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公开(公告)号:US06593346B2
公开(公告)日:2003-07-15
申请号:US10075163
申请日:2002-02-14
申请人: Paul E. Finke , Kerry A. Hilfiker , Malcolm MacCoss , Kevin T. Chapman , Jennifer L. Loebach , Sander G. Mills , Ravi N. Guthikonda , Shrenik K. Shah , Dooseop Kim , Dong-Ming Shen , Bryan Oates
发明人: Paul E. Finke , Kerry A. Hilfiker , Malcolm MacCoss , Kevin T. Chapman , Jennifer L. Loebach , Sander G. Mills , Ravi N. Guthikonda , Shrenik K. Shah , Dooseop Kim , Dong-Ming Shen , Bryan Oates
IPC分类号: A61K31445
CPC分类号: C07D401/04 , C07D211/14 , C07D211/18 , C07D211/20 , C07D211/24 , C07D211/34 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/14 , C07D413/04 , C07D413/06 , C07D417/04 , C07D471/04 , Y02P20/582
摘要: The present invention is directed to compounds of the formula I: (wherein R1, R3, R4, R5, R6, R7, R8, X, n, x and y are defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptors CCR-5 and/or CCR-3.