公开(公告)号：US5256296A

公开(公告)日：1993-10-26

申请号：US943923

申请日：1992-09-11

申请人： Richard W. Baker ,  Johannes G. Wijmans

发明人： Richard W. Baker ,  Johannes G. Wijmans

IPC分类号： B01D53/22

CPC分类号： B01D53/226

摘要： A membrane separation process and system for removing a component from a fluid stream. An auxiliary membrane module or set of modules is installed across the pump that drives the main membrane unit, so that the permeate streams from the main and auxiliary membrane units are mixed and pass together through a common driving pump. The concentration of the mixed permeate stream is allowed to build up by circulating the stream through the auxiliary unit. When the concentration has reached a desired level, the mixed stream can be tapped and the product stream drawn off.

摘要翻译： 用于从流体流中去除组分的膜分离过程和系统。 辅助膜组件或一组模块安装在驱动主膜单元的泵的两侧，使得来自主膜单元和辅助膜单元的渗透物流混合并通过公共驱动泵通过。 混合的渗透物流的浓度允许通过使流通过辅助单元循环而形成。 当浓度达到所需水平时，可以将混合物流轻敲并将产物流抽出。

公开(公告)号：US5129921A

公开(公告)日：1992-07-14

申请号：US707754

申请日：1991-05-30

申请人： Richard W. Baker ,  Johannes G. Wijmans

发明人： Richard W. Baker ,  Johannes G. Wijmans

IPC分类号： B01D53/22

CPC分类号： B01D53/22

摘要： A system and process useful for a gas separation operation. The system includes three components: a membrane unit, a pump, blower, ejector or the like to provide gas flow to the membrane unit and a gas holding vessel. The system and process can be used to treat any type of gas flow, but have particular advantages for handling streams where the gas flow varies substantially over time.

摘要翻译： 用于气体分离操作的系统和过程。 该系统包括三个部件：膜单元，泵，鼓风机，喷射器等，以提供气体流到膜单元和气体保持容器。 该系统和过程可用于处理任何类型的气流，但是对于处理气体流随着时间而显着变化的流具有特别的优点。

公开(公告)号：US4943435A

公开(公告)日：1990-07-24

申请号：US264397

申请日：1988-10-28

申请人： Richard W. Baker ,  Frank Kochinke ,  Carl Huang

发明人： Richard W. Baker ,  Frank Kochinke ,  Carl Huang

IPC分类号： A61K9/70 ,  A61K31/465 ,  A61M35/00

CPC分类号： A61K9/7053 ,  A61K31/465 ,  A61K9/7069 ,  A61K9/7084 ,  A61M35/00

摘要： A transdermal patch for delivering nicotine for prolonged periods of 12-24 hours. The patch includes a rate-controlling membrane or monolith to keep the nicotine flux within useful and safe limits. The patch is typically replaced once a day, and can be used for smoking cessation therapy or in other situations where systemic nicotine delivery is indicated.

摘要翻译： 一种透皮贴剂，用于长时间的服用尼古丁12-24小时。 贴剂包括速率控制膜或整料，以将尼古丁通量保持在有用和安全的范围内。 补片通常每天更换一次，可用于戒烟治疗或其他情况，其中指示系统性尼古丁递送。

公开(公告)号：US4839174A

公开(公告)日：1989-06-13

申请号：US105549

申请日：1987-10-05

申请人： Richard W. Baker ,  Frank Kochinke ,  Carl Huang

发明人： Richard W. Baker ,  Frank Kochinke ,  Carl Huang

IPC分类号： A61F5/00 ,  A61K9/70 ,  A61K31/465

CPC分类号： A61K9/7069 ,  A61F5/00 ,  A61K31/465 ,  A61K9/7084

摘要： A controlled release transdermal delivery system for nicotine administration. The system comprises an impermeable backing layer, a polyurethane matrix layer containing between about 5 wt % and 50 wt % nicotine, and an adhesive skin-contacting layer. The system is designed to administer nicotine for smoking cessation therapy or other uses over a period of 24 hours or more.

摘要翻译： 用于尼古丁给药的控释透皮递送系统。 该系统包括不渗透背衬层，含有约5重量％至50重量％尼古丁的聚氨酯基质层和粘合剂皮肤接触层。 该系统设计用于在24小时或更长时间内施用戒烟治疗或其他用途的尼古丁。

