPORATION

Inventor： Joon Bok LEE ,  Yibin ZHENG ,  Jason O'CONNOR ,  Trang LY

IPC: A61M5/172 ,  A61B5/00 ,  A61B5/145 ,  A61M5/142 ,  G06Q30/0283 ,  G16H20/17

CPC classification number: A61M5/1723 ,  A61B5/14532 ,  A61B5/4839 ,  A61M5/142 ,  G06Q30/0283 ,  G16H20/17 ,  A61M2005/14208 ,  A61M2205/52 ,  A61M2230/201

Abstract: The exemplary embodiments provide medicament delivery devices that use cost functions in their control systems to determine medicament dosages. The cost function may have a medicament cost component and a performance cost component. The exemplary embodiments may use cost functions having medicament cost components that scale asymmetrically for different ranges of inputs (i.e., different candidate medicament dosages). The variance in scaling for different input ranges provides added flexibility to tailor the medicament cost component to the user and thus provide better management of medicament delivery to the user and better conformance to a performance target. The exemplary embodiments may use a cost function that has a medicament cost component (such as an insulin cost component) of zero for candidate dosages for a range of candidate dosages (e.g., below a reference dosage).

公开(公告)号：US20240100253A1

公开(公告)日：2024-03-28

申请号：US18466211

申请日：2023-09-13

Applicant: INSULET CORPORATION

Inventor： Joon Bok LEE ,  Yibin ZHENG ,  Jason O'CONNOR ,  Ashutosh ZADE

IPC: A61M5/172 ,  A61M5/142

CPC classification number: A61M5/1723 ,  A61M5/14244 ,  A61M2202/0486 ,  A61M2230/04 ,  A61M2230/40

Abstract: Disclosed are techniques, devices and systems that provide adjustments to parameter settings of an insulin delivery algorithm based on inputs from a number of generic sensor devices. A majority of the generic sensor devices provide sensor readings that are unused as inputs to a drug deliver algorithm. The generic sensor devices may be operable to detect characteristics, such as changes in a state of a user. A processor may evaluate a sensor reading provided by a particular sensor with respect to a sensor baseline reading for the particular sensor. Using the result of the evaluation, the processor may calculate an adjustment to a parameter setting or settings of a medication delivery algorithm. A dosage of medication may be modified based on the adjustment of the parameter setting or settings.