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公开(公告)号：US20060199245A1
公开(公告)日：2006-09-07
申请号：US11216937
申请日：2005-08-31
申请人： Grzegorz Bulaj , Baldomero Olivera , Olga Buczek , James Garrett , Ian Goodsell
发明人： Grzegorz Bulaj , Baldomero Olivera , Olga Buczek , James Garrett , Ian Goodsell
CPC分类号： C07H21/04 , C12N9/90 , C12Y503/04001
摘要： Protein disulfide isomerase is a major component of Conus venom ducts. The invention relates to a protein disulfide isomerase (PDI) from Conus snails, a nucleic acid sequence encoding the Conus protein disulfide isomerase, and to methods for folding disulfide-rich peptides using a protein disulfide isomerase. Oxidative folding of conotoxin precursors, catalyzed by a PDI, was more efficient and decreased the number and concentration of transiently accumulated folding species. The PDI-assisted oxidative folding of conotoxins was also influenced by the propeptide relative to the mature peptide.
摘要翻译： 蛋白二硫键异构酶是Conus毒液管的主要成分。 本发明涉及来自Conus蜗牛的蛋白质二硫键异构酶（PDI），编码康科斯蛋白二硫键异构酶的核酸序列，以及使用蛋白质二硫键异构酶折叠富含二硫键的肽的方法。 通过PDI催化的芋螺毒素前体的氧化折叠更有效，并且减少了瞬时积累的折叠物质的数量和浓度。 脯氨酸的PDI辅助氧化折叠也受到前肽相对于成熟肽的影响。
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公开(公告)号：US20060014673A1
公开(公告)日：2006-01-19
申请号：US11174996
申请日：2005-07-06
申请人： Richard Layer , Karen Pemberton , Robert Jones , James Garrett , Baldomero Olivera , J. McIntosh , David Hillyard , Michelle Grilley , Maren Watkins , Ameurfina Santos , Glenn Zafaralla , A. Craig
发明人： Richard Layer , Karen Pemberton , Robert Jones , James Garrett , Baldomero Olivera , J. McIntosh , David Hillyard , Michelle Grilley , Maren Watkins , Ameurfina Santos , Glenn Zafaralla , A. Craig
IPC分类号： A61K38/16 , C07K14/435
CPC分类号： A61K38/17 , C07K14/43504
摘要： The present invention is directed to kappaA (κA) conopeptides and the use of these peptides for blocking the flow of potassium ions through voltage-gated potassium channels. The κA conopeptides include unglycosylated and O-glycosylated peptides.
摘要翻译： 本发明涉及kappaA（kappaA）肽以及这些肽用于阻断通过电压门控钾通道的钾离子流动的用途。 κA肽包括非糖基化和O-糖基化肽。
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公开(公告)号：US20060172948A1
公开(公告)日：2006-08-03
申请号：US11385997
申请日：2006-03-22
申请人： Baldomero Olivera , J. McIntosh , James Garrett , Craig Walker , Maren Watkins , Robert Jones
发明人： Baldomero Olivera , J. McIntosh , James Garrett , Craig Walker , Maren Watkins , Robert Jones
IPC分类号： A61K38/10 , C07K7/08 , C07K14/435
CPC分类号： C07K7/08 , A61K38/00 , C07K7/02 , C07K14/43504
摘要： The invention relates to γ-carboxyglutamate containing conopeptides, derivatives or pharmaceutically acceptable salts thereof, and uses thereof, including the treatment of neurologic and psychiatric disorders, such as anticonvulsant agents, as neuroprotective agents or for the management of pain. The invention further relates to nucleic acid sequences encoding the conopeptides and encoding propeptides, as well as the propeptides.