公开(公告)号：US4553983A

公开(公告)日：1985-11-19

申请号：US636474

申请日：1984-07-31

申请人： Richard W. Baker

发明人： Richard W. Baker

IPC分类号： B01D53/22 ,  B01D71/24

CPC分类号： B01D71/24 ,  B01D53/22

摘要： A process for recovering and concentrating organic vapor from a feed stream of air having an organic vapor content of no more than 20,000 ppm by volume. A thin semipermeable membrane is provided which has a feed side and a permeate side, a selectivity for organic vapor over air of at least 50, as measured by the ratio of organic vapor permeability to nitrogen permeability, and a permeability of organic vapor of at least 3.times.10.sup.-7 cm.sup.3 (STP) cm/cm.sup.2 sec.cm Hg. The feed stream is passed across the feed side of the thin semipermeable membrane while providing a pressure on the permeate side which is lower than the feed side by creating a partial vacuum on the permeate side so that organic vapor passes preferentially through the membrane to form an organic vapor depleted air stream on the feed side and an organic vapor enriched stream on the permeate side. The organic vapor which has passed through the membrane is compressed and condensed to recover the vapor as a liquid.

摘要翻译： 从有机蒸汽含量不超过20,000体积ppm的空气进料流中回收和浓缩有机蒸气的方法。 提供了一种薄的半透膜，其具有进料侧和渗透侧，通过有机蒸气透过率与氮渗透性的比率和至少有机蒸气的渗透性测量，对空气中的有机蒸气的选择性为至少50％ 3×10 -7 cm 3（STP）cm / cm 2 sec·cm Hg。 进料流通过薄薄半透膜的进料侧，同时通过在渗透侧产生部分真空而在渗透侧低于进料侧提供压力，使得有机蒸气优先通过膜以形成 进料侧有机蒸气消耗的空气流和渗透侧的有机蒸汽富集料流。 已经通过膜的有机蒸气被压缩和冷凝以回收蒸气作为液体。

公开(公告)号：US4550370A

公开(公告)日：1985-10-29

申请号：US701055

申请日：1985-02-13

申请人： Richard W. Baker

发明人： Richard W. Baker

IPC分类号： A61N1/372 ,  G06F15/42

CPC分类号： A61N1/37223 ,  A61N1/37252 ,  Y10S128/904

摘要： A programmer for a pacemaker which has telemetric capabilities is disclosed. The programmer, in addition to being able to program the pacemaker through telemetric transmission of programming codes can receive digital and analog (including marker) information from the pacemaker for remote display and utilization, and for program modification in response thereto, if desired. Implementation of the programmer is accomplished partly by circuitry which includes pulse duration measurement circuitry for measuring time duration intervals of incoming RF telemetric signals and partly by a firmware program stored in the programmer.

摘要翻译： 披露了具有遥测能力的起搏器的程序员。 除了能够通过编程代码的遥测传输来编程起搏器之外，程序员还可以接收来自用于远程显示和利用的起搏器的数字和模拟（包括标记）信息，并且如果需要，可以响应于此进行程序修改。 编程器的实现部分地由电路实现，该电路包括用于测量进入的RF遥测信号的持续时间间隔的脉冲宽度测量电路，并且部分地由存储在编程器中的固件程序。

公开(公告)号：US4506969A

公开(公告)日：1985-03-26

申请号：US595995

申请日：1984-04-02

申请人： Richard W. Baker

发明人： Richard W. Baker

IPC分类号： G03D3/06 ,  G03D13/00 ,  G01B11/04

CPC分类号： G03D3/065

摘要： A graphic arts film processor includes a scanner which measures the transmittance of light through the film along a line or a set of parallel lines positioned at a skew angle A with respect to the direction of film travel. A film switch is located at the upstream end of the scanner. The film width is determined based upon the skew angle A, the film transport speed and time intervals between changes in the signals from the scanner and the film switch which correspond to the leading and trailing ends of the film. The film length is determined based upon the transport speed and a time interval between changes in the signal from the film switch corresponding to the leading and trailing ends. Developer replenishment is controlled based upon an integrated transmittance complement measured by the scanner, and fix replenishment is controlled as a function of the film length, the film width, and the integrated transmittance complement.

摘要翻译： 图形艺术胶片处理器包括扫描器，其测量沿着相对于胶片行进方向以歪斜角度A定位的线或一组平行线穿过胶片的光的透射率。 胶片开关位于扫描仪的上游端。 胶片宽度基于偏斜角A，胶片传送速度以及来自扫描仪和胶片开关的信号与胶片的前端和尾端对应的信号的变化之间的时间间隔来确定。 电影长度基于传送速度和对应于前端和后端的胶片开关的信号的变化之间的时间间隔来确定。 基于由扫描仪测量的积分透射补偿来控制显影剂补充，并且根据膜长度，膜宽度和积分透射率补数来控制固定补充。

公开(公告)号：US4445641A

公开(公告)日：1984-05-01

申请号：US338166

申请日：1982-01-08

申请人： Richard W. Baker ,  Yasuo Ninomiya

发明人： Richard W. Baker ,  Yasuo Ninomiya

IPC分类号： A01M13/00 ,  A01N25/18 ,  A01N25/34 ,  A61K9/20 ,  A61K9/70 ,  A61L9/04 ,  A61L9/12 ,  A01M1/00

CPC分类号： A61L9/12 ,  A01M13/00 ,  A01N25/18 ,  A01N25/34 ,  A61K9/2027 ,  A61K9/70 ,  A61L9/042 ,  Y10S43/90

摘要： A dispenser for active ingredients is disclosed which provides zero-order rate of release of essentially all of the active ingredients. The dispenser comprises a rate-controlling membrane and a solid microporous polymeric reservoir having interconnected or continuous pores capable of retaining the active ingredient by capillary forces, the reservoir being such that the active ingredient is essentially insoluble therein.

