公开(公告)号：US08435985B2

公开(公告)日：2013-05-07

申请号：US13307342

申请日：2011-11-30

申请人： Keith Menear ,  Graeme Cameron Murray Smith ,  Karine Malagu ,  Heather Mary Ellen Duggan ,  Niall Morrison Barr Martin ,  Frederic Georges Marie Leroux

发明人： Keith Menear ,  Graeme Cameron Murray Smith ,  Karine Malagu ,  Heather Mary Ellen Duggan ,  Niall Morrison Barr Martin ,  Frederic Georges Marie Leroux

IPC分类号： A61K31/535 ,  C07D413/14

CPC分类号： A61K31/5377 ,  A61K31/565 ,  A61K45/06 ,  C07D413/14 ,  C07D471/04 ,  C07D475/08 ,  C07D475/10

摘要： There is provided a compound of formula I: or a pharmaceutically acceptable salt thereof. There are also provided processes for the manufacture of a compound of Formula 1, and the use of a compound of Formula 1 as a medicament and in the treatment of cancer.

公开(公告)号：US08101602B2

公开(公告)日：2012-01-24

申请号：US13014275

申请日：2011-01-26

申请人： Keith Menear ,  Graeme Cameron Murray Smith ,  Karine Malagu ,  Heather Mary Ellen Duggan ,  Niall Morrison Barr Martin ,  Frederic Georges Marie Leroux

发明人： Keith Menear ,  Graeme Cameron Murray Smith ,  Karine Malagu ,  Heather Mary Ellen Duggan ,  Niall Morrison Barr Martin ,  Frederic Georges Marie Leroux

IPC分类号： A61K31/5377 ,  C07D413/14

CPC分类号： A61K31/5377 ,  A61K31/565 ,  A61K45/06 ,  C07D413/14 ,  C07D471/04 ,  C07D475/08 ,  C07D475/10

摘要： There is provided a compound of formula I: or a pharmaceutically acceptable salt thereof. There are also provided processes for the manufacture of a compound of Formula 1, and the use of a compound of Formula 1 as a medicament and in the treatment of cancer.

摘要翻译： 提供式I化合物或其药学上可接受的盐。 还提供了制备式1化合物的方法和式1化合物作为药物和用于治疗癌症的用途。

公开(公告)号：US06664269B2

公开(公告)日：2003-12-16

申请号：US10135247

申请日：2002-04-30

申请人： Niall Morrison Barr Martin ,  Graeme Cameron Murray Smith ,  Charles Richard White ,  Roger Frank Newton ,  Diana Gillian Douglas ,  Penny Jane Eversley ,  Alan John Whittle

发明人： Niall Morrison Barr Martin ,  Graeme Cameron Murray Smith ,  Charles Richard White ,  Roger Frank Newton ,  Diana Gillian Douglas ,  Penny Jane Eversley ,  Alan John Whittle

IPC分类号： A61K3147

CPC分类号： C07D401/12 ,  A61K31/47 ,  A61K31/4725 ,  C07D217/24 ,  C07D405/06 ,  C07D405/12 ,  C07D409/12 ,  C07D417/12 ,  C07D417/14

摘要： Derivatives of isoquinolinone and dihydrolisoquinolinone, and related compounds, and their use as pharmaceuticals in the treatment of a disease by inhibition of the enzyme poly(ADP-ribose)polymerase (“PARP”) are disclosed.

摘要翻译： 公开了异喹啉酮和二氢异喹啉酮的衍生物及其相关化合物及其作为药物用于通过抑制聚（ADP-核糖）聚合酶（“PARP”）的治疗疾病的用途。

公开(公告)号：US20110130386A1

公开(公告)日：2011-06-02

申请号：US12989510

申请日：2009-04-24

申请人： Mark Frigerio ,  Heather Mary Ellen Duggan ,  Marc Geoffrey Hummersone ,  Keith Allan Menear ,  Niall Morrison Barr Martin ,  Celine Cano ,  Roger John Griffin ,  Bernard Thomas Golding ,  Ian Robert Hardcastle

发明人： Mark Frigerio ,  Heather Mary Ellen Duggan ,  Marc Geoffrey Hummersone ,  Keith Allan Menear ,  Niall Morrison Barr Martin ,  Celine Cano ,  Roger John Griffin ,  Bernard Thomas Golding ,  Ian Robert Hardcastle

IPC分类号： A61K31/551 ,  C07D413/14 ,  C07D243/06 ,  C12N5/071 ,  A61K31/5355 ,  A61K31/55 ,  A61P35/00

CPC分类号： C07D413/14 ,  C07D417/14

摘要： A compound of formula (I) wherein: R1 and R2 are independently selected from hydrogen, an optionally substituted C1-7 alkyl group, C3-20 heterocyclyl group, or C5-20 aryl group, or may together form, along with the nitrogen atom to which they are attached, an optionally substituted heterocyclic ring having from 4 to 8 ring atoms; and RN1 and RN2 are selected from hydrogen, an optionally substituted C1-7 alkyl group, C3-20 heterocyclyl group, or C5-20 aryl group, or may together form, along with the nitrogen atom to which they are attached, an optionally substituted heterocyclic ring having from 4 to 8 ring atoms.

摘要翻译： 式（I）的化合物，其中：R 1和R 2独立地选自氢，任选取代的C 1-7烷基，C 3-20杂环基或C 5-20芳基，或者可以与氮原子一起形成 与它们相连的任选取代的具有4至8个环原子的杂环; 并且RN1和RN2选自氢，任选取代的C 1-7烷基，C 3-20杂环基或C 5-20芳基，或者可以与它们所连接的氮原子一起形成任选取代的 具有4至8个环原子的杂环。