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公开(公告)号：US20050159586A1
公开(公告)日：2005-07-21
申请号：US11018369
申请日：2004-12-22
申请人： Baldomero Olivera , J. McIntosh , James Garrett , Craig Walker , Maren Watkins , Robert Jones
发明人： Baldomero Olivera , J. McIntosh , James Garrett , Craig Walker , Maren Watkins , Robert Jones
IPC分类号： A61K38/00 , A61P25/18 , A61P25/24 , A61P25/28 , C07K14/435
CPC分类号： C07K14/43504 , A61K38/00
摘要： The invention relates to linear γ-carboxyglutamate rich conotoxins, derivatives or pharmaceutically acceptable salts thereof, and uses thereof, including the treatment of neurologic and psychiatric disorders, such as anticonvillsant agents, as neuroprotective agents or for the management of pain. The invention further relates to nucleic acid sequences encoding the conopeptides and encoding propeptides, as well as the propeptides.
摘要翻译： 本发明涉及富含线性的γ-羧基谷氨酸富含芋螺毒素，其衍生物或其药学上可接受的盐及其用途，包括治疗神经系统疾病和精神病学疾病如抗惊厥药，作为神经保护剂或用于治疗疼痛。 本发明还涉及编码肽和编码前肽以及前肽的核酸序列。
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公开(公告)号：US20050143560A1
公开(公告)日：2005-06-30
申请号：US10893300
申请日：2004-07-19
申请人： J. McIntosh , Baldomero Olivera , Lourdes Cruz , Gloria Corpuz , Robert Jones , James Garrett
发明人： J. McIntosh , Baldomero Olivera , Lourdes Cruz , Gloria Corpuz , Robert Jones , James Garrett
IPC分类号： A61K38/00 , C07K14/435 , C07K7/08
CPC分类号： C07K14/43504 , A61K38/00 , Y10S530/857
摘要： The invention relates to relatively short conotoxin peptides, about 10-20 residues in length as described herein, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which preferably include two disulfide bonds. These conotoxin peptides have analgesic activity and are thus useful for treating or preventing pain.
摘要翻译： 本发明涉及相对较短的荚毒素肽，如本文所述，其长度约为10-20个残基，其可以在锥形蜗牛的毒液中以微量天然存在或类似于天然可得的肽，并且其优选包括两个二硫键。 这些芋螺毒素肽具有止痛活性，因此可用于治疗或预防疼痛。
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公开(公告)号：US20060205656A1
公开(公告)日：2006-09-14
申请号：US11389172
申请日：2006-03-27
申请人： David Hooper , James Garrett , Gloria Corpuz , Lourdes Cruz , Baldomero Olivera , J. McIntosh , Robert Jones
发明人： David Hooper , James Garrett , Gloria Corpuz , Lourdes Cruz , Baldomero Olivera , J. McIntosh , Robert Jones
IPC分类号： A61K38/16 , C07K14/435
CPC分类号： A61K49/0004 , A61K38/00 , C07K14/43504
摘要： The present invention is directed to P-superfamily conopeptides, to DNA encoding precursors of the P-superfamily conopeptides and to the precursor peptides.
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公开(公告)号：US20060178303A1
公开(公告)日：2006-08-10
申请号：US11222216
申请日：2005-09-09
IPC分类号： A61K38/16 , C07K14/435
CPC分类号： C07K14/43504 , A61K38/00
摘要： The present invention is directed to conopeptides termed conkunitzins and their use for blocking the flow of potassium ions through voltage-gated potassium channels. In view of the Kunitz domain in the conkunitzins, they are also useful for inhibiting platelet aggregation and as protease inhibitors.