摘要翻译： 公开了用于活性成分的分配器，其提供基本上所有活性成分的零级释放速率。 分配器包括速率控制膜和具有能够通过毛细管力保持活性成分的互连或连续孔的固体微孔聚合物储存器，储存器使得活性成分基本上不溶于其中。

公开(公告)号：US4308867A

公开(公告)日：1982-01-05

申请号：US23125

申请日：1979-03-23

申请人： Theodore J. Roseman ,  Osmer S. Carpenter ,  Richard W. Baker ,  James W. Ayres

发明人： Theodore J. Roseman ,  Osmer S. Carpenter ,  Richard W. Baker ,  James W. Ayres

IPC分类号： A61K9/48 ,  A61F13/20 ,  A61K9/00 ,  A61K31/557 ,  A61M7/00

CPC分类号： A61F13/28 ,  A61F13/2051 ,  A61F13/2068 ,  A61F13/2074 ,  A61K31/557 ,  A61K9/0036 ,  A61F13/2011 ,  Y10S604/904

摘要： The present specification describes a medicated device adapted for a single and rate-controlled rectal or vaginal administration to a mammal of a systemically active pharmaceutical (SAP). The device accomplishes drug administration at an essentially time-independent rate of dosage. Further, the device advantageously results in the substantial exhaustion of the SAP from the device at the conclusion of the single, acute use. The device comprises three elements:(A) an inert resilient support means contoured for easy vaginal or rectal insertion;(B) a first flexible polymer film layer affixed to the support means and containing the SAP dispersed therethrough, this first polymer film not being rate limiting as to the release of drug from the device; and(C) a second polymer film, laminated onto the first polymer film and providing a release rate therefrom of prostaglandin, which is rate limiting both as to the release of prostaglandin from the device and absorption rate by the rectal or vaginal tissues.

摘要翻译： 本说明书描述了一种适用于单一和速率控制的直肠或阴道给药的药物装置，其用于系统活性药物（SAP）的哺乳动物。 该装置以基本上时间独立的剂量速率实现药物给药。 此外，该装置有利地导致在单次急性使用结束时SAP从装置中显着耗尽。 该装置包括三个元件：（A）易于阴道或直肠插入的惰性弹性支撑装置; （B）第一柔性聚合物膜层，其固定在支撑装置上并含有分散在其中的SAP，该第一聚合物膜不能限制药物从装置中的释放; 和（C）第二聚合物膜，层压在第一聚合物膜上并提供前列腺素的释放速率，前列腺素的释放速率限于前列腺素从装置中的释放和由直肠或阴道组织吸收的速率。

公开(公告)号：US20150129413A1

公开(公告)日：2015-05-14

申请号：US14075578

申请日：2013-11-08

申请人： Yu Huang ,  Richard W. Baker

发明人： Yu Huang ,  Richard W. Baker

IPC分类号： B01D53/22

CPC分类号： B01D53/229 ,  B01D53/226 ,  B01D53/228 ,  B01D2256/24 ,  B01D2257/7022 ,  B01D2257/80 ,  B01D2311/04 ,  B01D2311/06 ,  B01D2311/25 ,  B01D2311/2669

摘要： A gas separation process for treating a gas stream containing vapors of condensable components. The process includes two membrane separation steps, the second step using membranes of lower selectivity than the first step. Advantageously, the first membrane separation step may be carried out outside the pressure-ratio-limited region and the second membrane separation step may be carried out within the pressure-ratio-limited region. The second residue stream is a desired product of the process, and the process is particularly useful for applications where the target concentration of component A in this product is low, such as below 1-2 vol %.

摘要翻译： 一种用于处理含有可冷凝组分蒸汽的气流的气体分离方法。 该方法包括两个膜分离步骤，第二步使用比第一步低的选择性膜。 有利地，第一膜分离步骤可以在压力比限制区域的外部进行，第二膜分离步骤可以在压力比限制区域内进行。 第二残余物流是该方法的所需产物，并且该方法特别适用于该产品中组分A的目标浓度低，例如低于1-2体积％的应用。