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公开(公告)号：US08057822B2
公开(公告)日：2011-11-15
申请号：US11174089
申请日：2005-06-30
CPC分类号： C07K14/605 , A61K47/60
摘要： Novel modified exendins and exendin agonists having an exendin or exendin agonist linked to one or more polyethylene glycol polymers, for example, and related formulations and dosages and methods of administration thereof are provided. These modified exendins and exendin agonists, compositions and methods are useful in treating diabetes and conditions that would be benefited by lowering plasma glucose or delaying and/or slowing gastric emptying or inhibiting food intake.
摘要翻译： 提供了具有与一种或多种聚乙二醇聚合物连接的毒蜥外泌肽或毒蜥外泌激素的新型修饰的毒蜥外泌肽和毒蜥外泌肽激动剂，以及相关的制剂和剂量以及施用方法。 这些修饰的毒蜥外泌肽和毒蜥外泌肽激动剂，组合物和方法可用于治疗通过降低血浆葡萄糖或延迟和/或减缓胃排空或抑制食物摄取而受益的糖尿病和病症。
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42.发明授权Exendins and exendin agonist analogs to regulate gastrointestinal motility 有权毒蜥外泌肽和毒蜥外泌激素类似物以调节胃肠蠕动公开(公告)号：US08026210B2
公开(公告)日：2011-09-27
申请号：US12353861
申请日：2009-01-14
IPC分类号： A61K38/22
CPC分类号： C07K14/605 , A61K38/00 , A61K38/22 , A61K38/26 , C07K14/57563 , A61K2300/00
摘要： Methods for reducing gastric motility and delaying gastric emptying for therapeutic and diagnostic purposes are disclosed which comprise administration of an effective amount of an exendin or an exendin agonist. Methods for treating conditions associated with elevated, inappropriate, or undesired post-prandial blood glucose levels are disclosed which comprise administration of an effective amount of an exendin or an exendin agonist alone or in conjunction with other anti-gastric emptying agents.
摘要翻译： 公开了减少胃动力和延迟胃排空用于治疗和诊断目的的方法，其包括施用有效量的毒蜥外泌肽或毒蜥外泌肽激动剂。 公开了治疗与升高的，不适当的或不期望的餐后血糖水平相关的病症的方法，其包括单独施用有效量的毒蜥外泌肽或毒蜥外泌肽激素，或与其他抗胃排空剂联合施用。
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公开(公告)号：US07906146B2
公开(公告)日：2011-03-15
申请号：US12389509
申请日：2009-02-20
CPC分类号： C07K14/605 , A61K38/00 , A61K38/16 , A61K38/26 , A61K47/48215 , A61K47/60 , C07K14/57563
摘要： Novel formulations containing exendins, exendin agonists and/or exendin analogs are provided.
摘要翻译： 提供了含有毒蜥外泌肽，毒蜥外泌肽激动剂和/或毒蜥外泌肽类似物的新型制剂。
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公开(公告)号：US07691963B2
公开(公告)日：2010-04-06
申请号：US12101818
申请日：2008-04-11
CPC分类号： C07K14/605 , A61K47/60
摘要： Modified exendins and exendin agonists having an exendin or exendin agonist linked to one or more molecular weight increasing compounds, for example, polyamino acids, polyethylene glycol polymers, and related formulations and dosages and methods of administration thereof are provided. These modified exendins and exendin agonists, compositions comprising the modified exendin or the agonist thereof are useful in treating diabetes and conditions that would be benefited by lowering plasma glucose or delaying and/or slowing gastric emptying or inhibiting food intake.
摘要翻译： 提供了具有连接至一种或多种分子量增加化合物的毒蜥外泌肽或毒蜥外泌激素的修饰的毒蜥外泌肽和毒蜥外泌肽激动剂，例如聚氨基酸，聚乙二醇聚合物，以及相关制剂及其给药方式及其施用方法。 这些修饰的毒蜥外泌肽和毒蜥外泌肽激动剂，包含修饰的毒蜥外泌肽或其激动剂的组合物可用于治疗糖尿病和通过降低血浆葡萄糖或延迟和/或减缓胃排空或抑制食物摄取而受益的病症。
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公开(公告)号：US20080214467A1
公开(公告)日：2008-09-04
申请号：US12101689
申请日：2008-04-11
CPC分类号： C07K14/605 , A61K47/60
摘要： Novel modified exendins and exendin agonists having an exendin or exendin agonist linked to one or more molecular weight increasing compounds, for example, albumin, polyethylene glycol polymers, and related formulations and dosages and methods of administration thereof are provided. These modified exendins and exendin agonists, compositions and methods are useful in treating diabetes and conditions that would be benefited by lowering plasma glucose or delaying and/or slowing gastric emptying or inhibiting food intake.