摘要翻译： 本发明涉及称为康尼他嗪的肽，以及它们用于阻断钾离子通过电压门控钾通道流动的用途。 鉴于康un嗪中的Kunitz结构域，它们也可用于抑制血小板聚集和蛋白酶抑制剂。
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公开(公告)号：US20060241046A1
公开(公告)日：2006-10-26
申请号：US11476638
申请日：2006-06-29
申请人： Baldomero Olivera , J. McIntosh , James Garrett , Craig Walker , Maren Watkins , Robert Jones
发明人： Baldomero Olivera , J. McIntosh , James Garrett , Craig Walker , Maren Watkins , Robert Jones
IPC分类号： A61K38/16 , A61K38/10 , C07K14/435
CPC分类号： C07K14/43504 , A61K38/00
摘要： The invention relates to linear y-carboxyglutamate rich conotoxins, derivatives or pharmaceutically acceptable salts thereof, and uses thereof, including the treatment of neurologic and psychiatric disorders, such as anticonvulsant agents, as neuroprotective agents or for the management of pain. The invention further relates to nucleic acid sequences encoding the conopeptides and encoding propeptides, as well as the propeptides.
摘要翻译： 本发明涉及线性γ-羧基谷氨酸富含芋螺毒素，其衍生物或药学上可接受的盐及其用途，包括治疗神经和精神疾病，如抗惊厥剂，神经保护剂或用于治疗疼痛。 本发明还涉及编码肽和编码前肽以及前肽的核酸序列。
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公开(公告)号：US20050271589A1
公开(公告)日：2005-12-08
申请号：US11198847
申请日：2005-08-08
申请人： Robert Jones , Baldomero Olivera , Maren Watkins , James Garrett
发明人： Robert Jones , Baldomero Olivera , Maren Watkins , James Garrett
IPC分类号： A61K51/00 , A61K51/08 , C07H21/04 , C07K14/435 , C12N15/12
CPC分类号： C07K14/43504
摘要： The present invention is directed to β-superfamily conotoxin peptides, derivatives or pharmaceutically acceptable salts thereof. The present invention is further directed to the use of this peptide, derivatives thereof and pharmaceutically acceptable salts thereof for the treatment of disorders associated with voltage-gated ion channels, ligand gated channels and other receptors. The invention is further directed to nucleic acid sequences encoding the β-superfamily conotoxin peptides and encoding β-superfamily conotoxin propeptides, as well as the β-superfamily conotoxin propeptides.
摘要翻译： 本发明涉及β-超家族荚果毒素肽，其衍生物或药学上可接受的盐。 本发明进一步涉及该肽，其衍生物和其药学上可接受的盐在治疗与电压门控离子通道，配体门控通道和其它受体相关的病症中的用途。 本发明还涉及编码β-超家族荚果毒素肽和编码β-超家族荚果毒素前肽以及β-超家族荚果毒素前肽的核酸序列。
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公开(公告)号：US20050214213A1
公开(公告)日：2005-09-29
申请号：US11097315
申请日：2005-04-04
申请人： Baldomero Olivera , J. McIntosh , Maren Watkins , James Garrett , Lourdes Cruz , Michelle Grilley , Robert Schoenfeld , Craig Walker , Reshma Shetty , Robert Jones
发明人： Baldomero Olivera , J. McIntosh , Maren Watkins , James Garrett , Lourdes Cruz , Michelle Grilley , Robert Schoenfeld , Craig Walker , Reshma Shetty , Robert Jones
IPC分类号： A61K38/00 , C07K14/435 , C12N5/02 , A61K51/00 , A61K38/16
CPC分类号： C07K14/43504 , A61K38/00
摘要： The present invention is directed to conotoxin peptides, derivatives or pharmaceutically acceptable salts thereof. The present invention is further directed to the use of this peptide, derivatives thereof and pharmaceutically acceptable salts thereof for the treatment of disorders associated with voltage-gated ion channels, voltage-gated ligand channels and/or receptors. The invention is further directed to nucleic acid sequences encoding the conotoxin peptides and encoding propeptides, as well as the propeptides.
摘要翻译： 本发明涉及芋螺毒素肽，其衍生物或药学上可接受的盐。 本发明进一步涉及该肽，其衍生物和其药学上可接受的盐在治疗与电压门控离子通道，电压门控配体通道和/或受体相关的病症中的用途。 本发明还涉及编码芋螺毒素肽和编码前肽以及前肽的核酸序列。
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