摘要:
The invention relates to linear γ-carboxyglutamate rich conotoxins, derivatives or pharmaceutically acceptable salts thereof, and uses thereof, including the treatment of neurologic and psychiatric disorders, such as anticonvillsant agents, as neuroprotective agents or for the management of pain. The invention further relates to nucleic acid sequences encoding the conopeptides and encoding propeptides, as well as the propeptides.
摘要:
A training belt for wearing around a waist of a user is disclosed. The belt comprises a flexible strap that terminates at a first end in a first adjustment strap that has an attachment means fixed therewith. A second end of the flexible strap includes a second adjustment strap terminating with a loop. An outside surface of the training belt includes at least one pocket that extends substantially along the length of the flexible strap. Each pocket includes a closure means extending substantially therealong for retaining one or more weighted tubes. An inside surface of the flexible strap may include a cushioning pad, made of a memory-foam type material, for example, extending substantially around the length and height of the flexible strap.
摘要:
Systems and methods for diagnosing faults in well servicing operations and determining appropriate remedial action to remedy such faults. This abstract is provided to comply with the rules requiring an abstract which will allow a searcher or other reader to quickly ascertain the subject matter of the technical disclosure. It is submitted with the understanding that it will not be used to interpret or limit the scope or meaning of the claims, 37 CFR 1.72(b).
摘要:
This invention relates to polyurethane elastomers and to a process for their production. These elastomers comprise the reaction product of a polyisocyanate component comprising an allophanate modified (cyclo)aliphatic polyisocyanate which has an NCO group content of about 15 to about 35% or a prepolymer thereof, with an isocyanate-reactive component comprising one or more polyether polyols which is free of amine groups, and a low molecular weight organic compound containing two hydroxyl groups and which is free of amine groups, in the presence of one or more catalysts.
摘要:
This invention relates to polyurethane elastomers and to a process for their production. These elastomers comprise the reaction product of a (cyclo)aliphatic isocyanate component having an NCO group content of about 20 to about 45%, with an isocyanate-reactive component comprising one or more polyether polyols which is free of amine groups, and a low molecular weight organic compound containing two hydroxyl groups and which is free of amine groups, in the presence of one or more catalysts.
摘要:
The present invention is directed to a polyisocyanate mixture i) having a monomeric diisocyanate content of less than 3% by weight, ii) having a urethane group content of more than 50 equivalent %, based on the total equivalents of urethane and allophanate groups, and iii) containing siloxane groups (calculated as SiO, MW 44) in an amount of 0.002 to 50% by weight, wherein the preceding percentages are based on the solids content of the polyisocyanate mixture and wherein the siloxane groups are incorporated by reacting a) an isocyanate group from a polyisocyanate adduct containing isocyanurate groups and prepared from a monomeric diisocyanate having at least one cycloaliphatic group with b) a compound containing one or more hydroxyl groups directly attached to a carbon atom and one or more siloxane groups to form urethane groups. The present invention also relates to the use of this polyisocyanate mixture, optionally in blocked form, as an isocyanate component in one- or two-component coating compositions.
摘要:
The present invention is directed to a polyisocyanate mixture i) having an NCO content of 5 to 35% by weight and a monomeric diisocyanate content of less than 3% by weight, and prepared from a polyisocyanate adduct, ii) containing allophanate groups in an amount such that there are more equivalents of allophanate groups than urethane groups and iii) containing fluorine (calculated as F, AW 19) in an amount of 0.001 to 50% by weight, wherein the preceding percentages are based on the solids content of the polyisocyanate mixture and wherein fluorine is incorporated by reacting an isocyanate group with a compound containing two or more carbon atoms, one or more hydroxyl groups and one or more fluorine atoms. The present invention is also directed to a process for the production of this polyisocyanate mixture and to its use, optionally in blocked form, as an isocyanate component in one- or two-component coating compositions.
摘要:
The present invention is directed to P-superfamily conopeptides, to DNA encoding precursors of the P-superfamily conopeptides and to the precursor peptides.
摘要:
Protein disulfide isomerase is a major component of Conus venom ducts. The invention relates to a protein disulfide isomerase (PDI) from Conus snails, a nucleic acid sequence encoding the Conus protein disulfide isomerase, and to methods for folding disulfide-rich peptides using a protein disulfide isomerase. Oxidative folding of conotoxin precursors, catalyzed by a PDI, was more efficient and decreased the number and concentration of transiently accumulated folding species. The PDI-assisted oxidative folding of conotoxins was also influenced by the propeptide relative to the mature peptide.
摘要:
The present invention is directed to conopeptides termed conkunitzins and their use for blocking the flow of potassium ions through voltage-gated potassium channels. In view of the Kunitz domain in the conkunitzins, they are also useful for inhibiting platelet aggregation and as protease inhibitors.