摘要翻译： 提供了具有与一种或多种分子量增加化合物连接的毒蜥外泌肽或毒蜥外泌激素的新型修饰的毒蜥外泌肽和毒蜥外苷激动剂，例如白蛋白，聚乙二醇聚合物，以及相关制剂及其给药方式及其施用方法。 这些修饰的毒蜥外泌肽和毒蜥外泌肽激动剂，组合物和方法可用于治疗通过降低血浆葡萄糖或延迟和/或减缓胃排空或抑制食物摄取而受益的糖尿病和病症。
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公开(公告)号：US07419952B2
公开(公告)日：2008-09-02
申请号：US11368225
申请日：2006-03-03
CPC分类号： A61K9/0019 , A61K38/00 , A61K38/22 , A61K38/2207 , A61K38/2264 , A61K38/23 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/26 , A61K47/44 , C07K14/57563 , Y10S514/866 , A61K2300/00
摘要： Methods for treating conditions or disorders which can be alleviated by reducing food intake are disclosed which comprise administration of an effective amount of an exendin or an exendin agonist, alone or in conjunction with other compounds or compositions that affect satiety. The methods are useful for treating conditions or disorders, including obesity, Type II diabetes, eating disorders, and insulin-resistance syndrome. The methods are also useful for lowering the plasma glucose level, lowering the plasma lipid level, reducing the cardiac risk, reducing the appetite, and reducing the weight of subjects. Pharmaceutical compositions for use in the methods of the invention are also disclosed.
摘要翻译： 公开了通过减少食物摄入可以缓解的病症或病症的方法，其包括单独施用有效量的毒蜥外泌肽或毒蜥外泌肽激素，或与影响饱腹感的其它化合物或组合物联合施用。 该方法可用于治疗条件或障碍，包括肥胖，II型糖尿病，进食障碍和胰岛素抵抗综合征。 该方法对于降低血浆葡萄糖水平，降低血浆脂质水平，降低心脏风险，降低食欲和降低受试者的体重也是有用的。 还公开了用于本发明方法的药物组合物。
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公开(公告)号：US07105490B2
公开(公告)日：2006-09-12
申请号：US10629649
申请日：2003-07-30
CPC分类号： A61K45/06 , A61K38/2278 , A61K38/24 , A61K38/26 , A61K2300/00
摘要： The present invention relates to methods of treating polycystic ovary syndrome (PCOS) comprising administering glucagon-like peptide-1 (GLP-1), exendin, and analogs and agonists thereof, to subjects suffering therefrom.
摘要翻译： 本发明涉及治疗多囊卵巢综合征（PCOS）的方法，其包括向患有受试者的患者施用胰高血糖素样肽-1（GLP-1），毒蜥外泌肽及其类似物和激动剂。
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公开(公告)号：US06872700B1
公开(公告)日：2005-03-29
申请号：US09889331
申请日：2000-01-14
IPC分类号： A61K47/48 , A61K20060101 , A61K38/00 , A61K38/02 , A61K38/22 , A61K38/26 , A61K45/00 , A61P5/00 , A61P5/48 , A61P17/00 , A61P35/00 , C07K14/435 , C07K14/575
CPC分类号： C07K14/57563 , A61K38/00 , A61K47/60
摘要： Methods for use of an exendin, an exendin agonist, or a modified exendin or exendin agonist having an exendin or exendin agonist linked to one or more polyethylene glycol polymers, for example, for lowering glucagon levels and/or suppressing glucagon secretion in a subject are provide. These methods are useful in treating hyperglucagonemia and other conditions that would be benefited by lowering plasma glucagon or suppressing glucagon secretion.
摘要翻译： 使用与一种或多种聚乙二醇聚合物连接的毒蜥外泌肽或毒蜥外泌激素，例如降低胰高血糖素水平和/或抑制受试者中胰高血糖素分泌的毒蜥外泌肽，毒蜥外泌肽激动剂或经修饰的毒蜥外泌肽或毒蜥外泌肽激素的方法是： 提供。 这些方法可用于治疗通过降低血浆胰高血糖素或抑制胰高血糖素分泌而受益的高胰高血糖素血症和其它病症。
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公开(公告)号：US6114304A
公开(公告)日：2000-09-05
申请号：US302069
申请日：1994-09-07
IPC分类号： A61K45/00 , A61K35/39 , A61K38/22 , A61K38/23 , A61K49/00 , A61P1/00 , A61P1/14 , A61P3/10 , A61P25/02 , A61P43/00 , C07K14/585 , A61K37/02 , C07K7/10 , C07K7/36
CPC分类号： A61K38/23 , A61K38/22 , Y10S514/866
摘要： Methods for treating conditions associated with elevated, inappropriate or undesired post-prandial blood glucose levels are disclosed which comprise administration of an effective amount of an amylin agonist alone or in conjunction with other anti-gastric emptying agents. Methods for reducing gastric motility and delaying gastric emptying for therapeutic and diagnostic purposes are also described.
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50.发明授权Methods of treating diabetes and/or obesity using an enteroendocrine peptide secretion enhancing agent 有权使用肠内分泌肽分泌增强剂治疗糖尿病和/或肥胖症的方法公开(公告)号：US08318663B2
公开(公告)日：2012-11-27
申请号：US12624345
申请日：2009-11-23
CPC分类号： A61K31/4985 , A61K9/0031 , A61K9/02 , A61K9/06 , A61K9/08 , A61K9/122 , A61K9/2054 , A61K9/284 , A61K9/2866 , A61K31/575 , A61K35/413 , A61K45/06 , A61K2300/00
摘要： Provided herein are methods and compositions for treating metabolic diseases and conditions associated with metabolic diseases.
摘要翻译： 本文提供了用于治疗与代谢疾病相关的代谢疾病和病症的方法和组合物。
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