公开(公告)号：US20060292573A1

公开(公告)日：2006-12-28

申请号：US11129653

申请日：2005-05-16

申请人： Gregory Plowman ,  Peter Flanagan

发明人： Gregory Plowman ,  Peter Flanagan

IPC分类号： C12Q1/68 ,  G01N33/567 ,  C07H21/04 ,  C12P21/06 ,  C07K14/705 ,  C07K16/28

CPC分类号： C12N9/1205 ,  C07K2319/00 ,  C12Q1/485 ,  G01N33/574

摘要： The present invention relates in part to hWART nucleic acid molecules. The invention also relates in part to nucleic acid molecules encoding portions of hWART full-length proteins, nucleic acid vectors containing hWART nucleic acid molecules, recombinant cells containing such nucleic acid vectors, polypeptides purified from such recombinant cells, antibodies to such polypeptides, and methods of identifying compounds that modulate the function of an hWART polypeptide. Also disclosed are methods for diagnosing abnormal cell proliferative conditions in an organism using hWART-related molecules or compounds.

摘要翻译： 本发明部分涉及hWART核酸分子。 本发明还部分涉及编码hWART全长蛋白质的部分的核酸分子，含有hWART核酸分子的核酸载体，含有此类核酸载体的重组细胞，从这种重组细胞纯化的多肽，对这些多肽的抗体，以及方法 鉴定调节hWART多肽功能的化合物。 还公开了使用hWART相关分子或化合物诊断生物体中异常细胞增殖状态的方法。

公开(公告)号：US20060204994A1

公开(公告)日：2006-09-14

申请号：US11367775

申请日：2006-03-06

申请人： Gregory Plowman ,  David Whyte ,  Gerard Manning ,  Sucha Sudarsanam ,  Ricardo Martinez ,  Sean Caenepeel

发明人： Gregory Plowman ,  David Whyte ,  Gerard Manning ,  Sucha Sudarsanam ,  Ricardo Martinez ,  Sean Caenepeel

IPC分类号： C12Q1/68 ,  C07H21/04 ,  C12P21/06 ,  C12N9/12

CPC分类号： C12N9/1205 ,  A61K38/00

摘要： The present invention relates to kinase polypeptides, nucleotide sequences encoding the kinase polypeptides, as well as various products and methods useful for the diagnosis and treatment of various kinase-related diseases and conditions. Through the use of a bioinformatics strategy, mammalian members of the PTK's and STK's have been identified and their protein structure predicted.

公开(公告)号：US20060019305A1

公开(公告)日：2006-01-26

申请号：US11197489

申请日：2005-08-05

申请人： Gregory Plowman ,  Bahija Jallal

发明人： Gregory Plowman ,  Bahija Jallal

IPC分类号： C12Q1/68 ,  C07H21/04 ,  C12P21/06 ,  C07K14/82

CPC分类号： C12N9/1205 ,  C07K14/705 ,  C07K16/40 ,  C07K2319/00 ,  C12N9/16 ,  Y10S530/828 ,  Y10S530/829

摘要： The present invention relates to PTP05 polypeptides and PTP10 polypeptides, nucleic acids encoding such polypeptides, cells, tissues and animals containing such nucleic acids, antibodies to such polypeptides, assays utilizing such polypeptides, and methods relating to all of the foregoing. Methods for treatment, diagnosis, and screening are provided for PTP05 and/or PTP10 related diseases or conditions characterized by an abnormal interaction between a PTP05 polypeptide and a PTP05 binding partner and/or a PTP10 polypeptide and a PTP10 binding partner.

公开(公告)号：US06207401B1

公开(公告)日：2001-03-27

申请号：US09283011

申请日：1999-03-31

申请人： Gregory Plowman ,  Kevin Mossie

发明人： Gregory Plowman ,  Kevin Mossie

IPC分类号： C12Q154

CPC分类号： C12N9/1205 ,  A01K2217/05 ,  A61K38/00 ,  C12Q1/485 ,  G01N2333/9121 ,  G01N2500/02 ,  G01N2500/04 ,  G01N2500/10

摘要： The present invention relates to AUR1 and/or AUR2 polypeptides, nucleic acids encoding such polypeptides, cells, tissues and animals containing such nucleic acids, antibodies to such polypeptides, assays utilizing such polypeptides, and methods relating to all of the foregoing. Methods for treatment, diagnosis, and screening are provided for AUR1 and/or AUR2 related diseases or conditions characterized by an abnormal interaction between a AUR1 and/or AUR2 polypeptide and a AUR1 and/or AUR2 binding partner.

摘要翻译： 本发明涉及AUR1和/或AUR2多肽，编码此类多肽的核酸，含有此类核酸的细胞，组织和动物，此类多肽的抗体，利用此类多肽的测定法以及与上述所有相关的方法。 AUR1和/或AUR2相关疾病或特征为AUR1和/或AUR2多肽与AUR1和/或AUR2结合配偶体之间异常相互作用的病症的治疗，诊断和筛选方法。